University Of Oxford

This study tested two different malaria vaccines—one targeting the blood stage and one the liver stage—alone and in combination. 107 healthy adults and infants in The Gambia received the vaccines to check safety and immune response. The goal is to see if combining them offers bet…

This study tested the R21/Matrix-M malaria vaccine in 594 children aged 5 to 36 months in Mali. Researchers checked if the vaccine is safe and triggers an immune response, both when given alone and alongside routine childhood vaccines like measles and yellow fever. The goal is to…

This large study tested the Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19) in over 10,000 healthy UK adults aged 18 and older. The goal was to see if the vaccine safely prevents symptomatic COVID-19. Participants received either the vaccine or a control shot, and researche…

This study tested a new COVID-19 vaccine called ChAdOx1 nCoV-19 in over 1,000 healthy adults aged 18-55 in the UK. The goal was to see if the vaccine is safe, triggers an immune response, and can prevent COVID-19. Participants received either the vaccine or a comparison shot, and…

This study tested a chatbot called ParentText for Crisis, designed to support Palestinian caregivers living in a refugee camp in Jordan. The goal was to see if the chatbot could improve caregivers' mental health, encourage positive parenting, and reduce violence against children.…

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, some living with HIV and some without. The goal was to see if the vaccine is safe and produces an immune response in these children. The trial has been c…

This early-phase trial tested adding the anti-parasitic drug atovaquone to standard chemotherapy and radiation for people with locally advanced non-small cell lung cancer. The main goal was to find the safest dose of atovaquone in this combination. Twenty-one participants receive…

This study tested whether a 12-week low-carbohydrate diet program, delivered through a smartphone app with remote coaching, could help people with type 2 diabetes improve their blood sugar and lose weight. 115 adults recently diagnosed with type 2 diabetes and who were overweight…

This study tested the safety and effectiveness of oral ivermectin for treating scabies in children weighing 5 to less than 15 kilograms. 240 children participated, receiving either ivermectin, a standard permethrin cream, or a placebo. The goal is to see if ivermectin can be a sa…

This completed Phase 2 trial tested oral ivermectin minitablets in 13 children aged 3 months and older weighing 5 to less than 15 kilograms who had scabies. The study aimed to check the safety, how the drug works in the body, and how well it treats the infection. Results will hel…

This completed trial tested whether starting stronger medications early helps people with moderate to severe psoriatic arthritis more than the usual step-up approach. 192 adults were randomly assigned to standard care, early combination disease-modifying drugs, or early TNF inhib…

This study tested whether sildenafil, a drug used for erectile dysfunction, can reduce harmful pulsations in brain blood flow in 75 people who had a stroke or mini-stroke due to small vessel disease. Participants took sildenafil, a similar drug (cilostazol), or a placebo for thre…

This large Phase 3 trial tested whether combining three antimalarial drugs works better than the standard two-drug treatments for uncomplicated malaria in African children. Over 2,500 children aged 6 months to 12 years received either a triple or standard therapy. The goal was to…

This small study tested a new type of deep brain stimulation (DBS) that automatically adjusts electrical pulses based on a person's activity or body position. The goal was to improve walking, blood pressure, bladder control, and sleep in people with Multiple System Atrophy (MSA),…

This study tested a new molecular test (iiPCR) to diagnose scrub typhus, a bacterial infection spread by mites. Researchers compared the test's accuracy against standard methods in 345 participants in Thailand. The goal was to see if this tool could provide faster, reliable diagn…

This study tested whether specially built houses (Star Homes) could reduce malaria, respiratory infections, and diarrhea in children under 13 in rural Tanzania. Over 1,100 children lived either in a Star Home or a traditional mud house. The Star Homes have screened windows, solar…

This study tested whether a digital sleep therapy program called Sleepio can improve quality of life, sleep, and thinking in people with fibromyalgia. 80 participants were randomly assigned to use Sleepio or receive standard sleep advice. Researchers measured changes in symptoms …

This study tested whether a commercial meal replacement weight loss programme could reduce atrial fibrillation (AF) symptoms in overweight adults aged 60-85 with persistent AF. 119 participants were randomly assigned to either the weight loss programme or usual care for 32-36 wee…

This study tested whether an online cognitive behavioural therapy program called Sleepio could improve sleep in people who have had a stroke. 86 chronic stroke survivors were randomly assigned to either use Sleepio for 6 weeks or receive a leaflet with basic sleep tips. The main …

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study from the University of Oxford aims to understand how specific physiotherapy exercises (neurodynamic exercises) work for carpal tunnel syndrome. Researchers will compare these exercises to standard steroid injections and simple advice in 78 patients with mild to moderat…

This study tested a program called Naungan Kasih-Hybrid that combines a single in-person session, teacher-led WhatsApp groups, and a chatbot to help parents of preschoolers in low-income families in Malaysia. Over 770 parents and 750 children from 50 preschools took part. The goa…

This study tested a parenting program called Naungan Kasih that uses a chatbot, in-person teacher sessions, and WhatsApp groups to help parents of 4-6 year olds in Malaysia play and learn with their children. 208 parents took part to see which combination of tools worked best. Th…

This study looked at how a ketone drink changes blood sugar and liver fat production in 12 healthy adults, comparing when they were fasted versus after a meal. Researchers wanted to understand if the drink's effects differ based on whether you've just eaten. The goal is to learn …

This study looked at how different meningococcal vaccines affect B cells, the white blood cells that produce antibodies. Researchers gave 20 healthy adults aged 30-70 either a polysaccharide or conjugate vaccine and then measured their B cell responses. The goal was to understand…

This study looked at whether iron supplements improve how well vaccines work in pregnant women with anemia (low iron). Researchers compared their immune responses to tetanus, diphtheria, and COVID-19 vaccines against women without anemia. The goal was to see if correcting iron de…

This study tested whether 'Hope Groups'—peer-led support groups for Ukrainian caregivers affected by war—can improve mental health and reduce violence against children. Over 500 caregivers participated, with some receiving the 12-session program and others on a waitlist. The goal…

This study tested a wearable monitoring system that tracks vital signs like heart rate and breathing continuously. The goal was to see if it helps hospital staff detect when surgical patients are getting worse faster than standard checks. 240 adults on a surgical ward took part, …

This study tested a digital platform that helps hospital staff quickly identify patients who are bleeding, so they can be asked to join future research studies. About 40 adults admitted to Oxford University Hospitals took part. The goal was to see if the platform could correctly …

This University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…

This study interviewed family members of over 3,400 people who died in rural villages in Bangladesh, Laos, Thailand, Cambodia, and Myanmar. The goal was to figure out the causes of death in areas where official records are poor. Researchers used a standard questionnaire called ve…

This study tested a comprehensive neonatal healthcare package called the Saving Babies' Lives Programme in rural Cambodia. Over 24,000 participants were involved across villages and hospitals. The goal was to see if training healthcare workers and supporting community volunteers …

This study looked at how people's immune systems react to proteins in mosquito saliva after being bitten. Researchers exposed 147 healthy adults in Thailand to lab-grown mosquitoes that can carry malaria or dengue. The goal was to find markers in the blood that show how much expo…

This completed study in Thailand looked at how well the latest sepsis definition (Sepsis-3) works for patients with community-acquired sepsis. Researchers collected blood and other samples from 1002 adults at a hospital in Ubon Ratchathani. They tracked who survived for 28 days a…

This completed study looked at whether it is practical and acceptable to screen all newborns for spinal muscular atrophy (SMA), a rare genetic disease that causes muscle weakness and can be fatal if not treated early. Over 33,000 babies were screened using a simple blood spot tes…