Can a pill make your blood deadly to malaria mosquitoes?
NCT ID NCT07758985
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial tests whether a single oral dose of lotilaner, a drug currently used in animals, can make human blood lethal to Anopheles gambiae mosquitoes, the main carriers of malaria. Healthy adults in Mali will receive either a low or high dose of lotilaner or a placebo, with or without a high-fat meal. Researchers will then feed mosquitoes on participants' blood to see how many survive, while also monitoring safety and how the drug behaves in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lotilaner
- What this could lead to
- If successful, this could lead to a new way to reduce malaria transmission by making human blood temporarily lethal to mosquitoes.
- What could go wrong
- This is an early-phase trial with a small number of healthy volunteers, so safety and effectiveness are not yet established. The drug may not kill enough mosquitoes or may have side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Malaria Research and Training Center
Bamako, Mali
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