Pregnancy disorder

This study tests whether a real-time continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes keep their blood sugar in a healthy range better than standard finger-prick testing. About 240 women in early pregnancy will either wear the CGM device for most of thei…

This study compares a repeat curettage (a scraping procedure inside the uterus) against standard chemotherapy with methotrexate as the first treatment for women with low-risk gestational trophoblastic neoplasia, a rare cancer that can develop after a molar pregnancy. The goal is …

This study will give 800 pregnant women biweekly food kits with fruits, vegetables, and other healthy foods to see if it improves their diet and pregnancy outcomes. Participants will be followed from early pregnancy through birth. The goal is to learn whether providing healthy fo…

This study compares three surgical techniques for managing placenta accreta, a condition where the placenta grows too deeply into the uterine wall. The goal is to find which method causes the least blood loss during delivery. The trial will enroll 42 pregnant women with this cond…

This study tests whether a continuous glucose monitor (CGM) paired with a coaching app helps pregnant women with type 2 diabetes achieve better blood sugar control compared to standard care. Participants use a Dexcom G7 CGM sensor and receive guidance through a mobile app and car…

This study tests whether providing money specifically for healthy foods helps pregnant women avoid gaining too much weight. About 1,440 women will either get standard nutrition advice or that plus up to $3,000 for healthy groceries. Researchers will compare weight gain between th…

This study tests whether community-based patient navigators can improve maternal health for Black women in a safety-net health system. 540 pregnant women with unmet social needs will be randomly assigned to receive either standard care or extra support from a navigator from mid-p…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study tests a decision aid—a tool that provides information and goal-setting exercises—to help women who had high blood pressure during pregnancy take steps to protect their heart health after childbirth. The goal is to improve engagement in preventive care like blood pressu…

This study compares two treatments for gestational diabetes: oral metformin pills and injectable insulin. Researchers want to see if metformin is as good as insulin at preventing problems for mothers and babies, like high birth weight or low blood sugar. About 1,500 pregnant wome…

This study tests whether wearing a continuous glucose monitor (CGM) helps pregnant women with gestational diabetes control their blood sugar and improve outcomes for both mother and baby. Researchers will also examine how socioeconomic status, diet, and culture affect results. Th…

This study tests if leg exercise (like pedaling) is better than arm exercise for controlling blood sugar, weight, and stress in pregnant women with gestational diabetes. 108 women in their second trimester will exercise three times a week for eight weeks. The goal is to find a sa…

This study tests a short counseling program (about 4 sessions) designed to help pregnant and postpartum women in Cape Town, South Africa, keep taking their daily HIV-prevention pill (PrEP). Many women stop PrEP due to depression or trauma from violence. The program uses cognitive…

This study tests whether giving DHA (a type of omega-3 fat) early to very preterm infants who are small at birth can improve head growth without causing too much fat gain. The trial will include 152 infants and measure head size and body fat at 36 weeks adjusted age. If successfu…

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metfo…

This study tests whether a combination of nifedipine and enalapril controls high blood pressure after childbirth better than nifedipine and labetalol. It involves 200 postpartum women with persistent hypertension. The goal is to reduce hospital stays, readmissions, and severe blo…

This study looks at whether starting hepatitis C treatment during pregnancy is feasible and acceptable for women who have used drugs. Fifty pregnant adults with hepatitis C will take glecaprevir-pibrentasvir daily for 56 days. Researchers will track how well participants stick to…

This study tests whether a continuous glucose monitor (CGM) can improve pregnancy outcomes for women with gestational diabetes compared to standard finger-prick testing. About 386 women from Belgium and Australia will be randomly assigned to use either a CGM or a regular glucomet…

This study compares two common blood pressure medications, labetalol and nifedipine, in 110 new mothers with postpartum hypertension. The goal is to see which drug controls blood pressure better and reduces the need for ongoing medication beyond six weeks after delivery. Particip…

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test an…

This study tests a program that gives food supplements to pregnant women, new mothers, and their babies, along with advice on healthy eating, exercise, and infant feeding. The goal is to reduce both maternal obesity and child stunting in rural Indigenous communities in Guatemala.…

This study compares two mobile health strategies for managing high blood pressure after pregnancy. 770 new mothers with pregnancy-induced hypertension will use either a 12-week or 10-day text-based blood pressure monitoring program. The goal is to see which approach better lowers…

Thick meconium in the amniotic fluid affects about 1 in 7 pregnancies and can cause breathing problems in newborns. The PEARL trial tests whether infusing warm sterile fluid into the uterus during labor reduces these risks. The study will enroll 320 pregnant people at 36 weeks or…

This study looks at whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. About 150 participants will be randomly assigned to use their usual AID system or standard intravenous insulin. T…

This early-stage trial tests a single injection of CBP-4888 in 60 pregnant women hospitalized with preterm preeclampsia, a serious condition involving high blood pressure and organ stress. The goal is to find a safe dose and see if the drug can lower a harmful protein called sFlt…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study compares taking insulin glargine once versus twice daily in pregnant women with type 2 diabetes who need insulin. Two hundred participants will be randomly assigned to one of the two dosing schedules, and their blood sugar levels will be tracked continuously. The goal …

This pilot study tests a conservative management strategy for placenta accreta, a serious pregnancy complication where the placenta grows too deeply into the uterine wall. Instead of the standard treatment—a hysterectomy (removing the uterus) after a C-section—doctors will leave …

This study tests if the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. Researche…

This study tests a new once-weekly growth hormone injection (inpegsomatropin) against the standard daily growth hormone shot in 141 children born small for gestational age who remain short. The goal is to see if the weekly shot works as well or better at helping kids grow taller …

This study tests whether taking a daily low-dose aspirin for six months after childbirth can improve heart function in women who had preeclampsia. Preeclampsia can raise a protein called Activin A, which may harm the heart. The trial will compare aspirin to a placebo in 180 women…

This study tests whether community health workers can help women in urban slums of India get screened for type 2 diabetes after having gestational diabetes. 330 women will either receive home-based testing or a referral to a clinic, plus diabetes education. A smaller part of the …

This study tests whether a single IV dose of diphenhydramine, an antihistamine, can prevent labor from stalling and reduce the need for C-sections in first-time mothers. Researchers will enroll 200 women in active labor with cervical edema. The goal is to see if the drug helps th…

This study tests whether adding a 10-week health coaching program from a community health worker to remote blood pressure monitoring helps women who had high blood pressure during pregnancy. 240 women will be followed for 6 months after delivery. The goal is to see if the combine…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This pilot study is testing whether giving progesterone (17 OHPC) to pregnant women diagnosed with preeclampsia before 34 weeks can improve outcomes for both mother and baby. The study will enroll 60 participants at the University of Mississippi Medical Center. Researchers will m…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm, skin, and placenta to see if MitoQ helps restore normal function and pr…

This study tests a structured behavioral program called the BMW Toolkit for pregnant women with both gestational diabetes and pregnancy-induced hypertension. The toolkit includes diet, exercise, sleep, and self-care guidance delivered over 7-8 sessions. Researchers will compare b…

This study tests if a once-weekly injection of somatrogon works as well as a daily growth hormone shot for children with short stature. It includes 254 children born small for their age or with no clear cause for their short height. The goal is to see if the weekly option can imp…

This Phase 2 trial tests ravulizumab (Ultomiris) in 14 pregnant individuals with severe preeclampsia or HELLP syndrome before 34 weeks of pregnancy. The drug aims to block part of the immune system that may drive these dangerous conditions. Researchers will measure blood markers …

