PREECLAMPSIA

This study tests whether keeping blood pressure below 140/90 mmHg in pregnant women with preeclampsia or gestational hypertension can safely prolong pregnancy. About 132 women between 23 and 35 weeks pregnant will be randomly assigned to either tighter blood pressure control or u…

This study tests whether taking low-dose aspirin after a pregnancy complicated by preeclampsia can repair lasting blood vessel damage and reduce the higher risk of heart disease these women face. Researchers will measure blood vessel function in 40 women who had preeclampsia in t…

This early-stage study tests a single injection of CBP-4888 in 60 pregnant women hospitalized with preterm preeclampsia, a serious condition involving high blood pressure and organ stress. The goal is to find a safe dose that helps manage the condition while the pregnancy continu…

This study tests whether a one-time IV treatment of stem cell exosomes can repair blood vessel damage in 80 women who recently had preeclampsia. Half receive the treatment, half a placebo. Researchers will check blood markers and blood pressure one week later to see if the therap…

This study tests if taking atorvastatin (a cholesterol-lowering drug) for 3 months after pregnancy can reduce long-term heart disease risk in people who had high blood pressure or preeclampsia during pregnancy. 76 postpartum individuals will receive either atorvastatin or a place…

This study tests a 9-month program for women who had preeclampsia in their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps wit…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This study is testing whether using a CPAP machine during pregnancy can lower the risk of high blood pressure disorders like preeclampsia. Researchers will enroll 1,500 pregnant women with mild to moderate sleep apnea. Participants will be randomly assigned to receive CPAP or usu…

This study tests a medication called ravulizumab in pregnant people with severe preeclampsia or HELLP syndrome, serious conditions that can harm both mother and baby. The goal is to see if the drug can improve health markers and extend pregnancy length. About 14 participants will…

This study tests whether taking spironolactone for three months after giving birth can help lower blood pressure and improve heart health in women who had preeclampsia or high blood pressure during pregnancy. The trial includes 204 women who were overweight before pregnancy and n…

This study tests whether metformin, a drug used for diabetes, can safely prolong pregnancy in women diagnosed with preterm preeclampsia. Currently, the only way to stop the condition is to deliver the baby early, which can cause health problems for the newborn. The trial will enr…

This study is testing new, non-invasive methods to detect early signs of preeclampsia and high blood pressure in pregnant women. Researchers will use a special device to measure blood vessel health and take blood and urine samples. The goal is to find better ways to predict and d…

This study looks at whether three substances in the blood can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 120 pregnant women between 20 and 36 weeks. The goal is to find a b…

This study looks at whether a simple lung ultrasound can detect dangerous fluid buildup in pregnant women with severe preeclampsia. Researchers will scan the lungs of 202 participants at three key times to spot early signs of fluid overload. The goal is to provide doctors with a …

This study tests whether providing healthy meals, nutrition support, and health coaching to high-risk pregnant women can lower their chances of developing gestational diabetes, high blood pressure, or preeclampsia. About 100 women in early pregnancy will be randomly assigned to e…

This study looks at whether natural salicylates found in foods like fruits and vegetables can help prevent preeclampsia, a serious pregnancy complication. Researchers will measure the diet and blood/urine levels of 500 pregnant women (healthy and those with preeclampsia) to see i…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can better prevent preeclampsia in pregnant women at high risk. Preeclampsia is a dangerous condition involving high blood pressure and organ damage. The trial will enroll 100…

This large study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) during pregnancy. About 10,700 pregnant individuals at increased risk will be followed to see which dose works bes…

This study tests whether MitoQ, a type of antioxidant that targets cell powerhouses, can improve blood vessel function in pregnant people with preeclampsia. Researchers will measure blood vessel health in the arm, skin, and placenta. The goal is to see if MitoQ can help prolong p…

This study tests a non-invasive physiotherapy technique called vagal autonomic stimulation with trigger point release, added to standard blood pressure medication, for pregnant women with preeclampsia. The goal is to see if this drug-free approach can better control blood pressur…

This study looks at why women who had preeclampsia during pregnancy are more likely to develop heart disease later in life. Researchers will test how blood vessels in the skin react to salt and a drug called eplerenone in 40 women who had preeclampsia and those who had healthy pr…

This study looks at why low-dose aspirin doesn't always prevent preeclampsia, a serious pregnancy complication. Researchers will analyze genetic and lab factors in 130 women who had preeclampsia before and took aspirin in a later pregnancy. The goal is to find clues that could im…

This study looks for early warning signs of preeclampsia, a serious pregnancy complication, by examining tissue from the placenta and womb lining collected between weeks 9 and 15 of pregnancy. Researchers will compare samples from women who later develop preeclampsia with those w…

This study looks at 500 women who recently gave birth—250 with preeclampsia and 250 without—to see if exercise stress tests can spot early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will track heart function and blood markers over a year. The goa…

This study looks at why pregnant women at high altitude have higher rates of poor fetal growth and preeclampsia. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their blood ve…

This study looks at whether a blood test measuring certain markers can help doctors decide when to induce labor in pregnant women with mild preeclampsia. The goal is to reduce unnecessary inductions without increasing risks for the mother or baby. About 750 women will take part.

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers measure blood vessel stiffness and collect blood samples to learn how these conditions affect long-term health. No new treatments are given; the goal is simply to g…

This study looks at how aspirin affects proteins from the placenta in pregnant people at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will collect blood samples from 1,000 participants during pregnancy to find markers that show how well th…

This study looks at tiny particles called exosomes released from the placenta in pregnant women with preeclampsia. Researchers want to understand how these particles damage blood vessels and lead to heart problems. They will collect blood and placenta samples from 64 women to stu…

This study is testing two new ultrasound methods to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will compare these new scans in 60 pregnant women, some w…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure aspirin byproducts and markers of metabolic health in 50 participants. The goal is to understand if d…

This study looks at whether a blood gas measurement called base excess can help tell how severe preeclampsia is. Researchers will compare 100 pregnant women with severe preeclampsia to healthy pregnant women. If base excess is linked to worse outcomes, it could become a new tool …