Can a single dose of tafenoquine finally cure vivax malaria in southeast asia?

NCT ID NCT04704999

Recruiting now ⭐️ CURE ⭐️ Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests different doses of tafenoquine, a single-dose drug, to see if it can effectively cure Plasmodium vivax malaria by targeting dormant liver stages. The study involves 820 people in Southeast Asia with confirmed vivax malaria. Researchers aim to find a dose that prevents relapse better than current treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tafenoquine
What this could lead to: If successful, this could establish a single-dose cure for vivax malaria in Southeast Asia, replacing longer treatments and reducing relapse rates.
What could go wrong: The trial is testing dose optimization, and previous data showed the standard dose had low efficacy in this region. Higher doses may increase side effects like hemolysis.

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Conditions

The condition(s) this trial relates to.

Plasmodium vivax malaria Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLASMODIUM VIVAX MALARIA

Contacts and locations

Locations

Lao Oxford Mahosot Hospital Wellcome Trust Research Unit (LOMWRU)
RECRUITING

Vientiane, Laos
Mahidol Oxford Tropical Medicine Research Unit (MORU), Cambodia
RECRUITING

Siem Reap, Cambodia
Mahidol Vivax Research Unit (MVRU)
RECRUITING

Bangkok, Thailand
Oxford University Clinical Research Unit (OUCRU)
NOT_YET_RECRUITING

Bình Phước, Vietnam
Oxford University Clinical Research Unit (OUCRU-Indonesia)
NOT_YET_RECRUITING

Jayapura, Indonesia
Shoklo Malaria Research Unit (SMRU)
RECRUITING

Bangkok, Thailand

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