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Could a common pill protect new Moms' hearts after complicated pregnancies?

NCT ID NCT07041281

Recruiting now Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether spironolactone, a blood pressure pill, can help women who had high blood pressure during pregnancy avoid long-term heart issues. About 200 women with overweight and recent hypertensive pregnancy will take the drug or a placebo daily for 12 weeks after delivery. Researchers will check blood pressure and heart structure nine months later to see if the drug makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
spironolactone
What this could lead to
If it works, this could point toward a simple daily pill to help women with past hypertensive pregnancy avoid long-term high blood pressure and heart problems.
What could go wrong
This is a small, early-phase trial with only 204 participants, so results may not apply to everyone. Spironolactone can cause side effects like high potassium or kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertension, pregnancy-induced hypertensive disorder preeclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GESTATIONAL HYPERTENSION PREECLAMPSIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Pittsburgh Magee-Womens Hospital

    NOT_YET_RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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