Could High-Dose vitamin D3 shield pregnant women from preeclampsia?

NCT ID NCT07648706

Recruiting now Prevention Sponsor: Sana'a University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two different doses of vitamin D3 supplements in pregnant women who have low vitamin D levels. The goal is to see if a higher dose (50,000 IU every two weeks) is better than a lower dose (5,000 IU weekly) at preventing preeclampsia, a serious pregnancy complication involving high blood pressure. The trial enrolls women with a single baby, between 8 and 18 weeks of pregnancy, and follows them through delivery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin D3
What this could lead to: If successful, this could show that higher vitamin D3 doses during pregnancy reduce the risk of preeclampsia, a dangerous condition for both mother and baby.
What could go wrong: This is a relatively small, single-hospital study, so results may not apply to all populations. The optimal dose and safety of high-dose vitamin D3 in pregnancy are still being explored.

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Conditions

The condition(s) this trial relates to.

vitamin D deficiency preeclampsia prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREECLAMPSIA

Contacts and locations

Locations

Faculty of Medicine and Health Sciences, Sana'a University
RECRUITING

Sanaa, Maeen District, Yemen

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