This study looks at whether a special form of folic acid (5-MTHF) can improve blood vessel health in pregnant women with high blood pressure or pre-eclampsia. Researchers will measure key molecules in the blood, placenta, and umbilical cord to see if the supplement helps. The tri…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This study tests whether a natural substance called inorganic nitrate can safely lower blood pressure in pregnant women with chronic hypertension. About 144 women will receive either nitrate or a placebo from the second trimester onward. The goal is to see if nitrate reduces the …

This study tests whether delivering medically tailored groceries to the homes of pregnant women on Medicaid can reduce food insecurity and improve birth outcomes like preterm birth and low birth weight. About 360 pregnant women in Cuyahoga County, Ohio, will receive home-delivere…

This large study in North Carolina tests whether giving clinics data tools and racial equity training, plus offering doula support to high-risk Black patients, can reduce low birthweight and discrimination in prenatal care. About 60,000 patients from 39 clinics will take part. Th…

This study tests whether a single daily dose of long-acting insulin can control blood sugar as well as the usual regimen of long-acting insulin plus mealtime insulin in pregnant women with diabetes. About 176 participants will be randomly assigned to one of the two approaches and…

This study tests whether a simple procedure called membrane stripping (where a doctor sweeps a finger around the cervix to separate the amniotic sac) works as well as a balloon catheter to ripen the cervix before inducing labor. About 400 full-term pregnant women will be randomly…

This phase 3 trial is testing whether adding a single dose of azithromycin to standard antibiotics can prevent infections in 8,000 women having scheduled C-sections. Participants receive either azithromycin or a placebo, plus usual care. The study tracks infections like wound inf…

This study tests whether treating mild high blood pressure (stage 1 hypertension) during pregnancy can improve baby birth weight. 74 pregnant people with blood pressure between 130-139/80-89 mmHg will be randomly assigned to either active treatment with blood pressure medication …

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study tests whether spironolactone, a blood pressure pill, can help women who had high blood pressure during pregnancy avoid long-term heart issues. About 200 women with overweight and recent hypertensive pregnancy will take the drug or a placebo daily for 12 weeks after del…

This study tests a home blood pressure monitoring program for 1,200 women in Nigeria who had high blood pressure during pregnancy. The program includes patient education, home BP monitors, follow-up care, and free medication if needed. Researchers want to see if this approach lea…

This study tests whether adding certolizumab (Cimzia) to standard care (heparin and aspirin) can prevent fetal death or early delivery in pregnant women with antiphospholipid syndrome (APS) and lupus anticoagulant. About 55 women will receive the drug early in pregnancy and be co…

This study looks at whether giving platelet transfusions only when levels are very low can help extremely premature babies (born at 23-26 weeks) survive without major bleeding. About 2,400 infants will be randomly assigned to a lower or higher transfusion trigger. The goal is to …

This study tests a cloud-connected blood pressure monitoring program for new mothers with high blood pressure disorders. The goal is to see if remote monitoring helps more women track their blood pressure after giving birth and reduces hospital readmissions. About 540 pregnant an…

This study compares two methods of removing the fallopian tubes during a C-section for permanent sterilization: using a hand-held bipolar energy tool versus traditional stitches. Researchers will look at blood loss, completion rates, and costs in 900 women who had the procedure b…

This study tests if dapagliflozin, a diabetes drug, can reduce heart and blood vessel risks in women who had high blood pressure during pregnancy. About 200 participants will take either the drug or a placebo daily for six months after delivery. The goal is to see if the drug imp…

This study tests whether a daily dose of pravastatin, a common heart medication, can safely prolong pregnancy in women diagnosed with severe early-onset preeclampsia or fetal growth restriction. The trial will include 154 pregnant women between 24 and 30 weeks of gestation, rando…

This study looks at different treatments for early missed abortion, where a pregnancy stops developing but the body doesn't expel the tissue. Researchers will compare surgery and medication, and also test if adding estrogen helps. The goal is to find the safest and most effective…

This study tests whether giving regular blood transfusions during pregnancy can reduce sickle cell complications and pregnancy-related problems in women with sickle cell disease. About 50 pregnant women will be randomly assigned to receive transfusions or standard care. The goal …

This study tests whether using a tourniquet (a tight band) around the lower uterus during surgery for placenta accreta can improve newborn Apgar scores. Placenta accreta is a condition where the placenta doesn't detach after birth, causing severe bleeding. The trial will involve …

This trial tests the safety of tolvaptan, a drug that helps the body remove extra water, in 20 children aged 28 days to 18 years with autosomal recessive polycystic kidney disease (ARPKD). The goal is to see if the drug can slow kidney function decline and reduce the need for dia…

This study tests a new weekly growth hormone injection (PEG-rhGH) against the standard daily shot in 72 short children born small for gestational age. The children, aged 3 and up with no puberty signs, will receive either a low or high weekly dose or a daily dose for 26 weeks. Th…

This study tests whether combining two drugs, camrelizumab and apatinib, with standard chemotherapy can help women with a rare but aggressive pregnancy-related cancer called gestational trophoblastic neoplasia (GTN). The trial includes two groups: those with ultra high-risk disea…

This study tests whether giving pasteurized donor human milk to full-term babies of mothers with diabetes during the first five days of life can reduce the number of infants admitted to the neonatal unit for low blood sugar. About 1,444 mothers and their newborns will be randomly…

This study compares two common blood pressure medications, Nifedipine and Labetalol, to see which works better and is safer for women who develop high blood pressure after giving birth. About 500 new mothers will be randomly assigned to one of the two drugs. The goal is to reduce…

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy better than the current standard antibiotics in pregnant people hospitalized after their water breaks early (before 34 weeks). About 56 participants wil…

This study tests whether a lifestyle program delivered through a mobile app, combined with a continuous glucose monitor (Abbott FreeStyle Libre 2), can improve blood sugar control and reduce cardiometabolic risk in 120 pregnant women diagnosed with gestational diabetes. Participa…

This study is testing whether taking a low-dose aspirin (81 mg) daily for three weeks after giving birth can improve blood vessel function in women who had severe preeclampsia. About 100 women will be randomly assigned to receive either aspirin or a placebo. The main goal is to s…

This study tests whether treating asymptomatic bacteriuria (a bladder infection with no symptoms) in pregnant women can reduce the number of preterm births, stillbirths, and underweight babies. Over 1,100 pregnant women in seven low- and middle-income countries will receive eithe…

This study tests whether an automated insulin delivery system (CamAPS FX) can help women with type 1 diabetes maintain better blood sugar control before and during pregnancy, compared to their usual insulin routine. The trial will enroll 305 women aged 18-45 who are either planni…

This study tests whether a more intensive approach—combining a structured low-calorie diet, moderate exercise, and frequent monitoring—works better than standard counseling for managing gestational diabetes. Sixty pregnant women will be randomly assigned to one of two groups. The…

This study tests whether a 6-month lifestyle program (diet, exercise, coaching) or the drug metformin is better for weight loss in mothers who recently had gestational diabetes. Sixty women who gave birth in the last year will join. Participants track their activity and weight, a…

This study tests whether giving pregnant people at risk of preterm birth half the usual dose of a steroid (Celestone) works as well as the full dose to prevent serious health problems in their babies. About 3,250 participants will receive either one or two doses after an initial …

This study tests whether wearing a continuous glucose monitor (CGM) early in pregnancy can quickly detect and manage high blood sugar in 6,000 pregnant women. The goal is to reduce serious problems for the baby (like being too large, birth injuries, or NICU stays) and for the mot…

Women who had preeclampsia are four times more likely to develop heart disease later in life, possibly due to lasting blood vessel damage. This early-phase trial tests whether taking low-dose aspirin (162 mg daily) can improve blood vessel function in 40 women who had preeclampsi…

