Can smarter antibiotic use curb Drug-Resistant infections?

NCT ID NCT07082465

Ongoing Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study looks back at medical records from four hospitals in Thailand to understand what happens when doctors reduce antibiotic treatment (de-escalation) in patients who received short-course IV antibiotics. It compares outcomes like new resistant infections and death between those who had de-escalation and those who didn't. The study also tests automated outbreak detection and develops new stewardship indicators for low- and middle-income countries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: This could help hospitals in low- and middle-income countries improve antibiotic use and reduce drug-resistant infections.
What could go wrong: Because it's observational, it can't prove cause and effect. Results may not apply to other settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease bacterial infectious disease with sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACTEREMIA BACTERIAL DRUG RESISTANCE

Contacts and locations

Locations

Chaoprayayommarat Hospital

Suphan Buri, Thailand
Chiangrai Prachanukroh Hospital

Chiang Rai, Chiangrai, Thailand
Phrachomklao Hospital

Phetchaburi, Thailand
Sunpasitthiprasong Hospital

Ubon Ratchathani, Thailand

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