Depression drug may mend blood vessels damaged by preeclampsia
NCT ID NCT07715669
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
Women who had preeclampsia are at higher risk for both depression and heart disease later in life. This study investigates whether antidepressant medication can improve blood vessel function in these women. Researchers will measure skin blood vessel responses in 40 women, comparing those with and without a history of preeclampsia and depression. The goal is to understand the link between depression treatment and cardiovascular health after preeclampsia.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- paroxetine hydrochloride and ascorbic acid (vitamin C) delivered locally to the skin via microdialysis
- What this could lead to
- If successful, this research could point toward using antidepressant therapy to lower heart disease risk in women who had preeclampsia.
- What could go wrong
- This is a very early, small study (40 participants) measuring only short-term skin blood vessel responses, not actual heart disease outcomes. Results may not translate to long-term cardiovascular benefits.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Iowa
RECRUITINGIowa City, Iowa, 52242-3521, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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