PREECLAMPSIA

This study tests a decision aid—a tool that provides information and goal-setting exercises—to help women who had high blood pressure during pregnancy take steps to protect their heart health after childbirth. The goal is to improve engagement in preventive care like blood pressu…

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metfo…

This early-stage trial tests a single injection of CBP-4888 in 60 pregnant women hospitalized with preterm preeclampsia, a serious condition involving high blood pressure and organ stress. The goal is to find a safe dose and see if the drug can lower a harmful protein called sFlt…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm, skin, and placenta to see if MitoQ helps restore normal function and pr…

This Phase 2 trial tests ravulizumab (Ultomiris) in 14 pregnant individuals with severe preeclampsia or HELLP syndrome before 34 weeks of pregnancy. The drug aims to block part of the immune system that may drive these dangerous conditions. Researchers will measure blood markers …

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study tests whether spironolactone, a blood pressure pill, can help women who had high blood pressure during pregnancy avoid long-term heart issues. About 200 women with overweight and recent hypertensive pregnancy will take the drug or a placebo daily for 12 weeks after del…

Women who had preeclampsia are four times more likely to develop heart disease later in life, possibly due to lasting blood vessel damage. This early-phase trial tests whether taking low-dose aspirin (162 mg daily) can improve blood vessel function in 40 women who had preeclampsi…

The ACHIEVE trial is testing whether giving pregnant women with preeclampsia or high blood pressure medication to keep their blood pressure below 140/90 mmHg can safely prolong their pregnancy. The study will enroll 132 women between 23 and 35 weeks of pregnancy who have mild for…

This study tests whether taking atorvastatin (a statin) for 3 months after childbirth can reduce the long-term risk of heart disease in women who had high blood pressure disorders during pregnancy. 76 postpartum women will receive either atorvastatin or a placebo, and their cardi…

This study tests whether tiny particles from stem cells, called exosomes, can repair blood vessel damage in women who had preeclampsia during pregnancy. Preeclampsia raises the risk of heart disease later in life, and current treatments don't fully heal the blood vessels. The tri…

This study is testing whether a quick, non-invasive test of blood vessel function can help predict and diagnose preeclampsia and other high blood pressure disorders in pregnancy. Researchers will follow 400 first-time pregnant women, measuring vessel health early in pregnancy and…

This study is testing whether three substances in the blood can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 120 pregnant women between 20 and 36 weeks. The goal is to find a…

This study tests whether lung ultrasound can detect fluid overload in women with severe preeclampsia, a condition that can lead to life-threatening pulmonary edema. Researchers will scan the lungs of 202 pregnant women at three key times: upon admission, right after delivery, and…

This study compares two different doses of vitamin D3 supplements in pregnant women who have low vitamin D levels. The goal is to see if a higher dose (50,000 IU every two weeks) is better than a lower dose (5,000 IU weekly) at preventing preeclampsia, a serious pregnancy complic…

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) in pregnant women at risk. Over 10,000 participants will be assigned to one of the two doses early in pregnancy. The goa…

This study looks at whether natural salicylates found in foods like fruits and vegetables can help prevent preeclampsia, a dangerous pregnancy condition. Researchers will track the diets of 500 pregnant women and measure salicylate levels in their blood and urine. The goal is to …

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study tests whether a non-invasive physiotherapy technique that stimulates the vagus nerve can help lower blood pressure in pregnant women with preeclampsia. About 210 women will receive either standard blood pressure medication alone or medication plus this gentle therapy. …

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This study is testing whether a mobile phone app can help pregnant women at high risk for preeclampsia in Karachi, Pakistan, monitor their blood pressure and symptoms at home. Fifty women will use the app to send daily readings to their healthcare team, who can then respond if ne…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study is collecting blood samples from 100 pregnant women with and without preeclampsia to measure key proteins involved in the condition. The goal is to better understand the angiogenic imbalance that causes symptoms and to develop a device that filters out harmful proteins…

This study aims to find early signs of heart failure in women who had preeclampsia, a pregnancy complication involving high blood pressure. Researchers will use exercise stress tests and heart imaging to compare 250 women with a history of preeclampsia to 250 women with normal pr…

This study aims to find early molecular signs of preeclampsia, a serious pregnancy condition, by examining tissue from the womb (maternal-fetal interface) collected between weeks 9 and 15 of pregnancy. Researchers will compare samples from women who later develop preeclampsia wit…

This study looks at why pregnant women living at high altitudes have higher rates of preeclampsia and poor fetal growth. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their …

This study looks at why women who had preeclampsia during pregnancy have higher heart disease risk later in life. Researchers will test a drug called eplerenone on small skin blood vessels in 40 women (some with prior preeclampsia, some without) to see if it improves vessel funct…

This study aims to understand how tiny particles called exosomes, released from the placenta, may cause preeclampsia—a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these pa…

This study is for pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers want to see how aspirin changes tiny particles from the placenta in the blood. They hope to create a blood test that can better monitor placental health and predic…

This study is testing whether a blood test that measures certain markers (sFlt-1/PlGF) can help doctors decide when to deliver babies in women with mild preeclampsia at term. Instead of automatically inducing labor at 37 weeks, women with normal test results would wait until 39 w…

This study looks at whether a blood gas measurement called base excess differs between pregnant women with severe preeclampsia and those with normal blood pressure. Researchers will test 100 women before delivery to see if abnormal base excess levels are linked to more severe dis…

This study looks at why low-dose aspirin sometimes fails to prevent preeclampsia, a serious pregnancy complication. Researchers will study genetic and platelet factors in 130 women who had preeclampsia before and took aspirin in a later pregnancy. The goal is to understand why so…

This study looks at how pregnant women at risk for preeclampsia process aspirin and how that relates to signs of metabolic problems. Researchers will measure aspirin byproducts in blood and urine, along with other health markers, in 50 women. The goal is to better understand why …

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers will measure blood vessel stiffness and collect blood samples for a biobank. The goal is to better understand long-term heart and kidney health after these conditio…