Could a malaria vaccine ward off another deadly disease?
NCT ID NCT07416461
First seen Feb 26, 2026 · Last updated Jun 22, 2026 · Updated 11 times
Summary
This study looks at whether the R21/Matrix-M malaria vaccine can also reduce the risk of invasive non-typhoidal Salmonella (iNTS), a serious bacterial infection. Researchers will follow 10,000 children under 5 in the Democratic Republic of Congo who come to health centers with fever. By comparing vaccination status between those who test positive or negative for iNTS, they hope to see if the vaccine offers extra protection.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Institut National de Recherche Biomedicale (INRB)
RECRUITINGKinshasa, Democratic Republic of the Congo
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
R21/Matrix-M malaria vaccine
What this could lead to
If the malaria vaccine also lowers the risk of invasive non-typhoidal Salmonella, it could provide a dual benefit for children in malaria-endemic regions.
What could go wrong
This is an observational study, not a controlled trial, so results may show correlation rather than causation. The vaccine's effect on iNTS is not yet proven.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.