The ACHIEVE trial is testing whether giving pregnant women with preeclampsia or high blood pressure medication to keep their blood pressure below 140/90 mmHg can safely prolong their pregnancy. The study will enroll 132 women between 23 and 35 weeks of pregnancy who have mild for…

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This study tests whether giving iron through a vein (IV) early in the second trimester works better than iron pills for treating anemia in pregnancy. About 80 pregnant women with mild iron deficiency will be randomly assigned to one of the two treatments. The goal is to see which…

This trial tests a new device called the Yaari Extractor for shoulder dystocia, a birth complication where the baby's shoulder gets stuck. The device is designed to help doctors safely and quickly deliver the baby. The study will enroll 80 pregnant women planning vaginal birth an…

This early-phase study tests whether a woman's own natural killer cells, processed in a lab and infused into her uterus, can improve uterine immune function and lead to successful pregnancy. It includes 14 women with a history of recurrent miscarriage, failed IVF, unexplained inf…

This study looks at two common blood pressure drugs, nifedipine and enalapril, to see how well they control high blood pressure in women after giving birth. About 850 women with pregnancy-related or chronic high blood pressure will be randomly assigned to one of the medicines. Th…

This study tests whether taking atorvastatin (a statin) for 3 months after childbirth can reduce the long-term risk of heart disease in women who had high blood pressure disorders during pregnancy. 76 postpartum women will receive either atorvastatin or a placebo, and their cardi…

This pilot study at Johns Hopkins University will enroll 40 Black women who recently had gestational diabetes and are overweight. Half will receive prepared low-carb, low-fat meals plus nutrition counseling, lactation support, and culturally tailored food bundles; the other half …

This study looks at whether a moderate carbohydrate diet (up to 120g per day) can help pregnant women with diabetes who need insulin achieve better blood sugar control compared to the standard high-carb diet. The trial will include 120 pregnant women and track their glucose level…

This study tests whether wearing a continuous glucose monitor that shows real-time blood sugar levels on a smartphone app, plus joining a group chat with other pregnant women, helps keep glucose levels healthy during pregnancy. About 70 pregnant women at risk for gestational diab…

This study tests whether bromocriptine, a drug that stops breastfeeding, can improve heart function in women newly diagnosed with peripartum cardiomyopathy (a type of heart failure after childbirth). 200 women will receive either bromocriptine or a placebo, plus standard heart fa…

This study tests whether tiny particles from stem cells, called exosomes, can repair blood vessel damage in women who had preeclampsia during pregnancy. Preeclampsia raises the risk of heart disease later in life, and current treatments don't fully heal the blood vessels. The tri…

This study tests whether giving a single 2-gram dose of azithromycin before starting labor induction can lower the risk of infections in both the mother and newborn. Researchers plan to enroll 400 pregnant women in their third trimester who are scheduled for labor induction. Half…

This study tests if lying on your side with a peanut ball between your legs during labor can help babies turn to the right position and reduce the need for C-sections or forceps delivery. 200 pregnant women with babies facing the wrong way will be randomly assigned to this positi…

This study is tracking 2,600 Chinese children with growth disorders who are receiving a long-acting growth hormone injection. The goal is to see how well it works and how safe it is over the long term in real-world settings. Researchers will measure changes in height and look for…

This study tests whether a smartphone-based AI ultrasound, operated by health workers with minimal training, can accurately estimate gestational age, detect placenta position, and identify fetal presentation in pregnant women in rural Democratic Republic of the Congo. The goal is…

This trial investigates whether advanced MRI scans can better detect placenta adhesion abnormalities (PAA) in pregnant women between 30 and 38 weeks. PAA occurs when the placenta grows too deeply into the uterine wall, raising risks of severe bleeding and emergency hysterectomy d…

This study aims to improve early detection of preeclampsia, a dangerous pregnancy condition. Researchers will collect blood samples from over 6,500 pregnant women between 11-14 weeks of pregnancy and compare the results with pregnancy outcomes. The goal is to see how well a new b…

This study is testing a new artificial intelligence (AI) system that reads ultrasound videos to help doctors diagnose placenta accreta spectrum (PAS), a condition where the placenta grows too deeply into the womb. About 561 pregnant women aged 18-45 with certain risk factors will…

This study tests whether the Withings BPM Pro 2, an automatic blood pressure cuff, gives accurate readings for pregnant women, including those with high blood pressure or pre-eclampsia. About 45 participants will have their blood pressure measured with both the device and a stand…

This study is testing a new blood test called the MaiRa Preeclampsia Test to see if it can accurately predict preeclampsia early in pregnancy. Preeclampsia is a serious condition that can harm both mother and baby. The test looks at genetic material in the mother's blood to ident…

This study looks at whether a brain wave monitor (BIS) and two blood tests (sFIT/PIGF ratio and adrenomedullin) can more accurately grade the severity of preeclampsia and eclampsia in pregnant women. Researchers will enroll 48 participants to see if these tools can predict risk b…

This study tests whether screening for gestational diabetes in the first trimester (instead of the usual third trimester) can detect the condition earlier in high-risk pregnancies. Researchers will use a combination of risk factors and blood markers to predict GDM. The goal is to…

This study is testing whether a quick, non-invasive test of blood vessel function can help predict and diagnose preeclampsia and other high blood pressure disorders in pregnancy. Researchers will follow 400 first-time pregnant women, measuring vessel health early in pregnancy and…

This study is testing whether three substances in the blood can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 120 pregnant women between 20 and 36 weeks. The goal is to find a…

This pilot study will enroll 150 pregnant individuals to see if a continuous glucose monitor (CGM) can accurately diagnose gestational diabetes. Participants will wear a small sensor on their arm that measures blood sugar continuously. The results will be compared to the standard…

This study is testing two new ways to predict gestational diabetes and large babies (macrosomia) in pregnant women. Researchers will measure skin autofluorescence and glycated albumin in 800 pregnant women and compare them to the standard HbA1c test. The goal is to see if these m…

This study is testing whether two questionnaires (SCOFF-F and EDE-Q) can accurately detect eating disorders in pregnant women, separating them from normal pregnancy-related eating concerns. Researchers will compare answers from 50 pregnant women with and without diagnosed eating …

This study tests whether lung ultrasound can detect fluid overload in women with severe preeclampsia, a condition that can lead to life-threatening pulmonary edema. Researchers will scan the lungs of 202 pregnant women at three key times: upon admission, right after delivery, and…

This study is testing a new test called the Enlighten Device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and follow them for three months after delivery…

This study looks at whether doing a diabetes test right after giving birth (instead of waiting 4-12 weeks) helps more women get screened for type 2 diabetes after having gestational diabetes. It also asks women about their views on heart-health programs after pregnancy. About 104…

This study compares a glucose tolerance test given right after childbirth to the standard test given 6 weeks later in women with gestational diabetes. Researchers want to see if the early test is accurate and if it helps more women get tested. About 300 women will participate.

