New drug combo could cut malaria risks in pregnancy
NCT ID NCT04336189
First seen Nov 06, 2025 · Last updated Jun 22, 2026 · Updated 34 times
Summary
This large phase 3 trial tested whether combining two malaria drugs (SP and DP) works better than either alone to prevent malaria and improve birth outcomes in pregnant women. Over 2,700 HIV-negative women in Uganda received monthly doses of SP, DP, or both. The study tracked complications like low birth weight, preterm birth, and stillbirth to find the safest and most effective regimen.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MALARIA are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Infectious Diseases Research Collaboration Clinic - Masafu Hospital
Masafu, Busia, Uganda
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sulfadoxine-pyrimethamine (SP) and dihydroartemisinin-piperaquine (DP)
What this could lead to
If successful, this could lead to a more effective preventive treatment for malaria during pregnancy, reducing risks like low birth weight and preterm birth.
What could go wrong
The trial is completed but results are not yet widely confirmed. The combination may cause more side effects or not work better than existing treatments.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.