University Of Oxford

This study aims to see if giving people half the usual amount of the R21 malaria vaccine works just as well as the full dose. Researchers will compare the immune response and safety in teens and adults receiving different doses. The goal is to find the most efficient way to use t…

This study is testing whether a new experimental rabies vaccine can be safely given at the same time as the standard licensed vaccine. Researchers want to see if this combination creates a strong immune response with fewer clinic visits. The trial will involve 40 healthy adults i…

This study is testing whether adding a purified cannabis compound called cannabidiol (CBD) can improve the effects of the antipsychotic drug clozapine for people with severe, treatment-resistant psychosis. About 250 participants who haven't responded well to clozapine alone will …

This large, international study is testing whether a two-year course of cannabidiol (CBD) can reduce early warning signs of psychosis and prevent its full onset in young people identified as being at high clinical risk. Nearly 600 participants, aged 12-35, will be randomly assign…

This study aims to see if adding cannabidiol (CBD), a non-intoxicating compound from cannabis, to standard antipsychotic medication can better control symptoms in young people experiencing their first psychotic episode. It will involve 250 participants aged 16-40 who haven't resp…

This study aims to find out why some people with depression get better with treatment while others do not. Researchers will collect detailed information from 2,000 participants, including genetic data, blood tests, and surveys about symptoms and life experiences. The goal is to u…

This study aims to understand if poor sleep quality makes mental health symptoms worse for people recovering from a brain injury, such as from a stroke or trauma. Researchers will follow 150 adults for up to a year after their injury, using wrist monitors, sleep mats, and questio…

This study aims to see if a special watch-like device worn on the ankles can reliably measure walking ability in very young boys (aged 1-3) with Duchenne muscular dystrophy (DMD). Currently, there's no good way to test how well potential new medicines work in toddlers. The study …

This study aims to see if a new blood test can track how well tuberculosis (TB) treatment is working. Researchers will measure tiny pieces of TB bacteria DNA in the blood of 140 people in Thailand before and during their treatment. The goal is to find a faster way to monitor trea…

This early study aims to understand how three malaria drugs interact when taken together. Researchers will give different combinations of these drugs to 24 healthy Thai adults in a specific order, with breaks in between. The main goal is to measure drug levels in the blood and ch…

This study aims to understand why some people get a serious bacterial infection called melioidosis and how they recover. Researchers will observe 1,000 patients in Thailand, Laos, and Cambodia for a year, comparing them to healthy neighbors and closely monitoring a high-risk vill…

This University of Oxford study aims to understand how the antidepressant Prozac (fluoxetine) affects thinking and social skills in healthy young adults. Researchers will give 80 participants aged 18-24 either a one-week course of Prozac or a placebo pill, then test their decisio…

This project is the third part of a 5-year research program entitled "Malaria Infection Studies in Thailand (MIST)" and known as MIST3. MIST3's primary objectives are to assess the safety of the PvRII/Matrix-M vaccine candidate in healthy adult Thai volunteers and to establish wh…