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Malaria vaccine booster trial aims to keep school kids protected

NCT ID NCT07074665

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a booster shot of the R21/Matrix-M malaria vaccine in 40 school-age children in Burkina Faso who already received four doses years earlier. Half get the standard child dose, half get a higher adult dose. Researchers will check for side effects and measure antibody levels over one year to see if a booster is safe and boosts immunity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
R21/Matrix-M malaria vaccine
What this could lead to
If successful, this could show that a booster dose of the R21/Matrix-M vaccine is safe and effective for school-age children, helping to maintain protection against malaria as they grow older.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply to all children. The main focus is safety and immune response, not whether it prevents malaria. Side effects like injection site pain or fever are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Plasmodium falciparum malaria malaria prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALARIA (PLASMODIUM FALCIPARUM)

Contacts and locations

Locations

  • Unité de Recherche Clinique de Nanoro (URCN)

    RECRUITING

    Nanoro, PO Box 11 BP 218 Ouaga CMS 11, Burkina Faso

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