Healthy volunteers bitten by mosquitoes in malaria experiment

NCT ID NCT06607003

First seen Jun 26, 2026 · Last updated Aug 04, 2026 · Updated 8 times

Summary

This study gives healthy adults a controlled malaria infection using donated blood containing the P. vivax parasite. Researchers will monitor how the infection develops, how the immune system responds, and whether mosquitoes can pick up the parasite from participants. The goal is to create a safe model for testing future vaccines and treatments. Participants will take chloroquine to clear the infection and will have follow-up visits for three weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
P. vivax malaria parasite in donated blood
What this could lead to
If successful, this could provide a safe model to test future malaria vaccines and treatments, and help understand how the parasite spreads.
What could go wrong
This is an early-phase study with only 300 participants, focused on observation, not treatment. Participants will get malaria symptoms and must stay in the clinic for several days.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

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