MALARIA

This study aims to develop a vaccine to prevent malaria during pregnancy. Researchers will test potential vaccines in the lab using blood samples from pregnant women aged 15-25 in Mali. The goal is to find a vaccine that blocks malaria parasites from attaching to the placenta.

This study is testing whether giving a smaller amount of the RTS,S/AS01E malaria vaccine or using a different vaccination schedule is safe and still triggers a strong immune response. It involves 238 healthy children aged 5 months to 5 years living in an area where malaria is com…

This study is for people age 3 and older who have or may have a parasitic infection, such as malaria or intestinal worms. Participants will receive standard medical tests and treatments—no experimental drugs are involved. The goal is to diagnose, treat, and monitor the infection …

This study looks at whether the malaria vaccine (R21/Matrix-M) can also lower the risk of invasive non-typhoidal Salmonella (iNTS) disease in children under 5. Researchers will compare vaccinated and unvaccinated children who come to health centers with fever in the Democratic Re…

This study tests whether giving anti-malarial drugs to everyone in a village can reduce new cases of vivax malaria. Over 7,500 people in Peru will take part. Some villages will get the drugs, while others will only receive standard care like bed nets and testing. The goal is to s…

This study tests whether a single dose of L9LS, a lab-made antibody, can safely prevent malaria in women aged 18-49 in Mali. About 290 participants will receive either the antibody or a placebo and be monitored for infections and side effects over 24 weeks. The goal is to find a …

This early-stage study tests a new oral drug called E1018 in 32 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose and are monitored for side effects and drug levels in blood and urine. This study does not aim to treat or prevent…

This study follows 380 children in Uganda for 2 years to see how well malaria and HIV treatments work together. Half the children have HIV and half do not. Researchers will measure changes in body weight, drug levels, and blood sugar to find the best treatment plans.

This study will follow about 9,500 women of childbearing age in Kalifabougou, Mali, to track pregnancy outcomes and malaria infections. Researchers will collect data through regular health visits and surveys, but no new treatments or drugs are being tested. The goal is to better …

This study aims to learn why some pregnant women and young children get malaria while others don't, by tracking up to 15,000 participants in Mali over several years. Researchers will collect blood samples and health data to identify immune and parasite factors linked to infection…

This study collects biological samples like blood, saliva, and urine from people with blood disorders (such as sickle cell disease and thalassemia) and healthy volunteers. The goal is to help researchers better understand these conditions and related diseases like malaria. Partic…

This study will test 10,000 people in Cambodia for antibodies to over 50 different infectious diseases, including dengue, flu, and malaria. The goal is to map where and how these diseases spread in communities, involving people aged 2 to 75 who have lived in a village for at leas…

This study aims to understand how malaria develops in the body and how it spreads from people to mosquitoes. Healthy adults aged 18 to 54 will be infected with a malaria parasite through donated blood and closely monitored. Participants will stay at the clinic for several days, h…

This study screens healthy adults aged 18 to 50 to see if they can join future malaria research trials. The goal is to find safe and effective malaria vaccines, drugs, or prevention methods. Participants will have a medical history check, physical exam, and blood and urine tests.…