This pilot study is testing whether eating fermented poi every day for four weeks can improve the gut health of pregnant women and lower their risk of developing gestational diabetes. Fifty pregnant women between 10 and 24 weeks will eat one pound of poi daily and receive nutriti…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study compares two different doses of vitamin D3 supplements in pregnant women who have low vitamin D levels. The goal is to see if a higher dose (50,000 IU every two weeks) is better than a lower dose (5,000 IU weekly) at preventing preeclampsia, a serious pregnancy complic…

This study tests whether taking 150 mg of aspirin daily, starting before 20 weeks of pregnancy, can prevent serious problems like preeclampsia, poor fetal growth, placental abruption, preterm birth, and death in pregnant women with chronic high blood pressure. About 500 women wil…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This study tests a fully online program called Yes and Know for teens aged 14-19. The program includes group sessions and digital tools to teach about sexual health, relationships, and life skills. About 1,200 teens will take part, with half receiving the program and half receivi…

This study tests whether taking a daily low-dose aspirin (150 mg) starting early in pregnancy can prevent preterm preeclampsia in first-time mothers who became pregnant through assisted reproductive technology (ART) like IVF. About 1,164 women will be randomly assigned to receive…

This study looks at the safety of two HIV prevention methods (a long-acting shot and daily pills) in pregnant and breastfeeding women in Malawi. About 621 women who are already using or start these drugs during pregnancy will be followed along with their infants. The goal is to s…

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) in pregnant women at risk. Over 10,000 participants will be assigned to one of the two doses early in pregnancy. The goa…

This study tests a new method called U-CaVIT, which uses a balloon placed in the uterus to prevent severe bleeding after a C-section in women at high risk. About 70 participants will either get standard care or standard care plus the balloon. The goal is to see if the balloon red…

This study tests whether regularly warming the legs with a portable sauna blanket can improve blood vessel health and lower the risk of high blood pressure disorders in pregnant women with obesity. About 118 women will use the blanket at home for 16 weeks, starting early in pregn…

This study tests whether taking 162 mg of aspirin daily (two baby aspirins) is better than the usual 81 mg for preventing another early birth. It includes 1,800 pregnant women who have previously delivered before 35 weeks. Participants start the medicine between 10 and 15 weeks o…

This study aims to develop a better system to support breastfeeding for women who had gestational diabetes, with the goal of preventing type 2 diabetes later. Researchers will work with patients, healthcare providers, and hospital leaders to design a practical strategy. Only 10 p…

This study looks at whether natural salicylates found in foods like fruits and vegetables can help prevent preeclampsia, a dangerous pregnancy condition. Researchers will track the diets of 500 pregnant women and measure salicylate levels in their blood and urine. The goal is to …

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This study is testing whether a simple screening test in early pregnancy (around 11-14 weeks) can predict and help prevent preeclampsia, a dangerous condition involving high blood pressure. The trial will involve 14,500 pregnant women and aims to reduce severe complications like …

This study aims to see if a new screening program during the first trimester can better identify pregnant women at risk for preeclampsia—a condition causing high blood pressure that can harm both mother and baby. Up to 80,000 women in Denmark will take part. Those found to be hig…

This study tests whether extra lifestyle coaching plus medically tailored meals can help prevent type 2 diabetes in mothers who had gestational diabetes. Nearly 1,000 pregnant or recently postpartum women from home visiting programs will be randomly assigned to receive either enh…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. Participants will either join online group classes for 12 months or receive sta…

This study is testing whether following a Mediterranean diet during pregnancy can reduce the chance of children developing allergies by age 2. Researchers are enrolling 276 healthy pregnant women (ages 20-35) who are at risk of having a baby with allergies. Participants receive p…

This study looks at whether a structured ultrasound program (OxGRIP) can help detect babies that are not growing well in the womb, which is a major risk factor for stillbirth. The program adds a routine scan at 36 weeks and extra scans for at-risk women. Researchers will compare …

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study tests whether starting a higher dose of aspirin very early in pregnancy (before 7 weeks) can lower the risk of preeclampsia and pregnancy loss in women with risk factors. About 1,150 pregnant women will take either 162 mg of aspirin daily or a placebo followed by stand…

This study tests whether taking vitamin D supplements can prevent preeclampsia from returning in pregnant women who had it before. About 146 women will be randomly assigned to take either vitamin D or a placebo pill until 36 weeks of pregnancy. Researchers will track blood pressu…

This study tests whether limiting eating to a 10-hour window each day can lower the chance of developing gestational diabetes in pregnant women at high risk. Researchers will compare this approach to usual eating habits over 3 months in 240 women. The goal is to see if this simpl…

This study tests whether taking vitamin D and prebiotics (inulin) during early pregnancy can help control blood sugar in women at high risk for gestational diabetes. 500 pregnant women will receive supplements or placebos from 6-15 weeks of pregnancy. The goal is to see if these …

This study will test whether giving women with gestational diabetes a home ultrasound device, guided remotely by a doctor, improves their satisfaction and health outcomes compared to standard care. About 90 participants will use the device for fetal checks from home. The goal is …

This study is testing a mobile health app called Moms@Home to help pregnant women with high blood pressure monitor their readings at home. About 100 women with gestational or chronic hypertension will use the app and share their home blood pressure data. The goal is to see if the…

This study compares virtual reality (VR) relaxation with face-to-face relaxation for pregnant women hospitalized with preeclampsia, a condition causing high blood pressure. Researchers will measure anxiety, comfort, heart rate, and baby's well-being in 96 participants. The goal i…

This study tests a program called Care4mommies that teaches self-compassion skills to pregnant women. The goal is to see if it helps mothers feel better emotionally and bond more strongly with their babies after birth. About 96 pregnant women will take part, and researchers will …

This study tests whether a simple handgrip exercise can safely lower blood pressure and improve thinking skills in pregnant women with and without chronic hypertension. Thirty pregnant women will either perform short handgrip squeezes or rest quietly, and researchers will measure…

This pilot study is testing a smartphone app called MyGlucoCare that provides personalized education, clinician support, and a peer group for women with gestational diabetes. About 30 pregnant women will use the app for 8 to 12 weeks. Researchers want to see if the app is practic…

This study tests whether natural cervical ripening methods can help labor start on its own in pregnant women with diet-controlled gestational diabetes. About 74 participants will try these methods starting at 37 weeks to see if they can avoid a medically induced labor. The goal i…

This pilot study tests whether participating in the Lullaby Project—where pregnant women with epilepsy work with musicians to create a personal lullaby—can improve their quality of life and reduce anxiety, depression, and stress. Thirty first-time pregnant women with epilepsy wil…

This study tests whether using a health app for follow-up after a gynecological emergency is as good as or better than traditional in-person visits. About 200 women aged 18-60 with conditions like ectopic pregnancy or miscarriage will either use the app to log symptoms and get ca…

This pilot study is testing how exenatide, a drug already used for type 2 diabetes, works in pregnant women with gestational diabetes. Researchers will measure how the body processes the drug and how well it controls blood sugar after a meal. The study involves 13 pregnant women …

This study tests whether eating protein and fat (scrambled eggs) before carbohydrates (toast) can reduce blood sugar spikes in women with gestational diabetes. Thirty-five pregnant women will eat the same breakfast in two different orders on separate days, acting as their own con…

This study tests whether sexual counseling during pregnancy can improve sexual function, marital adjustment, and emotional health. About 70 pregnant women will receive either counseling or standard care. Researchers will measure changes before delivery and three months after birt…

This study tests whether 8 weeks of diaphragmatic breathing or pelvic stabilization exercises, done at home via video calls, can reduce pain and disability in 60 postpartum women with pregnancy-related pelvic girdle pain. Participants will also receive pelvic anatomy education. T…

This study tests whether a non-invasive physiotherapy technique that stimulates the vagus nerve can help lower blood pressure in pregnant women with preeclampsia. About 210 women will receive either standard blood pressure medication alone or medication plus this gentle therapy. …

This study tests whether a daily breathing exercise called alternate nostril breathing can reduce nausea and vomiting in early pregnancy. One hundred pregnant individuals in their first trimester will either practice the breathing technique three times a day for a week or receive…

