University Of Oxford

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, both with and without HIV. The goal was to see if the vaccine is safe and triggers a strong immune response in children living with HIV. The trial has be…

This study tested the Oxford COVID-19 vaccine in over 10,000 healthy adults aged 18 and older. The goal was to see if the vaccine could prevent symptomatic COVID-19 and to check for any serious side effects. The results helped confirm the vaccine's safety and effectiveness.

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 594 children aged 5 to 36 months in Mali. Researchers compared different vaccine formats and schedules, and checked if it could be given safely alongside routine childhood vaccines. The goal i…

This study tested whether oral ivermectin is safe and works for treating scabies in children weighing 5 to less than 15 kilograms (about 11 to 33 pounds). About 240 children with scabies received either ivermectin or a standard cream treatment. The goal is to provide a simpler, o…

This study tested whether sildenafil (the drug in Viagra) can reduce harmful blood flow pulsations in the brains of people who have had a stroke or mini-stroke due to small vessel disease. 75 participants took sildenafil, a similar drug (cilostazol), and a placebo for three weeks…

This study tested whether combining three malaria drugs works better than the usual two-drug treatment for uncomplicated malaria in children. Over 2,500 children across Africa took part. The goal was to see if the triple combination is safe, well-tolerated, and at least as effect…

This study looked at 192 adults with newly diagnosed moderate to severe psoriatic arthritis to see if starting stronger treatment early works better than the usual step-up approach. Participants were split into three groups: standard care, early combination drugs, or early biolog…

This study tested a special children's version of ivermectin (CHILD-IVITAB) for treating scabies in 13 children weighing between 5 and 15 kilograms (about 11 to 33 pounds). The goal was to see if the medicine is safe, how the body processes it, and if it works well in this younge…

This study tested a new type of deep brain stimulation (DBS) that adapts in real-time to a patient's needs, specifically for people with multiple system atrophy (MSA). Three participants received the adaptive DBS to see if it could improve quality of life, movement, sleep, and au…

This study tested a new diagnostic tool called iiPCR to see how well it can detect scrub typhus, a serious bacterial infection spread by mites. Researchers in Thailand enrolled 345 people with fever and compared the new test to standard methods. The goal was to find a faster, mor…

This study in Tanzania looked at whether specially designed houses can help protect children under 13 from malaria, pneumonia, and diarrhea. Over 1,100 children living in study villages were followed to see if better housing reduces these illnesses. The goal is to find simple, la…

This study looked at whether a digital sleep program called Sleepio could improve quality of life, sleep, and thinking in people with fibromyalgia. 80 participants were randomly assigned to use Sleepio or receive standard sleep advice. The goal was to see if better sleep could ea…

This study tested a wireless monitoring system that tracks vital signs like heart rate and breathing continuously, without wires or bed rest. The goal was to see if it helps hospital staff detect when surgical patients are getting worse faster than standard checks every few hours…

This study tested a program called Saving Babies' Lives in rural Cambodia to see if it could reduce newborn deaths. Over 24,000 people took part, including healthcare workers and community volunteers. The program trained staff and worked with local health groups to improve care f…

This study looked at over 1,000 adults in Northeast Thailand who were hospitalized with sepsis caught outside of a hospital. Researchers tested a newer way to define sepsis severity and tracked which germs caused the infections and how patients fared after 28 days. The goal was t…

This study looked at how people's immune systems react to proteins in mosquito saliva after being bitten. The goal was to find markers that show how much exposure people have to mosquitoes that carry malaria and dengue. Researchers used controlled mosquito bites in healthy adults…

This study looked at how a ketone drink changes blood sugar and fat processing in 12 healthy adults. Participants drank the ketone drink or a placebo, either on an empty stomach or after a meal. The goal was to understand how timing affects metabolism, which could help with condi…

This study aimed to find out why people die in rural areas of Bangladesh, Laos, Thailand, Cambodia, and Myanmar. Researchers interviewed over 3,400 family members of people who had died to learn about their symptoms and medical history. The goal was to better understand the main …

This study looked at whether adding a genetic test for spinal muscular atrophy (SMA) to the standard newborn blood spot screening is practical and accepted by families in the UK. Over 33,000 newborns were screened using leftover blood from their routine Guthrie card. The goal was…