New RNA vaccine takes aim at malaria in first human test

NCT ID NCT05581641

First seen Nov 01, 2025 · Last updated Jun 16, 2026 · Updated 30 times

Summary

This early-stage trial tested a new RNA-based vaccine designed to protect against malaria. Sixty healthy adults received different doses of the vaccine or a placebo to check for safety and to see if it triggers an immune response. The study focused on finding a safe dose and monitoring side effects like injection site pain or fatigue.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Alliance for Multispecialty Research, LLC

    Tempe, Arizona, 85281, United States

  • Alliance for Multispecialty Research, LLC

    Las Vegas, Nevada, 89119, United States

  • Alliance for Multispecialty Research, LLC

    Knoxville, Tennessee, 37909, United States

  • Clinical Trials of Texas, Inc.

    San Antonio, Texas, 78229, United States

  • University of Maryland, Center for Vaccine Development

    Baltimore, Maryland, 21201, United States

Conditions

The condition(s) this trial relates to.

malaria Plasmodium falciparum malaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.