University Of Oxford

This study tests a new malaria vaccine in healthy adults (18-35 years) and children (5-17 months) in Burkina Faso. The vaccine combines three parts of the malaria parasite to try to give stronger protection. The main goal is to check if it is safe and how well the immune system r…

This study tests a booster dose of the R21/Matrix-M malaria vaccine in 30-40 school children in Burkina Faso who already received four doses years earlier. Researchers want to see if a booster is safe and how well it boosts immunity. Two different booster doses are compared, and …

This large study tests various treatments for people hospitalized with pneumonia, including from COVID-19 and flu. The main goal is to see which treatments reduce the risk of death. Over 70,000 participants are involved, and the study compares multiple drugs to standard care.

This study tests whether a new triple-combination malaria pill (ALAQ) works as well as current two-drug treatments for uncomplicated malaria. About 1,680 people with malaria will receive either the new triple drug or a standard treatment and be monitored for 42 days. The goal is …

This study looks at whether a finger-prick blood test done at home can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard test requires a vein drip and multiple blood draws over hours, which…

This study tests whether a fast, no-dye MRI scan can find liver cancer earlier than the standard ultrasound in 300 people with cirrhosis who are at high risk. Participants will get both scans every 6 months for 2.5 years. The goal is to see if the MRI catches cancers that ultraso…

This study is testing a portable device called VITA that uses a special camera to take pictures of blood vessels in the ear to check for anemia (low iron) in pregnant women. The goal is to see if this quick, painless method works as well as standard lab blood tests. The study wil…

This large study in villages tests whether giving malaria vaccines and drugs together, either alone or combined, can reduce malaria cases better than current care. About 10,000 people aged 6 months and older will take part. Researchers will track infections over two years to see …

This study looks at whether a digital sleep therapy program (Sleepio) can help adults with fibromyalgia who also have trouble sleeping. About 142 participants will use the program at home for 10 weeks or receive standard sleep advice. Researchers will track changes in quality of …

This study tests whether a digital program called Sleepio, which uses cognitive behavioral therapy for insomnia, can improve sleep in stroke survivors. Researchers will also see if better sleep helps with learning motor skills during rehabilitation. About 100 adults who have had …

This study is watching and recording what happens when people in rural parts of Laos, Myanmar, Thailand, and Bangladesh get a fever. Researchers will test 7,200 patients to find out which germs are causing the illness and how well people recover. The goal is to learn more, not to…

This study looks at how tiny particles released by the placenta, called extracellular vesicles, affect pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect samples from 360 pregnant and non-pregnant women to understand these particles' rol…

This study uses MRI scans to see how iron moves to different organs like the heart, liver, and kidneys after an intravenous iron infusion. Researchers will follow 12 adults with iron deficiency for hours, days, and weeks after treatment. The goal is to learn more about iron stora…

This study is for 80 adults with blood cancers like MDS or AML who are starting treatment. Researchers will give them a smartwatch to track activity and ask them to fill out surveys about how they feel. The goal is to see how low blood counts affect quality of life and find bette…

This study aims to see if brain imaging can predict which women with severe endometriosis will have less pain after surgery. Researchers will scan the brains of 100 women before their operation and check their pain levels a year later. The goal is to better understand who benefit…

This study tests different COVID-19 treatments in people with mild symptoms to see how quickly they clear the virus from the body. About 3,800 healthy adults aged 18-60 with early COVID-19 will take part. Researchers compare antiviral drugs and antibodies against no treatment to …

This study aims to find the smallest number of infected mosquito bites needed to reliably give a person malaria. Healthy Thai adults will be bitten by malaria-carrying mosquitoes under controlled conditions. The results will help researchers design safer and more accurate vaccine…

This study looks at why women who had high blood pressure during pregnancy are more likely to develop high blood pressure and heart disease later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to bett…

This study at the University of Oxford looks at how a drug called pimavanserin, which blocks a specific serotonin receptor in the brain, affects memory, emotional processing, and decision-making. Researchers will give the drug or a placebo to 80 healthy adults aged 18-45 and comp…

This study follows up to 90 babies (60 with SMA and 30 healthy) from birth to age 4 to see how their muscles develop. Using special wearable devices worn at home, researchers aim to spot when movement first differs from normal. This will help doctors decide the best time to give …

This study aims to see if it is safe and possible to give healthy Thai adults a controlled malaria infection using frozen infected blood cells. Up to 48 volunteers will receive one of four doses and be closely monitored in the hospital. The goal is to find the best dose for futur…

This study looks at how the immune systems of people being treated for tuberculosis respond to COVID-19 vaccines compared to healthy people. About 108 adults (54 with TB and 54 healthy) will receive one or two doses of a standard COVID-19 vaccine. Researchers will measure antibod…

This study is testing whether 'Hope Groups' — a support program that combines mental health help, parenting tips, and violence prevention — can improve the well-being of Palestinian caregivers displaced by war. About 490 parents or caregivers living in refugee camps will take par…

This study looks at how the antidepressant fluoxetine changes the way healthy young people (ages 18-24) process anger. Participants take either fluoxetine or a placebo daily for 7 days and complete tasks involving angry words, faces, and frustrating situations. Researchers measur…

This study looks at a molecule called BH4, which helps blood vessels stay healthy, in pregnant women with high blood pressure. Researchers want to see if BH4 levels are linked to how the heart and blood vessels work, and if a nutritional supplement (5-MTHF) can improve those leve…