University Of Oxford

This study is testing a booster dose of the R21 malaria vaccine in school-aged children in Burkina Faso. It will compare two different strengths of the booster shot to see which is safer and produces a better immune response. The children in the study have already received a full…

This early-stage study is testing the safety and immune response of a new malaria vaccine in healthy adults and young children in Burkina Faso. Researchers are giving different combinations of vaccine components to small groups to see which is safest and most promising. The goal …

This University of Oxford trial aims to directly compare how well seven different antiviral drugs work against the flu. It will enroll 3,000 adults who have just started showing flu symptoms to see which medication clears the virus from their system the fastest. The study will te…

This Oxford University study is testing whether a combination of HIV vaccines and long-acting antibody infusions can help people with HIV control the virus without needing daily medication. The trial will involve 48 participants to see if this approach can train the immune system…

This study aims to find the best oral antibiotic treatment for scrub typhus, a bacterial infection spread by mites. Researchers are comparing three different regimens—two using doxycycline for different lengths of time and one using azithromycin—in 177 hospitalized patients. The …

This study is testing whether a new triple-drug combination treatment works as well as current standard malaria treatments. Researchers will enroll 1,680 patients with uncomplicated malaria in Africa and Asia to compare the new three-drug therapy against two existing two-drug com…

This trial is testing several different antiviral drugs to see which ones work best at clearing the COVID-19 virus from people's bodies. It will enroll 3,800 healthy adults who have just developed mild COVID-19 symptoms. The study compares how quickly different treatments reduce …

This study is testing a new portable device called VITA that aims to detect anemia and iron deficiency in pregnant women without needing a blood draw. Researchers will use the device to scan the ear's blood vessels and compare the results to standard blood tests from 300 particip…

This study is testing if a faster, 20-minute MRI scan without dye is better than the standard ultrasound for finding liver cancer early in people with cirrhosis who are at high risk. Researchers will enroll 300 participants to receive both scans every six months for 30 months to …

This study aims to develop a better, faster way to diagnose lung cancer using artificial intelligence (AI) to analyze blood samples. It will enroll 5,000 people who have a lung nodule found on a screening scan. The goal is to create computer tools that help doctors spot cancer ea…

This study aims to test how well a new rapid diagnostic tool works for detecting scrub typhus, a bacterial infection spread by mites. Researchers in Thailand will compare the new test against existing standard tests in 100 patients with fever and other symptoms. The goal is to se…

This large study aims to prevent malaria by testing different community-wide strategies in African villages. Researchers will compare giving everyone a malaria vaccine, giving everyone preventive drugs, doing both, or doing nothing (current standard). They will follow 10,000 peop…

This study is testing whether a free WhatsApp chatbot can help Palestinian parents living in a refugee camp in Jordan. The chatbot delivers daily parenting tips and mental health support over 9 days. Researchers want to see if using the chatbot improves parents' mental well-being…

This study is testing whether a 10-week online sleep therapy program can help adults with fibromyalgia who also have trouble sleeping. Researchers want to see if improving sleep can lead to better quality of life, less pain, and more willingness to move. Participants will either …

This Oxford University study is testing whether a surgically implanted 'brain pacemaker' (deep brain stimulation) can safely reduce severe, long-lasting pain that sometimes follows a stroke. The trial will enroll 30 adults who have had this debilitating pain for at least two year…

This Oxford study is testing whether a digital sleep improvement program can help stroke survivors sleep better. Researchers want to see if better sleep helps the brain consolidate motor skills learned during rehabilitation. About 100 participants will try the online sleep therap…

This study aims to predict which patients with severe endometriosis will get lasting pain relief from surgery. Researchers will use brain scans and other tests before surgery to see if they can forecast the 12-month pain outcome. The goal is to help patients and doctors make bett…

This study aims to safely create a 'human challenge' model for a type of malaria called Plasmodium vivax. Six healthy Thai adults will be deliberately infected via mosquito bites to see if the infection process works reliably and is safe. The main goals are to collect infected bl…

This study aims to find the minimum number of bites from malaria-infected mosquitoes needed to reliably cause infection in healthy Thai adults. Researchers will deliberately expose small groups of volunteers to 1, 2, or 3 mosquito bites in a controlled hospital setting to measure…

This University of Oxford study aims to understand how the antidepressant fluoxetine (Prozac) affects how healthy young people process anger. 80 participants aged 18-24 will take either a 20mg fluoxetine pill or a placebo daily for one week and complete tasks designed to measure …

This Oxford University study aims to understand how tiny particles released by the placenta contribute to serious pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect samples from 360 women, including those with healthy pregnancies and tho…

This University of Oxford study aims to understand how a brain chemical called orexin affects emotions and learning. Healthy volunteers will take a single dose of a sleep medication (daridorexant) or a placebo and complete computer tasks measuring emotional responses and learning…

This study aims to find a safe and reliable way to give healthy volunteers a controlled, mild malaria infection. Researchers will inject a small, frozen sample of malaria-infected blood into up to 48 healthy Thai adults and monitor them closely in a hospital. The goal is to creat…

This large observational study aims to identify what causes fevers and how they affect patients in rural areas of Laos, Myanmar, Thailand, and Bangladesh. Researchers will enroll 7,200 people of all ages who visit health facilities with a recent fever. By collecting samples and t…