This pilot study tests whether a specific sequence of maternal position changes (a 'circuit') can improve outcomes for women whose labor is progressing slowly. 82 participants with prolonged labor will be randomly assigned to either the circuit or standard care. The study will me…

This pilot study tests whether using a pelvic wand for perineal massage in late pregnancy and during labor can help women feel more in control and reduce pelvic injuries. Researchers will enroll 140 pregnant women at Beth Israel Deaconess Medical Center. Participants will either …

This study tests a mobile app called BumptUp to see if it helps pregnant and postpartum women in rural areas become more physically active. About 176 women will either use the app or receive an educational brochure. Researchers will track activity levels, weight, diet, blood pres…

This study looks at whether coloring mandalas can lower stress, anxiety, and pain in women who have a missed abortion (a pregnancy loss before 10 weeks). About 126 women will be randomly assigned to either color mandalas or receive standard care. Researchers will measure changes …

This study tests whether applying a sterile lubricant gel during the pushing phase of labor can shorten delivery time and protect the mother's perineum. Researchers will compare 160 women who receive the gel to those who do not. The goal is to see if reducing friction helps the b…

This study looks at whether using a peanut-shaped birthing ball during scheduled position changes can help first-time mothers who have epidural pain relief have a shorter and safer labor. About 110 low-risk women in Qatar will be randomly assigned to either use the peanut ball or…

This study tests whether giving progesterone (a hormone) after intrauterine insemination (IUI) with mild ovarian stimulation increases the chance of a live birth. About 1,000 couples with unexplained infertility will take part. The goal is to see if this simple support can improv…

This study compares two pain relief methods—propofol sedation and spinal analgesia with bupivacaine—during a procedure to turn breech babies (external cephalic version). The goal is to see which method leads to more successful turns and fewer complications. 270 pregnant women wit…

This study tests whether taking calcium carbonate (a common calcium supplement) every 4 hours during labor can safely improve contractions and reduce the need for high doses of synthetic oxytocin. The trial will enroll 60 first-time mothers who are being induced or need help with…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This pilot study is testing a specially designed exercise program for high-risk pregnant women who are hospitalized on bed rest. The exercises are adapted to be done while lying in bed, focusing on strength and resistance. Researchers want to see if this program can improve physi…

This study follows up to 20 people of any age who took the drug odevixibat while pregnant or breastfeeding. Researchers will collect routine medical data to see if the drug is linked to birth defects, pregnancy complications, or harm to the baby. No extra tests or visits are requ…

This study follows 600 Indigenous families in Manitoba to understand how maternal health, genetics, and early-life environment contribute to obesity and type 2 diabetes in children. Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes are enrolled, and their …

This study follows thousands of very low birth-weight and premature infants to track their development over time. Researchers collect data on pregnancy, birth, and early childhood outcomes to identify factors that influence brain and body development. No treatments are tested—thi…

This study follows pregnant women who have taken Epidiolex (a cannabidiol medicine for seizures) to see if it affects pregnancy outcomes or the baby's health up to 12 months after birth. Researchers will track complications like birth defects, miscarriage, and preterm delivery. T…

This study looks at whether giving moms extra education about breastfeeding before they give birth helps them breastfeed exclusively for the first 6 weeks. About 196 first-time or less-experienced mothers will take part. Researchers will compare breastfeeding rates between those …

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This observational study looks at 420 pregnant women to see if physical fitness tests (like hand grip and chair stands) and emotional surveys (about fear and confidence) can predict whether a birth will be natural or require medical help. It also checks if these factors affect br…

This study tests whether giving gynecologic cancer patients a list of questions to ask their doctor improves their confidence, reduces distress, and builds trust. About 70 adults with newly diagnosed or suspected gynecologic cancer will either receive the question list or usual c…

This study looks at whether simulation training for doctors, nurses, and midwives can reduce the number of cervical exams women receive during labor and make exam results more consistent. Over 1,100 healthcare providers and patients will take part. The goal is to improve care wit…

This study explores the real-life experiences of people who had Lyme disease during or before pregnancy and are now raising children. Participants fill out surveys about their health, mental well-being, and child development, then take part in an interview to share their personal…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…

This study looks at why some babies grow poorly early in pregnancy for no known reason. Researchers will measure a key hormone (progesterone) in the mother's blood and examine a protective protein in the placenta after birth. By comparing 58 pregnancies, they hope to uncover clue…

This study tracks pregnant women with narcolepsy who take pitolisant (Wakix) or other narcolepsy medications, as well as pregnant women without narcolepsy who take pitolisant. Researchers compare pregnancy outcomes, including birth defects, to see if the drug poses risks. The goa…

This study checks if a French version of the MEPS/MEPI elbow score works well for children aged 4 to 17. It includes kids with and without elbow injuries to see if the score accurately measures elbow pain and function. The goal is to make sure doctors can use this tool reliably i…

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) for Black women and birthing persons. Researchers will work with community organizations and advisory boards to identify barriers and facilitators to implementation. The goal is to make the program …

This study follows 200 babies diagnosed with poor growth in the womb (IUGR) using advanced ultrasound and MRI scans. Researchers want to understand how the baby's brain, heart, and placenta change over time. The goal is to link these changes to the child's development after birth…

This study aims to better understand pre-eclampsia and intrauterine growth restriction (IUGR), serious pregnancy complications affecting about 9% of pregnancies. Researchers will collect placenta, blood, and urine samples from 500 pregnant women—both with and without these condit…

This study looks at whether drinking 200 ml of water two hours before a planned C-section changes stomach volume differently in pregnant women with diabetes compared to those without. Researchers will use ultrasound to measure stomach contents before and after drinking. The goal …

This study is testing whether a mobile phone app can help pregnant women at high risk for preeclampsia in Karachi, Pakistan, monitor their blood pressure and symptoms at home. Fifty women will use the app to send daily readings to their healthcare team, who can then respond if ne…

This study follows 140 pregnant women who conceived while still breastfeeding. Researchers want to see if breastfeeding lowers the chance of developing gestational diabetes in the new pregnancy. They will track blood sugar levels and baby growth to find out.

This study tests a smartphone app designed to help African American and Spanish-speaking patients recognize warning signs of pregnancy-related death. Participants choose symptoms they are having and get advice on when to call a doctor or go to the emergency room. The goal is to s…

This study looks at whether treating gestational diabetes early (before 24 weeks) is better than waiting until the standard 24-28 week screening. About 2,010 pregnant women with mild early high blood sugar will be randomly assigned to either start intensive treatment right away o…

This study follows 27 pregnant women living at high altitude in Bolivia and compares them to women at sea level. Researchers will use heart ultrasounds and blood tests to see how the body adapts to low oxygen levels during pregnancy. The goal is to better understand why some wome…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study looks at how taking 81mg of aspirin twice a day affects blood platelets in pregnant women who are at high risk for preeclampsia. Researchers will collect blood samples about 4 weeks after starting aspirin to measure platelet function. The goal is to understand the best…

This study looks at whether pregnant women who eat 10-14 eggs per week have babies with better brain development compared to those who just follow a healthy prenatal diet. Researchers will measure fetal heart rate and later do brain scans on the infants. The goal is to see if boo…

This study looks at how growth hormone affects beta-cells, which make insulin to control blood sugar, in women who had gestational diabetes. Researchers will compare women with and without a history of gestational diabetes to better understand risk factors. The goal is to learn m…

This study tests an iPad app called Periviable GOALS that helps parents facing a very early preterm birth (22-25 weeks) understand their options and clarify their values. The app includes videos and outcome information designed for people with varying literacy levels. Researchers…

