University Of Oxford

This study tests two experimental vaccines designed to stop the spread of malaria from person to person. They are given to healthy volunteers aged 5 to 45 in Burkina Faso, where malaria is common. The goal is to check if the vaccines are safe and trigger a strong immune response.

This early-stage study tests whether a new way of giving the R21/Matrix-M™ malaria vaccine is safe and creates a strong immune response. About 36 healthy adults in the UK who have never had malaria will receive either the standard vaccine schedule or an experimental one with incr…

This study tests a new rabies vaccine called ChAdOx2 RabG in healthy adults (18-45 years) and young children (2-6 years) living in a country where rabies is common. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants receive either the ne…

This study tests three different antibiotic treatments for scrub typhus, a bacterial infection spread by mites. It involves 177 hospitalized adults in areas where the bacteria may be resistant to common drugs. The goal is to see which treatment clears the fever fastest and preven…

This study tests a drug called aldesleukin to see if it can help children and young adults (ages 6-18) recently diagnosed with type 1 diabetes keep making their own insulin. Participants are split into two groups: one gets the drug, the other gets a placebo. The goal is to measur…

This large study tests whether a new injection called inclisiran can safely lower the risk of heart attacks and strokes in people who have already had one. Over 16,000 participants receive either the injection or a placebo. The goal is to see if this treatment reduces major heart…

This study is looking for better ways to diagnose coronary artery disease using stress echocardiograms. Researchers will collect blood samples and analyze heart images from up to 23,000 patients in the UK to find new markers that make the test more accurate. The goal is to improv…

This study tests whether a common antibiotic (ceftriaxone) given as a rectal suppository works as well as the standard IV injection. 37 healthy Thai adults will try both forms and have their blood levels measured. The goal is to find a needle-free option for patients who cannot g…

This study follows 45 people with nemaline myopathy in the UK to learn how the disease naturally progresses. Researchers will collect medical exams, quality-of-life surveys, and physical and breathing tests over time. The goal is to find the best ways to measure the disease in fu…

This study tests whether giving the BCG vaccine as an inhaled mist works better than the usual injection for boosting immunity against tuberculosis. It includes 36 healthy adults who have already had the BCG vaccine, some with type 2 diabetes and some without. Researchers will me…

This study is testing whether blood tests can accurately diagnose dementia in everyday clinics. Researchers will collect blood samples and questionnaires from 3,165 adults aged 45 and older with memory problems. The goal is to see if these tests are reliable, acceptable to patien…

This study looks at whether offering breast cancer screening to women aged 47-49 and 71-73 can reduce deaths from breast cancer. Over 4 million women in England are taking part. Researchers will compare breast cancer deaths and treatments between women who get the extended screen…

This study was designed to see if deep brain stimulation (DBS) of a brain area called VIM changes how people with essential or dystonic tremor breathe. Researchers planned to measure breath-holding time and peak airflow in a small group of patients before and after DBS surgery. T…

This study tests the safety of a new tuberculosis (TB) vaccine called ID93/GLA-SE. Forty-eight healthy adults, some previously vaccinated with BCG and some not, will receive the new vaccine and then be exposed to a harmless form of TB bacteria through an aerosol mist. Researchers…