Could a Liver-Stage malaria vaccine shield mothers and babies?
NCT ID NCT07675785
First seen Jun 30, 2026 · Last updated Jul 24, 2026 · Updated 5 times
Summary
This phase 2 trial tests a new malaria vaccine (PfSPZ-LARC2) designed to stop the malaria parasite in the liver before it can cause illness. The study involves 300 healthy women of childbearing age in Mali who plan to become pregnant. Participants receive three doses of the vaccine or a placebo, and researchers monitor safety, immune response, and protection against malaria over two years, including during pregnancy and after delivery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PfSPZ-LARC2 Vaccine (live, weakened malaria parasites)
- What this could lead to
- If successful, this vaccine could protect women and their future babies from malaria, potentially reducing severe illness and death in high-risk areas.
- What could go wrong
- This is a phase 2 trial with 300 participants, so results may not apply broadly. The vaccine uses live parasites, which carries a risk of causing malaria-like symptoms or unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Sciences, Techniques and Technology, Bamako (USTTB)
RECRUITINGBamako, Mali
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Other studies related to the condition(s) this trial covers.
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