Can CBD boost clozapine for Treatment-Resistant psychosis?
NCT ID NCT07326124
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding cannabidiol (CBD) to the standard drug clozapine helps people with treatment-resistant psychosis. 250 participants will receive either CBD or a placebo for 12 weeks. Researchers will measure symptom changes and check safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cannabidiol (CBD) oral solution
What this could lead to
If it works, this could offer a new add-on option for people with psychosis who don't respond well to standard clozapine treatment.
What could go wrong
This is a phase 3 trial, but it hasn't started recruiting yet. CBD may not improve symptoms more than placebo, and side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Cambridgeshire and Peterborough NHS Foundation Trust
Cambridge, United Kingdom
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Charité Universitätsmedizin
Berlin, Germany
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Geha Mental Health Center
Petah Tikva, Israel
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Hospital General Universitario Gregorio Marañón
Madrid, Spain
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Hospital Universitario Virgen del Rocío
Seville, Spain
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Ludwig-Maximilian-University Munich
Munich, Germany
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National and Kapodistrian University of Athens
Athens, Greece
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Oxford Health NHS Foundation Trust
Oxford, United Kingdom
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Psychiatric University Hospital (PUK), Zurich
Zurich, Switzerland
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Shalvata Mental Health Center
Hod HaSharon, Israel
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Sheba Medical Centre
Ramat Gan, Israel
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Stichting Amsterdam UMC
Amsterdam, Netherlands
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University Hospital Cologne
Cologne, Germany
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University of Campania 'Luigi Vanvitelli'
Naples, Italy
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West London NHS Trust
London, United Kingdom