University Of Oxford

This study is testing a new experimental rabies vaccine (called ChAdOx2 RabG) to see if it is safe and how well it triggers an immune response. It involves 174 healthy adults and young children in Tanzania, where rabies is common. Researchers are comparing the new vaccine, given …

This study is testing a malaria vaccine called R21/Matrix-M1 in healthy women in Mali who are of childbearing age and plan to become pregnant. The goal is to see if the vaccine is safe, how well the immune system responds to it, and if it protects against malaria infection. Resea…

This large, final-stage trial is testing whether a new vaccine called R21/Matrix-M can safely protect young children in Africa from getting sick with malaria. It involves 4,800 children aged 5-36 months across several African countries. The study compares the malaria vaccine agai…

This study is testing the safety of a new tuberculosis vaccine called ID93/GLA-SE. Researchers are using a controlled infection model where 48 healthy volunteers are exposed to a weakened, harmless form of TB bacteria through inhalation. The goal is to see if the new vaccine is s…

This study is testing two new malaria vaccine combinations in young children in Burkina Faso, where malaria is common. It will involve 360 healthy children aged 5 to 36 months to see if the vaccines are safe and how well they prevent malaria over six months. The goal is to find a…

This study is testing a new vaccine, called ChAdOx1 RVF, to protect adults in Kenya from Rift Valley Fever, a serious mosquito-borne disease. Researchers will give the vaccine to 240 healthy adults to see if it safely triggers a strong and lasting immune response. They will compa…

This early-stage study is testing whether giving multiple increasing doses of the R21 malaria vaccine is safe and triggers a good immune response. It involves 36 healthy UK adults who have never had malaria. Researchers will compare this new multi-dose schedule against the standa…

This early-stage study is testing the safety and immune response of two new malaria vaccine candidates. One vaccine targets the malaria parasite in the liver, while the other targets it in the blood. Researchers are giving the vaccines separately and together to 107 healthy adult…

This large study is testing whether a new cholesterol-lowering injection called inclisiran can safely reduce the risk of future heart attacks, strokes, and related heart problems in people who already have heart disease. Over 16,000 participants received either the injection or a…

This study is testing if a drug called aldesleukin can help children and young adults recently diagnosed with type 1 diabetes keep producing their own insulin. It aims to calm the immune system's mistaken attack on insulin-making cells. The trial involves 41 participants who will…

This study aimed to test if new, higher-frequency electrical stimulation settings could improve bladder control for people with spinal cord injury. It planned to test 5-10 people who already had an implanted bladder stimulator, comparing new settings to their usual therapy. The g…

This study is testing two new malaria vaccines in healthy children and adults in Burkina Faso. The main goal is to check if the vaccines are safe and to see if they can help stop the spread of malaria by blocking the parasite from passing between people via mosquitoes. Researcher…

This study aims to see if an antibiotic works as well when given as a rectal capsule or tablet compared to the standard intravenous (IV) injection. It involves 37 healthy Thai adults who will try all three methods in a random order. The main goal is to measure how much of the dru…

This study aims to see if new blood tests can accurately diagnose different types of dementia in real-world medical settings. Researchers will follow 3,165 people aged 45+ with memory concerns at UK memory clinics over three years. Participants will give blood samples and complet…

This study aims to see if giving a TB vaccine booster through an inhaled mist is more effective than the standard skin injection. Researchers will compare immune responses in 36 adults who received the BCG vaccine as children, including a group with type 2 diabetes. The goal is t…

Researchers at the University of Oxford are running a study where they deliberately give a small dose of the Omicron BA.5 COVID-19 virus to healthy, vaccinated volunteers. The goal is to find the right dose that causes a mild, controlled infection in most people, creating a safe …

This study aims to understand if a specific immune response marker found in infected lung fluid is linked to how severe a chest infection gets and a patient's risk of dying within a year. Researchers observed 326 adult patients with severe pleural infections from around the world…

This large UK study is testing whether inviting women for breast cancer screening at younger (47-49) and older (71-79) ages saves more lives than the current program for ages 50-70. About 4 million women across England are participating, with half being offered the extra screenin…

This study aimed to learn if deep brain stimulation, a treatment for severe tremor, also affects simple breathing functions like how long someone can hold their breath. It planned to test this in patients already scheduled to receive the treatment for essential or dystonic tremor…