MALARIA

This study aims to develop a vaccine to prevent malaria during pregnancy. Researchers will test potential vaccines using blood samples from 7,476 pregnant women aged 15-25 in Mali, West Africa. The goal is to find a vaccine that blocks malaria parasites from attaching to the plac…

This study tests whether giving a smaller dose of the RTS,S/AS01E malaria vaccine or using a different vaccination schedule is safe and works well in healthy children aged 5 months to 5 years living in areas where malaria is common. The goal is to see if these changes can still t…

This study aims to evaluate, treat, and follow up with people who have or may have parasitic infections such as malaria, intestinal worms, or strongyloides. Participants must be at least 3 years old and will undergo physical exams, lab tests on blood, stool, or urine, and possibl…

This study tests whether giving anti-malarial drugs to everyone in a village can eliminate vivax malaria. Over 7,500 people in Peru will be split into two groups: one receiving standard care (bed nets, screening) and the other also receiving mass drug administration. The goal is …

This study looks at whether the malaria vaccine (R21/Matrix-M) can also lower the risk of invasive non-typhoidal Salmonella (iNTS) disease in children under 5. Researchers will compare vaccinated and unvaccinated children who come to clinics with fever in the Democratic Republic …

This study aims to understand why some pregnant women and young children get malaria while others don't. Researchers will follow up to 15,000 participants in Mali, collecting blood samples and health data over several years. The goal is to identify factors that influence suscepti…

This study aims to understand how malaria grows in the body, how the immune system responds, and how the parasite spreads from people to mosquitoes. Healthy adults aged 18 to 54 will be given a controlled malaria infection through donated blood. Participants will be monitored clo…

This study is collecting health information from about 9,500 women in Kalifabougou, Mali, to better understand pregnancy outcomes and malaria. Researchers will track pregnancies, malaria cases, and other health events through regular check-ups and surveys. The goal is to gather d…

This study screens healthy adults aged 18 to 50 to see if they can join future malaria vaccine, drug, or infection studies. Participants undergo medical history, physical exam, and blood/urine tests. No treatment is given in this screening study.

This study collects biological samples like blood, saliva, and urine from 300 adults aged 18-70, both with and without blood disorders such as sickle cell disease and thalassemia. The goal is to help researchers better understand these conditions and develop new tests and treatme…

This early-stage study tests a new oral drug called E1018 in 32 healthy adults to see if it is safe and how the body absorbs and removes it. Participants receive a single dose and are monitored closely. The goal is not to treat malaria but to gather essential safety data before l…

This study will test 10,000 people in Cambodia for antibodies against 57 different infectious diseases, including dengue, flu, and malaria. The goal is to map where and how these diseases spread, so health officials can design better prevention strategies. Participants must live …

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …