PREECLAMPSIA

This study is testing if a common cholesterol-lowering drug (atorvastatin) can reduce the long-term risk of heart disease in people who developed high blood pressure during pregnancy. After they stop breastfeeding, 76 participants will take either the drug or a placebo pill for t…

This study is testing whether using a specific blood test can help doctors decide when to deliver babies for women with a mild form of preeclampsia. The goal is to safely delay delivery for some women, allowing their babies more time to develop, without increasing risks to the mo…

This study is testing a new therapy to see if it can help repair blood vessel damage in women who recently had preeclampsia, a serious pregnancy complication. The treatment uses tiny healing particles called exosomes, which come from stem cells. Researchers will give the treatmen…

This early-stage study is testing a new injection called CBP-4888 in pregnant women hospitalized with preterm preeclampsia, a serious blood pressure condition. The main goal is to find a safe and tolerable dose and to understand how the drug moves through the body. Participants w…

This study is testing whether carefully lowering blood pressure in pregnant women with preeclampsia or gestational hypertension can safely extend the pregnancy. Researchers want to see if keeping blood pressure below 140/90 mmHg allows babies more time to develop before delivery.…

This study is testing if adding a specially trained 'heart health doula' to standard care helps new mothers recover from pregnancy-related high blood pressure. Researchers will compare two groups: one gets standard home blood pressure monitoring, and the other gets that plus week…

This study is testing if a 3-month course of the medication spironolactone, started soon after delivery, can help control blood pressure and improve heart health in women who had high blood pressure during pregnancy and have overweight or obesity. Researchers want to see if this …

This study aims to monitor the long-term heart and kidney health of women who experienced preeclampsia, HELLP syndrome, or kidney disease during pregnancy. It will follow 100 women to better understand their future health risks. The study is observational, meaning it collects hea…

This study is testing whether the medication ravulizumab can help control severe preeclampsia and HELLP syndrome, dangerous blood pressure disorders that can occur during pregnancy. The trial will involve 14 pregnant individuals who develop these conditions before 34 weeks of pre…

This study is testing new ways to predict which pregnant women might develop high blood pressure disorders or preeclampsia, a serious pregnancy complication. Researchers will use simple, non-invasive tests to measure blood vessel health in 400 first-time mothers during their firs…

This study is testing two new types of ultrasound imaging to see if they can better assess the health of the placenta in pregnant women. Researchers will compare 60 women with healthy pregnancies to those whose babies are not growing as expected (fetal growth restriction). The go…

This study aims to find better ways to diagnose and monitor preeclampsia, a serious pregnancy complication involving high blood pressure. Researchers will test three specific substances in the blood of 120 pregnant women to see if they can predict or track the condition more accu…

This study is testing whether a simple, non-invasive lung ultrasound can reliably detect dangerous fluid overload in pregnant women with severe preeclampsia. Researchers will scan the lungs of 202 patients at key times—upon hospital admission, right after delivery, and about a we…

This large study aims to find out if a higher daily dose of aspirin (162 mg) works better than the standard lower dose (81 mg) at preventing serious high blood pressure conditions during pregnancy. It will enroll over 10,000 pregnant individuals who are at risk for these complica…

This study is testing whether taking low-dose aspirin after a pregnancy with preeclampsia can help repair blood vessel damage and lower the risk of future heart disease. It will involve 40 women who had preeclampsia in the last five years. Researchers will measure how well the wo…

This study is testing whether providing free healthy meals and weekly health coaching to pregnant women can prevent serious complications like gestational diabetes and preeclampsia. Researchers will compare 100 at-risk pregnant women who receive the meal program and coaching to t…

This study is testing whether treating sleep apnea with a CPAP machine during pregnancy can reduce serious high blood pressure conditions like preeclampsia. Researchers will enroll 1,500 pregnant women with mild to moderate sleep apnea and randomly assign them to use either CPAP …

This study is testing whether adding a daily injection of a blood thinner (low molecular weight heparin) to the standard low-dose aspirin pill works better to prevent preeclampsia in high-risk pregnant women. It will involve 100 women in Greece who are identified as high-risk ear…

This study aims to understand why women who had preeclampsia during pregnancy face higher lifelong heart disease risk, even after recovery. Researchers will examine how small blood vessels in the skin respond to salt and a test medication in 40 women who are 12 weeks to 5 years p…

This study aims to understand why low-dose aspirin, a common preventive treatment, sometimes fails to stop preeclampsia from recurring in high-risk pregnancies. Researchers will enroll 130 women with a history of preeclampsia who took aspirin in a later pregnancy. They will compa…

This study aims to understand how pregnant people at risk for preeclampsia process aspirin and how that relates to their metabolic health. Researchers will enroll 50 participants who are already recommended to take aspirin for prevention. The study involves blood tests, urine col…

This study aims to understand if a specific blood test measurement called 'base excess' differs between pregnant women with severe preeclampsia and healthy pregnant women. Researchers will compare blood samples from 100 women at a hospital in Panama to see if abnormal base excess…

This study aims to understand why pregnant women living at high altitudes have higher rates of fetal growth restriction and preeclampsia. Researchers will compare tissue samples from women giving birth in Denver versus Summit County, Colorado, to see if altitude affects blood ves…

This study aims to understand how preeclampsia, a serious pregnancy complication, might lead to future heart problems. Researchers will collect blood and tissue samples from 64 pregnant women, some with preeclampsia and some without, to study tiny particles called exosomes. By an…

This study aims to find new markers in the blood that can show how the placenta is working and how it responds to low-dose aspirin in pregnant people at risk for preeclampsia. Researchers will collect blood samples from up to 1,000 participants during pregnancy to analyze tiny pa…

This study aims to understand what causes preeclampsia, a serious pregnancy complication, by looking for early molecular changes in pregnancy tissue. Researchers will analyze small tissue samples from over 2,000 pregnant women between 9 and 15 weeks of pregnancy. The goal is to f…