MALARIA

This study is testing whether giving children a lower dose of an existing malaria vaccine, or giving it on a different schedule, is safe and still helps their bodies build protection. It involves 238 healthy children, aged 5 months to 5 years, who live in an area where malaria is…

This study is testing potential vaccines to prevent malaria infections during pregnancy, which can be dangerous for both mother and baby. Researchers are collecting blood samples from about 2,500 pregnant women in Mali who have malaria. They'll use these samples in lab tests to s…

This National Institutes of Health study aims to evaluate and treat people with known or suspected parasitic infections like malaria or intestinal worms. Participants receive standard medical care, including exams, lab tests, and appropriate treatments for their specific conditio…

This study is testing a focused strategy to control a type of malaria in Peru. It will involve over 7,500 people across many villages. Researchers will compare giving preventive anti-malaria drugs to people living near recent cases against the current standard of care, which incl…

This study aims to find the safest and most effective malaria treatments for children, especially those also living with HIV. Researchers in Uganda will follow 380 children for two years, comparing two common malaria drugs and checking how they interact with HIV medication. The g…

This study is testing if a single injection of an antibody called L9LS can safely prevent malaria infection. It will involve 290 adults, primarily women of childbearing age in Mali, who will receive either the antibody or a placebo. Researchers will monitor participants for six m…

This study aims to find out if a new malaria vaccine given to young children can also reduce their risk of getting a severe bacterial infection called invasive non-typhoidal Salmonella (iNTS). Researchers will observe 10,000 children under age 5 in the Democratic Republic of Cong…

This study aims to understand how 57 different infectious diseases spread in Cambodian communities. Researchers will survey 10,000 people and test their blood to see which diseases they have been exposed to. The goal is to gather information to help public health officials design…

This study aims to gather detailed information about pregnancy and malaria in a community in Mali. Researchers will follow up to 9,500 women of childbearing age and their babies for several years to track health outcomes. The data collected will help plan future clinical trials t…

This is the first study to test a new oral drug called E1018 in people. Researchers will give single, increasing doses to 32 healthy adults to check for safety and see how the body absorbs and eliminates the drug. The goal is to gather initial data to see if the drug is safe enou…

This study aims to understand how malaria develops in people and how it spreads from humans to mosquitoes. Healthy volunteers will be intentionally infected with a malaria parasite via an injection of donated blood, then closely monitored as they develop symptoms. Researchers wil…

This study aims to screen healthy adults to see if they are eligible to join future research trials for malaria vaccines, new drugs, or prevention methods. Participants will undergo medical history reviews, physical exams, and lab tests to ensure they are suitable candidates. The…

This study aims to understand why some pregnant women and young children in Mali get severe malaria while others don't. Researchers will follow thousands of mothers and children over several years, collecting health and blood sample data. The goal is to gather knowledge that can …

This study aims to collect biological samples like saliva, blood, urine, and small tissue samples from volunteers to help scientists better understand blood disorders such as sickle cell disease, thalassemia, and malaria. Researchers need samples from both healthy adults and thos…