This study looks at how pregnant women sleep, focusing on the positions they spend the most time in and how often they snore. About 500 women who are at least 28 weeks pregnant will use a sleep monitor at home. The goal is to learn more about sleep patterns during pregnancy and s…

This study is testing whether a new wireless skin sensor system can safely and accurately monitor the heart rate, breathing, oxygen levels, and temperature of healthy newborns right after birth. 600 babies will wear both the wireless sensors and standard wired monitors for the fi…

This study is creating a registry and biorepository for people who have had a suspected amniotic fluid embolism (AFE), a rare and serious pregnancy complication. Researchers will collect medical information and biological samples from up to 400 participants, including mothers, th…

This study compares two types of uterine incisions (high vs low) during a first cesarean section to see which leads to fewer scar defects. 168 pregnant women having their first C-section will be randomly assigned to one of four groups, combining incision type with a stitching tec…

This study examines how cells in the placenta manage waste and self-destruction in women with pregnancy complications like pre-eclampsia and intrauterine growth restriction. Researchers will take blood and urine samples from 50 pregnant women throughout their pregnancy and at del…

This study looks at how anti-seizure medications are processed in the bodies of pregnant women with epilepsy. Researchers will measure drug levels in the blood and urine to understand how much reaches the unborn baby and nursing infant. The goal is to help doctors choose safer do…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study tests whether sending automatic WhatsApp reminders helps more women with gestational diabetes attend their postpartum glucose test. It also compares a newer one-hour blood sugar measurement to the standard two-hour test to see which catches prediabetes and diabetes ear…

This study is collecting blood samples from 100 pregnant women with and without preeclampsia to measure key proteins involved in the condition. The goal is to better understand the angiogenic imbalance that causes symptoms and to develop a device that filters out harmful proteins…

This study from the University of Oxford looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel disease later in life. Researchers will follow 200 women who gave birth 10 to 25 years ago, using heart scans, exercise tests…

This study looks at how lung ultrasound can help find lung issues early in women who are critically ill due to pregnancy complications or gynecologic cancer. Researchers will check for different lung ultrasound patterns and see if they relate to patient outcomes like death or nee…

This study looks at whether digital devices like smartwatches and blood pressure cuffs can help detect high blood pressure and related pregnancy problems in refugee women. About 75 pregnant refugee women will use these tools at home and complete surveys. The goal is to see if thi…

This study is testing a unified first trimester screening approach to predict serious pregnancy complications like preeclampsia, fetal growth restriction, and birth defects. Researchers will enroll 2,000 pregnant women in the Czech Republic to see if combining standard tests can …

This study looks at how different arm positions change blood pressure readings in pregnant women. About 300 pregnant women will have their blood pressure taken with their arm in three positions: supported at heart level, on the lap, and hanging at the side. The goal is to find ou…

This study aims to find early signs of heart failure in women who had preeclampsia, a pregnancy complication involving high blood pressure. Researchers will use exercise stress tests and heart imaging to compare 250 women with a history of preeclampsia to 250 women with normal pr…

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This study aims to find early molecular signs of preeclampsia, a serious pregnancy condition, by examining tissue from the womb (maternal-fetal interface) collected between weeks 9 and 15 of pregnancy. Researchers will compare samples from women who later develop preeclampsia wit…

This study follows 800 pregnant women—some healthy, some with obesity or diabetes—to understand how these conditions affect both mother and baby during pregnancy and after birth. Researchers will track body composition, blood sugar, blood pressure, and other health markers throug…

This study follows 400 pregnant women diagnosed with gestational diabetes to understand how it affects their health and their baby's health. Researchers will track things like blood sugar, blood pressure, and body fat during pregnancy and after birth. The goal is to learn more ab…

This study follows 462 women pregnant after egg donation or standard IVF to learn why pre-eclampsia is more common in egg donation pregnancies. Participants give blood samples and have regular check-ups throughout pregnancy. The goal is to find early warning signs and improve car…

This study is following 250 pregnant women diagnosed with preeclampsia, a serious condition involving high blood pressure and organ problems. Researchers will collect health data and samples from mothers and babies during pregnancy, at birth, and a few months after. The goal is t…

This study is developing a smart computer program that can separate a baby's heartbeat from the mother's using sensors placed on the belly. Researchers will collect recordings from 350 pregnant women in their second or third trimester. The goal is to make fetal heart monitoring f…

This study looks at whether routine blood sugar tests (like fasting glucose and HbA1c) can predict gestational diabetes in pregnant women who have had bariatric surgery and cannot tolerate the standard sugary drink test. Researchers will follow 84 women throughout pregnancy to se…

This study uses a special contrast dye (SonoVue) during ultrasound to look at blood flow in the placenta of pregnant women with fetal growth restriction. The goal is to better understand how the placenta works when the baby is not growing well. Thirty women who have already decid…

This study looks at how three common blood pressure medications (ephedrine, phenylepinephrine, and norepinephrine) affect the ability of the uterus to contract after a C-section in women with type 2 or gestational diabetes. Researchers will take small tissue samples from the uter…

This study looks at how the metabolism of both parents during pregnancy may change the baby's epigenetics—chemical marks on DNA—in gestational diabetes. Researchers will test 80 pregnant women and their partners, analyzing blood and fetal cell-free DNA. The goal is to better unde…

This study aims to map gene activity in the placenta at two key points in pregnancy: the first trimester and at childbirth. Researchers will analyze small tissue samples from 100 pregnant women to understand how placental cells change over time. The goal is to learn more about no…

This study looks at whether levels of key minerals like iron, calcium, and zinc in pregnant women are linked to how their babies grow. Researchers will measure these minerals in blood, hair, and amniotic fluid during each trimester. The goal is to create better nutrition advice f…

This study looks at how women with HIV in the United States decide to feed their babies, whether by breastfeeding or formula. Researchers will interview mothers and track their choices and health outcomes. The goal is to fill gaps in knowledge and create a national registry to be…

This study follows 600 pregnant women with gestational diabetes to see how depression and diabetes affect each other during pregnancy and after birth. Some participants will receive short health education videos about diet, exercise, and support. The goal is to understand the con…

This study aims to find genetic factors that may cause repeated miscarriages or unexplained fetal deaths. Researchers will collect biological samples from 200 couples who have experienced at least three early miscarriages or a fetal death in the second or third trimester. By comp…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track health outcomes for both mothers and babies, such as relapse and withdrawal symptoms. The goal is to find better ways to predict and prevent complic…

This study aims to learn more about abnormal development of the face, head, and neck by comparing people with these conditions to their family members and healthy volunteers. Researchers will collect medical history, perform exams, take 3D images, and analyze genetic samples from…

This 10-year observational registry will follow up to 10 women with Fabry disease who received pegunigalsidase alfa (Elfabrio) around the time of pregnancy or while breastfeeding, along with their infants. Researchers will track pregnancy outcomes, birth defects, and infant healt…

This study looks at a special antenatal clinic called the Rainbow Clinic, designed for women who have previously experienced stillbirth or neonatal death. Researchers will track pregnancy outcomes and measure anxiety and depression in 500 women attending these clinics across the …

This study is a large registry that collects information on very low birth weight infants (weighing 401-1000 grams or born before 29 weeks) at multiple hospitals. Researchers track the babies' health, treatments, and outcomes to find patterns and improve future care. No experimen…

This study is for pregnant women whose babies are not growing well due to a problem with the placenta. Researchers will use artificial intelligence and special ultrasound scans to better predict which babies are at risk for complications. The goal is to improve care and outcomes …

This study is a patient registry for women diagnosed with Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy. Researchers will collect data from 3,000 participants to identify possible causes, evaluate care trends, and review short- and long-term outcomes…

