MALARIA

This study tested an experimental RNA vaccine (BNT165e) to prevent malaria in 163 healthy adults who had never had malaria. Participants received different doses of the vaccine and were later exposed to malaria in a controlled setting to see if the vaccine could protect them. The…

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, both with and without HIV. The goal was to see if the vaccine is safe and triggers a strong immune response in children living with HIV. The trial has be…

This study tested the RTS,S/AS01E malaria vaccine in over 77,000 young children across sub-Saharan Africa. Researchers checked the vaccine's safety and how well it prevents malaria as part of routine childhood shots. The goal is to protect children from this serious disease.

This early-stage trial tested a new vaccine (PRIMVAC) designed to prevent malaria in pregnant women. It involved 68 healthy adults in France and Burkina Faso to check safety and immune response. Participants received three doses of the vaccine with different adjuvants to boost ef…

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 594 children aged 5 to 36 months in Mali. Researchers compared different vaccine formats and schedules, and checked if it could be given safely alongside routine childhood vaccines. The goal i…

This study tested a new vaccine designed to stop the malaria parasite from spreading from people to mosquitoes. 105 healthy adults received three doses of the vaccine over a month. The main goal was to check safety and see if the vaccine triggers an immune response. No one was ex…

This early-stage trial tested a new RNA-based vaccine designed to protect against malaria. Sixty healthy adults received different doses of the vaccine or a placebo to check for safety and immune response. The study was completed and will help decide if larger trials should move …

This study tested giving a single dose of the drug tafenoquine to everyone in three villages in Myanmar to control malaria. Over 1,200 people took part. The goal was to see if this approach is safe and practical, and if it could reduce malaria cases in the area.

This study tested whether finding and treating low-density malaria infections (infections with very few parasites) in children can improve their long-term health and reduce illness. Researchers followed 600 children in Tanzania, comparing those who received treatment for these hi…

This study tested whether giving malaria medicine to everyone in a community, even those without symptoms, could lower malaria rates in children under 15 and pregnant women. Over 3,300 people took part. The goal was to clear the malaria parasite from the community to stop mosquit…

This study tested whether giving pregnant women a combination of two malaria drugs (sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine) every 4 weeks works better than either drug alone to prevent malaria and reduce serious birth problems like low birth weight, preterm…

This study tested a single injection of a lab-made antibody called L9LS in healthy Kenyan children aged 5 months to 10 years. The goal was to see if it is safe and can protect against malaria caused by the Plasmodium falciparum parasite. Over 900 children took part, and researche…

This study tested two kinds of long-lasting insecticide-treated bed nets to see which better prevents malaria in Uganda. Over 200,000 people took part, and researchers tracked malaria cases at health clinics. The goal is to find the most effective net to protect communities from …

This large study tested giving infants a full course of antimalarial medicine (sulfadoxine-pyrimethamine) alongside their routine vaccinations during the first two years of life. The goal was to prevent malaria, which is especially dangerous for young children. Over 94,000 infant…

This study tested a new experimental drug called MMV367 in 12 healthy adults who were intentionally infected with the malaria parasite. The goal was to see how the drug works in the body and how well it clears the parasite. Participants were closely monitored and given standard m…

This study surveyed 222 healthcare workers in Sudan to understand what they know and think about the malaria vaccine. The goal is to find gaps in knowledge and attitudes so that better training and awareness programs can be created. By improving healthcare workers' confidence in …

This study looked at how people's immune systems react to proteins in mosquito saliva after being bitten. The goal was to find markers that show how much exposure people have to mosquitoes that carry malaria and dengue. Researchers used controlled mosquito bites in healthy adults…

This study in Cameroon followed 406 adults with and without type 2 diabetes for one year to see if diabetes increases the risk of malaria and other parasitic infections. Researchers tested blood and stool samples at four time points. The goal was to understand how diabetes and re…

This study aimed to measure how common malaria and worm infections are in pregnant women and children in two counties of Liberia. Over 1,200 participants gave a small blood sample and answered health questions. The results help doctors understand the local disease burden and impr…

This study aimed to measure how often people of all ages in Sabou, Burkina Faso, get malaria over one year. Researchers tracked infections in 608 healthy volunteers aged 6 months to 65 years through monthly blood tests and surveys. The information gathered will help design better…