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COVID drug showdown: 3,800 patients test which pill kills virus fastest

NCT ID NCT05041907

Recruiting now Disease control Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing several antiviral drugs—including Paxlovid, molnupiravir, and older drugs like hydroxychloroquine—in 3,800 adults with mild COVID-19. Participants are randomly assigned to receive one of the treatments or no antiviral drug, and researchers measure how quickly the virus clears from their throat and nose over five days. The goal is to identify which drugs speed recovery and reduce viral load, helping guide future treatment choices.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Various antiviral drugs (nirmatrelvir/ritonavir, molnupiravir, nitazoxanide, hydroxychloroquine, fluoxetine, monoclonal antibodies)
What this could lead to
If successful, this trial could identify which existing drugs work best to clear the virus faster in early COVID-19, helping doctors choose the most effective treatment.
What could go wrong
This is a mid-stage trial testing many drugs at once, so results may not confirm which is truly best. Some drugs (like hydroxychloroquine) have already shown mixed results in other studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Bangplee Hospital

    TERMINATED

    Mueang Samut Prakan, 10540, Thailand

  • Faculty of Tropical Medicine, Mahidol University

    RECRUITING

    Bangkok, 10400, Thailand

    Contact Email: •••••@•••••

  • Laos-Oxford-Mahosot Wellcome Trust Research Unit

    RECRUITING

    Vientiane, 01000, Laos

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sukraraj Tropical & Infectious Disease Hospital

    RECRUITING

    Kathmandu, Nepal

    Contact Email: •••••@•••••

  • The Aga Khan University Hospital

    TERMINATED

    Karachi, Pakistan

  • Universidade Federal de Minas Gerais

    RECRUITING

    Minas Gerais, Brazil

    Contact Email: •••••@•••••

  • Vajira hospital

    TERMINATED

    Bangkok, 10300, Thailand

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