University Of Oxford

This study tested the safety and immune response of a new malaria vaccine called R21/Matrix-M in nearly 600 young children in Mali. Researchers compared different ways of preparing and scheduling the vaccine, and checked if it was safe to give alongside other standard childhood s…

This study tested the safety and immune response of a new malaria vaccine in young African children, most of whom were living with HIV. Researchers gave 122 children aged 5-36 months a series of three vaccine shots plus a booster. The main goal was to see if the vaccine was safe …

This large study tested the Oxford/AstraZeneca COVID-19 vaccine to see if it was safe and effective at preventing illness. Over 10,000 healthy adults in the UK received the vaccine or a control shot and were followed for a year. The main goals were to measure how well it prevente…

This early-stage study tested a new COVID-19 vaccine called ChAdOx1 nCoV-19 to see if it was safe and if it could protect people from getting sick. It involved 1077 healthy adult volunteers in the UK, aged 18 to 55, who received the vaccine as a shot in the arm. The main goals we…

This large study tested whether adding a third anti-malaria drug to the standard two-drug combination is as effective or better at treating uncomplicated malaria in children. Over 2,500 children across Africa participated, receiving either the standard treatment or the new triple…

This early-stage trial tested whether adding an oral drug called atovaquone to standard chemoradiation is safe for patients with locally advanced non-small cell lung cancer. The study involved 21 patients to find the highest safe dose of atovaquone. Researchers also checked if th…

This study tested if sildenafil (the active ingredient in Viagra) could help people who have had a minor stroke caused by small vessel disease. Researchers gave 75 participants sildenafil, a placebo, and another blood vessel drug in random order for three weeks each. They used ul…

This small Oxford study tested a new 'adaptive' deep brain stimulation device in 3 patients with Multiple System Atrophy (MSA), a severe neurodegenerative disease. The device automatically adjusts stimulation based on whether patients are lying down or standing up, aiming to bett…

This study tested whether small, wireless sensors worn by hospital patients could help nurses detect health declines faster than standard checks. 240 surgical patients at Oxford University Hospitals wore devices that continuously tracked vital signs like heart rate and oxygen lev…

This study tested whether a 12-week smartphone app program, which provides coaching and recipes for a low-carbohydrate diet, could help people recently diagnosed with type 2 diabetes. 115 participants were randomly assigned to either use the app or continue with their usual docto…

This study tested whether oral ivermectin is safe and effective for treating scabies in young children weighing 5-15kg. Researchers compared the pill to the standard permethrin cream treatment in 240 children. The goal was to gather safety data to potentially expand treatment opt…

This small study tested a special, child-friendly tablet version of the drug ivermectin to treat scabies in very young children. It aimed to find a safe and effective dose for infants and toddlers weighing between 11 and 33 pounds. The main goals were to check the drug's safety, …

This study compared three treatment approaches for people newly diagnosed with moderate to severe psoriatic arthritis. Researchers tested whether starting with stronger combination medications or biologic drugs works better than the standard approach of starting with one medicati…

This study tested a new screening program for babies to detect spinal muscular atrophy (SMA), a severe genetic muscle disease, as early as possible. Over 33,500 newborns in the UK were screened using a tiny extra blood spot from their routine newborn test. The goal was to see if …

This study tested a community health program called 'Saving Babies' Lives' in a remote province of Cambodia. The program trained local health workers and held village meetings to identify and solve problems in newborn care. The goal was to create a practical model that could be s…

This study tested whether a structured weight loss and behavioral support program could reduce symptoms related to atrial fibrillation (AF) in older, overweight patients. 119 participants aged 60-85 with AF were randomly assigned to either the weight loss program or usual care fo…

This study tested whether 'Hope Groups'—peer-led support sessions for Ukrainian caregivers—could improve mental health and parenting during wartime. Over 500 caregivers were randomly assigned to either join the 12-session groups immediately or wait for later support. Researchers …

This study tested whether an online sleep therapy program called Sleepio could help people who have had a stroke sleep better. Researchers compared the digital program against basic sleep advice given in a leaflet. The goal was to see if this convenient online approach could impr…

This study aimed to understand how the human immune system responds to mosquito bites. Healthy volunteers were exposed to controlled bites from specific mosquito species that can carry malaria or dengue. Researchers measured antibody levels in the volunteers' blood over time to i…

This study investigated whether taking iron supplements helps pregnant women build a stronger immune response to important vaccines. Researchers compared the vaccine responses of 171 pregnant women who were anemic and received treatment-dose iron supplements to women who were not…

This study aimed to understand what causes people to die in remote villages across five Asian countries where official death records are often missing. Researchers interviewed over 3,400 family members of people who had recently died to learn about their symptoms and medical hist…

This study aimed to better understand a common ICU procedure used to re-inflate collapsed lungs in patients on breathing machines. Researchers observed 48 critically ill adults to learn which measurements can predict if this 'recruitment maneuver' will successfully open the lung.…

This study aimed to understand severe infections (sepsis) that people get outside the hospital in Thailand. Researchers observed over 1,000 adult patients to test a new medical definition for sepsis and to find out what germs cause it and what factors lead to better or worse outc…

This study tested a new digital platform designed to automatically identify patients in the hospital who are experiencing bleeding. Researchers worked with 40 participants to see if this computer system could accurately spot bleeding cases using patient records and test results. …