New malaria vaccines show promise in protecting indonesian soldiers
NCT ID NCT03503058
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two experimental malaria vaccines in 345 healthy Indonesian soldiers deployed to a malaria-endemic region. One vaccine uses weakened malaria parasites, and the other uses live parasites with a preventive drug. The goal was to see if either vaccine could safely prevent natural malaria infection. Results will help determine if these vaccines can protect people in high-risk areas.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Two malaria vaccines: PfSPZ Vaccine (weakened malaria parasites) and PfSPZ-CVac (live malaria parasites given with chloroquine to prevent infection)
- What this could lead to
- If successful, this could lead to an effective vaccine that protects people living in or traveling to malaria-endemic areas from getting sick.
- What could go wrong
- This is a phase 2 trial with 345 participants, so results may not apply to larger populations. The vaccines may not provide strong or lasting protection, and side effects like fever or injection site reactions are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Internal Medicine, Universitas Indonesia
Jakarta, 10430, Indonesia
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Eijkman-Oxford Clinical Research Unit, Eijkman Institute of Molecular Biology
Jakarta, 10430, Indonesia
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