New malaria vaccine candidate enters human trial in thailand
NCT ID NCT05380388
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests a new malaria vaccine called PvRII/Matrix-M in 36 healthy Thai adults aged 20-55. Half receive the vaccine, half a placebo. After three doses, 24 volunteers will be exposed to the malaria parasite in a controlled setting to see if the vaccine reduces infection. The study focuses on safety and immune response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PvRII/Matrix-M malaria vaccine
What this could lead to
If successful, this could lead to a vaccine that protects against Plasmodium vivax malaria, a major cause of illness in tropical regions.
What could go wrong
This is a small early-phase trial (36 people) testing safety and immune response, not yet proven to prevent malaria in the real world. The vaccine may not work as hoped.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Faculty of Tropical Medicine
Bangkok, 10400, Thailand
Contact Phone: •••-•••-•••• Email: •••••@•••••