New adjuvanted flu vaccine aims to boost protection in older adults
NCT ID NCT05501561
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This phase 2b trial tests several versions of an experimental flu vaccine that includes an adjuvant (MF59) to strengthen the immune response. The vaccine is made from cells, not eggs, and targets four flu strains. Around 1,000 adults aged 50 and older receive a single shot and are followed for about six months to check safety and immune response. The goal is to find the best dose of antigen and adjuvant for this age group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MF59-adjuvanted quadrivalent cell-derived influenza vaccine
What this could lead to
If successful, this vaccine could offer stronger and broader protection against seasonal flu for older adults, who are at higher risk of severe illness.
What could go wrong
This is a mid-stage trial focused on immune response, not yet proven to prevent flu in the real world. Different formulations are being compared, and the best one may still fail in later studies.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AMR Coastal Clinical Research
Knoxville, Tennessee, 37920, United States
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AMR El Dorado
El Dorado, Kansas, 67042, United States
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AMR Lexington
Lexington, Kentucky, 40509, United States
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AMR Tempe
Tempe, Arizona, 85281, United States
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Alliance for Multispecialty Research, LLC, Las Vegas
Las Vegas, Nevada, 89119, United States
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Aventiv Research, Inc. Columbus
Columbus, Ohio, 43213, United States
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CVS pharmacy - Charlottesville
Charlottesville, Virginia, 22902, United States
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CVS pharmacy - Reston
Reston, Virginia, 20190, United States
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CVS pharmacy - Richmond
Richmond, Virginia, 23235, United States
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California Research Center
San Diego, California, 92123, United States
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CenExel RCA
Hollywood, Florida, 33024, United States
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Clinical Research Consulting, LLC
Milford, Connecticut, 06460, United States
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DM Clinical Research
Tomball, Texas, 77375, United States
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Global Health Research Center
Miami Lakes, Florida, 33016, United States
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Global Health Research Center
Tampa, Florida, 33615, United States
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Health Awareness INC
Jupiter, Florida, 33458, United States
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Healthcare Research Network
Hazelwood, Missouri, 63042, United States
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Innovative Research of West Florida, Inc.
Clearwater, Florida, 33756, United States
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JBR Clinical Research
Salt Lake City, Utah, 84107, United States
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Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112, United States
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M3 Wake Research, Inc.
Raleigh, North Carolina, 27612, United States
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Marvel Clinical Research
Huntington Beach, California, 92647, United States
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MedPharmics LLC
Biloxi, Mississippi, 39531, United States
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Medpharmics, LLC
Metairie, Louisiana, 70006, United States
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Meridian Clinical Research
Baton Rouge, Louisiana, 70808, United States
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Meridian Clinical Research
Bellevue, Nebraska, 68005, United States
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Meridian Clinical Research
Grand Island, Nebraska, 68803, United States
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Meridian Clinical Research (Binghamton, NY)
Binghamton, New York, 13901, United States
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Meridian Clinical Research - Dakota Dunes
Dakota Dunes, South Dakota, 57049, United States
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Meridian Clinical Research - Savannah
Savannah, Georgia, 31406, United States
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Meridian Clinical Research, LLC
Lincoln, Nebraska, 68510, United States
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Meridian Clinical Research, LLC
Endwell, New York, 13760, United States
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Meridian Clinical Research, LLC
Cincinnati, Ohio, 45219, United States
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Meridian Clinical Research, LLC
Cincinnati, Ohio, 45246, United States
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Platinum Research Network, LLC
Savannah, Georgia, 31405, United States
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Precision Clinical Research
Sunrise, Florida, 33351, United States
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Rockville Internal Medicine Group
Rockville, Maryland, 20854, United States
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Sundance Clinical Research, LLC
St Louis, Missouri, 63141, United States
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The Center for Pharmaceutical Research
Kansas City, Missouri, 64114, United States
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The Lynn Institute of The Rockies
Colorado Springs, Colorado, 80920, United States
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Velocity Clinical Research - Greenville
Greenville, South Carolina, 29615, United States
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Velocity Clinical Research - Medford
Medford, Oregon, 97504, United States
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Velocity Clinical Research - New Smyrna Beach
Edgewater, Florida, 32132, United States
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Velocity Clinical Research - Syracuse
Syracuse, New York, 13057, United States
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Velocity Clinical Research - West Jordan
West Jordan, Utah, 84088, United States
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Velocity Clinical Research, Gaffney
Gaffney, South Carolina, 29340, United States
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Velocity Clinical Research, Spartanburg
Spartanburg, South Carolina, 29303, United States