University Of Oxford

This early-stage study tests whether giving the R21/Matrix-M malaria vaccine in a new, escalating-dose schedule is safe and creates a strong immune response. It involves 36 healthy adults in the UK who have never had malaria. The goal is to find a better way to protect people fro…

This study tests two experimental malaria vaccines in 360 children aged 5 to 36 months in Burkina Faso, a country where malaria is common. The vaccines aim to prevent malaria caused by the Plasmodium falciparum parasite. Researchers will check how safe the vaccines are, how well …

This study tests two experimental vaccines designed to stop the malaria parasite from spreading from person to person. The vaccines target the parasite's development inside mosquitoes, so vaccinated people who get bitten are less likely to pass the infection on. The trial involve…

This study tests the R21/Matrix-M1 malaria vaccine in 330 healthy women aged 18–35 in Mali who may become pregnant. Participants receive two or three doses of the vaccine or a placebo, and are followed for two years to check safety, immune response, and protection against malaria…

This large-scale study tests the R21/Matrix-M vaccine to prevent malaria in 4,800 children aged 5-36 months living in Africa. The vaccine aims to protect against the most dangerous form of malaria. Researchers will measure how well it works and check for side effects over one yea…

This Phase 2 trial tests a new vaccine called ChAdOx1 RVF against Rift Valley fever in 240 healthy adults in Kenya. Participants receive either one or two doses of the vaccine or a rabies vaccine as a control. Researchers will check if the vaccine triggers a strong immune respons…

This study tests a new rabies vaccine called ChAdOx2 RabG, given as a single shot. It involves 174 healthy adults (18-45 years) and young children (2-6 years) in a country where rabies is common. The goal is to see if the vaccine is safe and triggers a strong immune response, com…

This study is testing whether a daily semaglutide tablet can safely reduce the risk of heart attacks, strokes, and related deaths in over 21,000 adults with type 2 diabetes who have never had a heart attack or stroke. Participants take either semaglutide or a placebo pill for sev…

This large phase 3 study tests a new cholesterol-lowering injection called inclisiran in over 16,000 people who have already had a heart attack, stroke, or artery surgery. The goal is to see if it safely reduces the risk of future heart attacks, strokes, or the need for emergency…

This study tests three antibiotic regimens for scrub typhus, a bacterial infection spread by mites. Researchers compare 7 days of doxycycline, 3 days of doxycycline, and 3 days of azithromycin in 177 hospitalized patients aged 15 and older. The goal is to see which treatment clea…

This phase 2 trial is testing whether aldesleukin, a drug that helps regulate the immune system, can preserve insulin production in children and young adults (ages 6-18) recently diagnosed with type 1 diabetes. Participants receive either aldesleukin or a placebo for 6 months, an…

This study collects blood samples from 872 people with lung nodules to develop artificial intelligence (AI) tools that can help diagnose lung cancer earlier and more accurately. The goal is to combine blood tests with CT scans to improve detection and reduce the need for invasive…

This large UK study (EVAREST) aims to improve how doctors interpret stress echocardiograms for diagnosing coronary artery disease. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients to find new biomarkers that make diagnosis more a…

Over two million people in the UK have a chronic condition like diabetes or heart disease without knowing it. This study will use information from 4.5 million hospital patients to build a digital platform that spots those at risk. The goal is to help doctors diagnose these condit…

This study follows 100 ICU patients who developed new atrial fibrillation (AF) during their stay. Using a chest-worn heart monitor, researchers track whether AF returns after leaving the ICU and up to 3 months after hospital discharge. The goal is to understand who might need lon…

This study looks at whether giving the BCG vaccine as a mist breathed into the lungs works better than the usual injection under the skin. It includes 36 healthy adults who have already had BCG, some with type 2 diabetes and some without. Researchers will measure immune responses…

This study intentionally exposes healthy adults aged 18-40 who have had a COVID-19 vaccine or prior infection to the Omicron BA.5 virus via nasal drops. The goal is to find the safest dose that causes a mild, controlled infection in 50-75% of participants, while monitoring side e…

This study follows 45 people with nemaline myopathy in the UK to learn how the disease naturally progresses. Researchers collect medical exams, quality-of-life surveys, and physical assessments over time. The goal is to identify the best ways to measure the disease in future clin…

This early-stage study tests whether a common antibiotic (ceftriaxone) can be given as a rectal suppository instead of an injection. 37 healthy Thai adults will try both forms to compare how well the drug is absorbed and any side effects. The goal is to find a needle-free option …

This nationwide trial is looking at whether inviting women aged 47-49 and 71-73 for breast screening helps reduce deaths from breast cancer. Over 4 million women across England are taking part. The study compares breast cancer deaths and treatments between those invited and those…

This study tests the safety of a new tuberculosis vaccine called ID93/GLA-SE in 48 healthy adults, some of whom have had the standard BCG vaccine before. Researchers will also use an experimental method where a weakened form of TB bacteria is given as an aerosol to see how the im…

This study is testing whether simple blood tests can accurately diagnose dementia in everyday clinic settings. Over 3,000 people aged 45 and older with memory problems will give blood samples and answer questionnaires. Researchers will check how reliable and acceptable these bloo…

This study was designed to find out if deep brain stimulation (DBS) in the thalamus, used to treat essential or dystonic tremor, also changes breathing. Researchers planned to measure breath-holding and peak airflow in a small group of patients before and after DBS surgery. Howev…

This study aimed to test whether high-frequency electrical stimulation could improve bladder control in people with spinal cord injury who already have a special device implanted. Researchers planned to compare high-frequency versus low-frequency stimulation in 5 to 10 participan…

This study examines whether tiny webs released by immune cells, called neutrophil extracellular traps (NETs), are linked to how severe a pleural infection is and the risk of dying within a year. Researchers analyzed fluid from the chest cavity of 326 patients across multiple coun…