This study looks at the best way to manage women who have a molar pregnancy (a rare abnormal pregnancy) and also have a lung nodule found on a CT scan. Researchers want to see if starting chemotherapy right away is better than waiting to see if the nodule goes away on its own. Ab…

This study is collecting information on pregnancy and malaria in 9,500 women aged 15-49 in Kalifabougou, Mali. Researchers will track pregnancies, malaria cases, and pregnancy outcomes like preterm birth and anemia. The goal is to better understand these health issues in the comm…

This study looks at how often the diaphragm — the main muscle used for breathing — becomes weak after a C-section in women with severe preeclampsia. Researchers will use ultrasound to measure diaphragm movement before and 24 hours after surgery in 52 women. The goal is to find ou…

This study looks at how tiny particles released by the placenta, called extracellular vesicles, affect pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect samples from 360 pregnant and non-pregnant women to understand these particles bett…

This study is collecting blood, amniotic fluid, and placenta samples from 100 pregnant women, including those with pregnancy-induced hypertension and those who have had a miscarriage. Researchers will test these samples to look for differences in immune cells and other markers. T…

This study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…

This pilot study is testing whether wearing a continuous glucose monitor (CGM) for just 24 hours after giving birth can help predict a woman's long-term risk of developing type 2 diabetes. The study involves 50 women who had gestational diabetes and will wear the CGM immediately …

This study looks at pregnant women whose routine blood tests for the baby's DNA came back unusual or unclear. Researchers want to find out if these results can signal cancer in the mother. Participants will have imaging, lab tests, and surveys, and may be followed for up to 5 yea…

This study aims to find factors that can be changed to prevent stillbirths between 20 and 28 weeks of pregnancy. Researchers will compare 316 mothers who experienced an early stillbirth with 632 mothers with healthy pregnancies, using questionnaires about sleep, diet, and care. T…

This observational study compares airway measurements using ultrasound among three groups: nonpregnant women, pregnant women with normal blood pressure, and pregnant women with preeclampsia. Researchers will measure distances from the skin to key airway structures and assess lary…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study follows 500 mother-child pairs where the mother has a severe hemophilia A gene. It aims to understand bleeding risks during pregnancy and childbirth for mothers, and how children develop antibodies to factor VIII treatment. By observing families over time, researchers …

This study looks at whether avoiding non-nutritive sweeteners (like those in diet sodas) during pregnancy and breastfeeding can lower babies' risk of obesity and improve mothers' blood sugar control. About 324 pregnant women who regularly consume these sweeteners will be split in…

This study tracks 242 pregnant women to measure how their heart rate and blood pressure change from the third month of pregnancy through the postpartum period. Researchers use non-invasive tests like ECG and blood pressure cuffs to understand the body's natural adjustments. The g…

This study looks at why pregnant women living at high altitudes have higher rates of preeclampsia and poor fetal growth. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their …

This study looks at why women who had preeclampsia during pregnancy have higher heart disease risk later in life. Researchers will test a drug called eplerenone on small skin blood vessels in 40 women (some with prior preeclampsia, some without) to see if it improves vessel funct…

This study tests whether a wrist-worn device can help monitor pregnant women with congenital heart disease. Researchers will track heart rhythms and other data from 50 participants to see if the wearable can detect early signs of trouble. The goal is to improve care and reduce th…

This study uses ultrasound to measure muscle, fat, and fluid changes in 121 critically ill pregnant or gynecological patients in the ICU. The goal is to see if these body composition changes are linked to serious outcomes like death, need for a breathing machine, or longer hospit…

This study follows 60 women with neuromyelitis optica spectrum disorder (NMOSD) who received UPLIZNA during pregnancy or within 6 months before conception. Researchers will collect data on pregnancy outcomes, including birth defects, preterm birth, and infant development over 10 …

This study looks at how a woman's past pregnancies may change her immune system's response to breast cancer. Researchers will follow 800 young women with breast cancer to see if pregnancy history affects how long they live without the cancer getting worse. The goal is to better u…

This study tests whether small wearable sensors can accurately track movement and walking patterns in 30 pregnant women during early labor, both with and without a low-dose epidural. The goal is to see if these sensors can help monitor pain relief effectiveness, predict fall risk…

This study is testing a special camera (Mueller polarimetric colposcopy) to see if it can measure changes in the cervix during pregnancy. The goal is to find patterns that could help predict if a baby will be born early (preterm). Researchers will study 683 pregnant women, both w…

This study follows 1,260 women 3 to 6 years after their first pregnancy to see how pregnancy complications like preeclampsia affect heart health. Researchers will check blood pressure, heart function, and artery health, and also look at lifestyle and environment. The goal is to c…

This study looks at whether a continuous glucose monitor (CGM) — a small sensor worn under the skin — is an acceptable and useful tool for checking diabetes risk in women who recently had gestational diabetes. Twenty women will wear the CGM for 10 days at 6-8 weeks after giving b…

This study follows 200 pregnant women who take tildrakizumab for conditions like psoriasis, along with a similar group who don't take the drug. Researchers track pregnancy outcomes and infant health up to one year after birth to check for birth defects or other problems. The goal…

This study collects tissue samples from women with and without preeclampsia during C-sections to examine blood vessel function. Researchers focus on a protein called AT2R, which may play a role in the condition. The goal is to better understand how preeclampsia affects blood vess…

This study tests a new way to classify placenta accreta during surgery, aiming to guide the best surgical approach. Researchers will follow 60 pregnant people at risk, using ultrasound before surgery and a classification system during the operation. The goal is to see if this sys…

This study looks at how long new mothers with high blood pressure should monitor their blood pressure from home after giving birth. Researchers will compare a 2-week program to a 6-week program to see which leads to better health outcomes. About 400 women who have already joined …

This study aims to understand how tiny particles called exosomes, released from the placenta, may cause preeclampsia—a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these pa…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This registry follows 1,500 women with multiple sclerosis (MS) or related conditions through pregnancy and after childbirth. Researchers will track relapses, use of disease-modifying drugs, and outcomes for both mothers and children. The goal is to better understand how MS and it…

This study is testing a simple bedside device called a bioimpedance analyser to measure body water changes in pregnant women. Researchers will compare its readings to standard fluid charts in 900 women, including those having planned C-sections, induced labor, or conditions like …

This observational study follows 100 pregnant women with gestational diabetes to see how sleep quality, anxiety, eating habits, and lifestyle relate to blood sugar control and birth outcomes. Participants complete questionnaires and undergo glucose monitoring either at home or du…

This study looks at pregnancy outcomes in 50 women who had at least one pregnancy before being diagnosed with lupus. Researchers will collect data from medical records and interviews to see how often pregnancy complications occurred before the lupus diagnosis. The goal is to bett…

This study is for pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers want to see how aspirin changes tiny particles from the placenta in the blood. They hope to create a blood test that can better monitor placental health and predic…

This study uses a special MRI technique to compare blood flow and oxygen levels in the placentas of pregnant women with diabetes versus healthy pregnant women. Researchers will enroll 40 participants to see if diabetic placentas have lower blood flow. The goal is to better unders…

This study looks at whether early-onset preeclampsia (a serious pregnancy condition) affects the size of two brain areas in the fetus: the fornix and hippocampus. Researchers will use ultrasound to measure these areas in 84 pregnant women—half with early-onset preeclampsia and ha…

The CONEXUS study is testing a new type of brain imaging called functional ultrasound (fUS) in 76 newborns at high risk for neurodevelopmental disorders. The technique uses sound waves to measure blood flow changes in the brain, similar to a regular ultrasound but more advanced. …

