University Of Oxford

This phase II trial tests a new malaria vaccine called PvRII/Matrix-M in 36 healthy Thai adults aged 20-55. Half receive the vaccine, half a placebo. After three doses, 24 volunteers will be exposed to the malaria parasite in a controlled setting to see if the vaccine reduces inf…

This study tests whether a half-dose of the R21/Matrix-M malaria vaccine is as effective as the full dose in 375 adults and adolescents aged 14 to 60. Participants will receive either the standard dose or a half-dose, and researchers will measure their immune response and safety.…

This study tests a new experimental rabies vaccine (ChAdOx2 RabG) given together with the standard rabies vaccine in healthy adults aged 18-45. The goal is to see if this combination is safe and produces a strong immune response, potentially allowing a single visit instead of the…

This study tests whether adding cannabidiol (CBD) to the standard drug clozapine helps people with treatment-resistant psychosis. 250 participants will receive either CBD or a placebo for 12 weeks. Researchers will measure symptom changes and check safety.

This study tests whether cannabidiol (CBD), a non-psychoactive cannabis compound, can reduce psychotic symptoms in 586 young people (ages 12-35) at high risk for psychosis. Participants take either CBD or a placebo daily for two years. The goal is to see if CBD can ease symptoms …

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication can improve symptoms in people experiencing their first episode of psychosis who haven't responded well to initial treatment. About 250 participants aged 16-40 will receive either CBD or a plac…

This observational study will enroll 190 hospitalized adults with dengue in Bangladesh to see if a 'leaky gut' — where bacteria and toxins escape the intestines into the blood — is linked to severe disease. Researchers will measure gut leakage markers in blood, perform abdominal …

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study from the University of Oxford will follow 360 pregnant women to see if hormone levels and ultrasound images from the first 8 weeks can predict pre-eclampsia. Pre-eclampsia is a dangerous complication that affects many pregnancies worldwide. The goal is to find early wa…

This early-stage trial will give 24 healthy adults three different malaria drugs—piperaquine, pyronaridine, and artesunate—alone and together to see how they interact. Researchers will measure drug levels in the blood and watch for side effects. The goal is to learn about safety …

This study looks at why some people with hip impingement still have pain after doing physiotherapy exercises. Researchers will ask 175 adults about their emotions, fears, and pain types before and after treatment. The goal is to find hidden causes of pain, like nerve issues or an…

This study looks at how a week of Prozac (fluoxetine) changes decision-making and social thinking in 80 healthy people aged 18-24. Participants take either Prozac or a placebo, then complete tasks on emotion recognition, reward learning, and social exclusion. The goal is to bette…

This study aims to understand how the environment, the bacteria that cause melioidosis, and the human body interact to cause disease. Researchers will follow about 1,000 infected patients and 1,000 healthy matched controls in Thailand, Laos, and Cambodia for one year. They will a…

This study looks at 150 people who have had a brain injury from a stroke, bleed, or trauma. Researchers will track their sleep quality and mental health symptoms for up to a year using wrist monitors, brain activity sensors, and questionnaires. The goal is to understand if poor s…

This study will follow 2,000 adults with major depressive disorder or bipolar disorder to understand why some people get better with treatment and others do not. Researchers will collect information on symptoms, thinking abilities, genetics, metabolism, proteins, and immune marke…