Can a single shot of a genetically weakened malaria parasite train the body to fight off the real thing?
NCT ID NCT07730177
First seen Jul 28, 2026 · Last updated Jul 31, 2026 · Updated 2 times
Summary
This trial tests a new malaria vaccine, PfSPZ-LARC2, made from live but genetically weakened malaria parasites that stop developing in the liver and never reach the bloodstream. The goal is to see if a single dose can safely and effectively protect healthy adults in Burkina Faso from malaria when they are later exposed to the parasite under controlled conditions. The vaccine is designed to trigger a strong immune response without causing actual malaria illness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a genetically weakened malaria vaccine called PfSPZ-LARC2, given as a single injection
- What this could lead to
- If successful, this could pave the way for a single-dose vaccine that provides strong, lasting protection against malaria.
- What could go wrong
- This is an early phase 1 trial with only 45 participants, so safety and efficacy are not yet established. The vaccine is genetically modified, and long-term effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Groupe de Recherche Action en Santé (GRAS)/Unité de Recherche Clinique de Sabou
Ouagadougou, 06, Burkina Faso
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Other studies related to the condition(s) this trial covers.
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