This study is gathering information from 640 pregnant people to build a computer model that can predict placental insufficiency — a condition where the placenta doesn't work well and can lead to stillbirth. Participants will have extra ultrasounds and blood tests during pregnancy…

This study looks at how having gestational diabetes during pregnancy might affect blood flow and blood vessel function in the brain after childbirth. Researchers will use ultrasound to measure brain blood flow in women who had gestational diabetes and compare them to women with h…

This study uses MRI scans to measure how well oxygen moves through the placenta in pregnancies complicated by intrauterine growth restriction (IUGR), where the baby is not growing as expected. Researchers will compare MRI results with placenta tissue after birth and track the bab…

This study looks at why women who had gestational diabetes (diabetes during pregnancy) often have higher heart disease risk years later. Researchers will test how a natural chemical called endothelin-1 affects small blood vessels in 40 women who had a baby within the last 5 years…

This study will analyze health records of over 5,600 pregnant women with atopic dermatitis (eczema) to compare infant outcomes between those who used ruxolitinib cream (Opzelura) and those who used topical corticosteroid creams. Researchers will look at rates of major birth defec…

This study follows about 958 pregnant women with mild to moderate eczema (atopic dermatitis) who use ruxolitinib cream (Opzelura) and compares them to similar women who do not use the cream. Researchers track birth defects and other pregnancy outcomes to see if the cream is linke…

This study tests a two-way SMS system that lets pregnant women in Kenya text community health volunteers about their newborn's health. The goal is to see if this quick communication can reduce deaths in the first month of life. About 3000 women will take part, and the results cou…

This study is testing whether a blood test that measures certain markers (sFlt-1/PlGF) can help doctors decide when to deliver babies in women with mild preeclampsia at term. Instead of automatically inducing labor at 37 weeks, women with normal test results would wait until 39 w…

This study looks at whether a new training program for doctors and a different way of counseling women can increase the number of women who safely have a vaginal birth after having two previous C-sections. Researchers will compare outcomes for about 2,000 women who gave birth in …

This study follows 6,000 pregnant women in rural Pakistan to understand how high temperatures impact pregnancy and birth outcomes. Researchers will track heat exposure, collect blood and urine samples, and monitor mothers and babies for up to a year after birth. The goal is to id…

This study looks at whether a blood gas measurement called base excess differs between pregnant women with severe preeclampsia and those with normal blood pressure. Researchers will test 100 women before delivery to see if abnormal base excess levels are linked to more severe dis…

This study will follow 1000 pregnant women to find what raises the risk of gestational diabetes and create a tool to predict it early. Then, some women will try a personalized health plan (GLOW plan) to see if it improves blood sugar control. The goal is to reduce short- and long…

This study interviews women who gave birth in French-speaking Belgium within the last year to understand why they chose a particular place of birth and how their childbirth experience was. Researchers also talk to birth companions like doulas and healthcare professionals. The goa…

This study follows 825 pregnant women who need blood thinners for blood clots, observing how these medications are managed around labor and delivery. Researchers aim to see how different strategies affect bleeding risks. The goal is to find safer ways to handle blood thinners dur…

This observational study at Turku University Hospital will use ultrasound radiomics to compare fetal liver texture between 60 pregnant women with type 1 diabetes and healthy controls. The goal is to see if this noninvasive method can detect signs of fetal hyperinsulinemia (high i…

This study follows 2,800 pregnant women and their children in Weifang, China, from early pregnancy until the child turns 18. Researchers collect data on diet, lifestyle, and environment, along with blood, urine, and other samples. The goal is to understand how factors before and …

This study looks at whether women with gestational diabetes (GDM) experience muscle loss, known as sarcopenia, and how this might affect pregnancy outcomes and thinking skills. Researchers will test 200 pregnant women using muscle strength and function tests, along with standard …

This study follows 100 pregnant women with gestational diabetes to understand how their daily blood sugar patterns relate to their baby's growth. Participants wear a continuous glucose monitor for 14 days and have routine checkups. The goal is to learn which blood sugar patterns …

This pilot study is testing whether it's practical to run a larger trial that compares inducing labor at 38 weeks versus waiting for natural labor in people with gestational diabetes. About 260 participants will be randomly assigned to either early induction or expectant manageme…

This observational study is looking at the safety of the heart medication mavacamten when taken during pregnancy or while breastfeeding. Researchers will follow about 20 people who have taken at least one dose of mavacamten during pregnancy or breastfeeding, tracking outcomes for…

This study looks at why low-dose aspirin sometimes fails to prevent preeclampsia, a serious pregnancy complication. Researchers will study genetic and platelet factors in 130 women who had preeclampsia before and took aspirin in a later pregnancy. The goal is to understand why so…

This study uses MRI to measure pancreas size in pregnant women and their babies, since smaller pancreases are linked to diabetes. Researchers will follow 87 women from early pregnancy to one year after birth. The goal is to see how pancreas changes relate to diabetes, which could…

This study is testing whether a program originally designed for clinics can work in community settings to help pregnant women with a BMI over 30 stay active and healthy. Researchers will enroll 60 expecting mothers to see if the program is easy to use and follow. The goal is to l…

This study follows 1,489 women diagnosed with hydatidiform mole (molar pregnancy) across multiple hospitals in China. Researchers will track how often the condition becomes cancerous and look for ways to predict and prevent that. The goal is to create a nationwide system for bett…

This study tests whether pregnant women with complications like pre-eclampsia or fetal growth restriction can use a remote device at home to monitor their baby's heart rate. Sixty participants between 32 and 37 weeks of pregnancy will try the device daily. Researchers will check …

This study looks at how pregnant and non-pregnant people recover after being in the intensive care unit (ICU) for severe COVID-19. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after leaving the ICU. The goal is to understand the lon…

This study aims to develop a non-invasive blood test that analyzes fetal DNA found in the mother's blood to determine paternity. It is designed for sexual assault victims who become pregnant and need to know the father's identity for legal reasons. The test uses a technique calle…

This long-term study follows 24,000 mothers and their children born at Boston Medical Center to understand how early-life exposures—like pregnancy complications and birth outcomes—affect health later in life. Researchers will track conditions such as asthma, obesity, allergies, a…

This study tests whether adjusting room light during labor can improve uterine contractions and reduce the need for C-sections. Researchers will monitor 100 pregnant women, using different light settings (bright, dim, or red light) to see how it affects contractions and melatonin…

This study looks at whether continuous glucose monitors (CGMs) worn during late pregnancy and for two weeks after birth can predict which women with gestational diabetes will have abnormal blood sugar after delivery. Currently, only a small percentage of women complete the standa…

This study looks at whether tiny particles from blood vessels, found in urine, can help predict which pregnant women with high blood pressure will develop a dangerous condition called pre-eclampsia. Researchers will measure these particles in 110 pregnant women at two points duri…

This study looks at how pregnant women at risk for preeclampsia process aspirin and how that relates to signs of metabolic problems. Researchers will measure aspirin byproducts in blood and urine, along with other health markers, in 50 women. The goal is to better understand why …

This study will follow 4,000 pregnant women with high blood sugar (gestational diabetes or pre-existing diabetes) to create better standards for diagnosis, treatment, and follow-up. Researchers will track health problems in mothers and babies, like preeclampsia or preterm birth, …

This study collects amniotic fluid from 275 pregnant women delivering at various stages, including extremely preterm. Researchers will analyze the fluid's microbes and chemicals, and link them to the baby's gut bacteria and health outcomes like necrotizing enterocolitis (NEC) and…

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers will measure blood vessel stiffness and collect blood samples for a biobank. The goal is to better understand long-term heart and kidney health after these conditio…