RNA vaccine takes on malaria: early trial shows promise
NCT ID NCT06069544
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested an experimental RNA-based vaccine called BNT165e to see if it can prevent malaria. 163 healthy adults who had never had malaria received either the vaccine or a placebo. Researchers measured safety, immune responses, and whether the vaccine protected against a controlled malaria infection. The goal is to develop a new tool to fight malaria, a disease that affects millions worldwide.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BNT165e (RNA-based malaria vaccine)
- What this could lead to
- If successful, this could lead to a new vaccine to prevent malaria, a major global health threat.
- What could go wrong
- This is an early-phase trial with only 163 participants, so results may not apply broadly. The vaccine may not provide strong or lasting protection, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AMR Knoxville
Knoxville, Tennessee, 37909, United States
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AMR Las Vegas
Las Vegas, Nevada, 89119, United States
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AMR Tempe
Tempe, Arizona, 85281, United States
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Clinical Trials of Texas
San Antonio, Texas, 78229, United States
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University of Maryland, Center for Vaccine Development
Baltimore, Maryland, 21201, United States
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