Could a simple vitamin help pregnant women with high blood pressure?

NCT ID NCT05434195

Recruiting now Disease control Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a special form of folic acid (5-MTHF) can improve blood vessel health in pregnant women with high blood pressure or pre-eclampsia. Researchers will measure key molecules in the blood, placenta, and umbilical cord to see if the supplement helps. The trial involves 128 women and aims to understand how the supplement affects the body, not to cure the condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 5-methyltetrahydrofolate (a form of folic acid)
What this could lead to: If it works, this could point toward a simple nutritional supplement to help manage high blood pressure in pregnancy and protect the heart health of mothers and their babies.
What could go wrong: This is a small, early-stage study focused on measuring biological markers, not on preventing or curing the condition. The supplement may not lead to clear health improvements, and results may not apply to all pregnant women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertension, pregnancy-induced preeclampsia pregnancy disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRE-ECLAMPSIA PREGNANCY INDUCED HYPERTENSION PREGNANCY RELATED

Contacts and locations

Locations

Cardiovascular Clinical Research Facility
RECRUITING

Oxford, Oxfordshire, OX3 7RD, United Kingdom
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, Oxfordhsire, OX3 9DU, United Kingdom

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