Invasive non-typhoidal salmonellosis
MONDO:0017944Invasive non-typhoidal salmonellosis (iNTS) is a rare bacterial infectious disease caused by extraintestinal infection of non-typhoidal serotypes of Salmonella enterica in patients with underlying HIV infection, malaria or malignancy. It has a high mortality rate and patients typically present with fever, pallor and respiratory signs (cough, tachnypnea, pneumonia). Gastrointestinal manifestations (diarrhea, vomit, abdominal pain) are not common. Occasionally, organ absseses, septic shock and meningitis may be observed.
Also known as: iNTS disease, invasive non-typhoidal salmonella disease
5 clinical trials for this condition and its sub-types.
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New vaccine aims to shield african infants from two deadly infections
⭐️ VACCINE ⭐️ Recruiting nowThis study is testing a new vaccine called iNTS-TCV in 537 infants in Africa. The vaccine is designed to protect against two serious bacterial infections: invasive nontyphoidal salmonella (iNTS) and typhoid fever. Researchers are giving the vaccine to infants starting at either 6…
Phase: PHASE2 • Sponsor: GlaxoSmithKline • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 12:10 UTC
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Could a malaria vaccine ward off another deadly disease?
Prevention Recruiting nowThis study looks at whether the R21/Matrix-M malaria vaccine can also reduce the risk of invasive non-typhoidal Salmonella (iNTS), a serious bacterial infection. Researchers will follow 10,000 children under 5 in the Democratic Republic of Congo who come to health centers with fe…
Sponsor: International Vaccine Institute • Aim: Prevention
Last updated Jun 27, 2026 09:05 UTC