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Depression drug may mend blood vessels damaged by preeclampsia

NCT ID NCT07715669

Knowledge-focused Sponsor: Anna Stanhewicz, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

Women who had preeclampsia are at higher risk for both depression and heart disease later in life. This study investigates whether antidepressant medication can improve blood vessel function in these women. Researchers will measure skin blood vessel responses in 40 women, comparing those with and without a history of preeclampsia and depression. The goal is to understand the link between depression treatment and cardiovascular health after preeclampsia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
paroxetine hydrochloride and ascorbic acid (vitamin C) delivered locally to the skin via microdialysis
What this could lead to
If successful, this research could point toward using antidepressant therapy to lower heart disease risk in women who had preeclampsia.
What could go wrong
This is a very early, small study (40 participants) measuring only short-term skin blood vessel responses, not actual heart disease outcomes. Results may not translate to long-term cardiovascular benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-24 years old, * 12 weeks - 5 years post pregnancy * one of the following: * history of a normal pregnancy with a current diagnosis of depression, * history of a normal pregnancy without a current diagnosis of depression, * history of a preeclamptic pregnancy with a current diagnosis of depression * history of preeclamptic pregnancy without a current diagnosis of depression. Exclusion Criteria: * history of cardiovascular, metabolic, and/or skin diseases * current or history of tobacco/nicotine/ e-cigarette use * history of gestational diabetes * current antihypertensive or cholesterol-lowering medication * currently pregnant * allergy to materials used during the experiment (e.g. latex), * known allergy to study drugs * currently using SSRI medications

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Conditions

The condition(s) this trial relates to.

depressive disorder preeclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endothelial function Preeclampsia

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • University of Iowa

    RECRUITING

    Iowa City, Iowa, 52242-3521, United States

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