Can a drug improve blood vessel health in women after preeclampsia?

NCT ID NCT06749418

Recruiting now Knowledge-focused Sponsor: Anna Stanhewicz, PhD Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at why women who had preeclampsia during pregnancy have higher heart disease risk later in life. Researchers will test a drug called eplerenone on small skin blood vessels in 40 women (some with prior preeclampsia, some without) to see if it improves vessel function. The goal is to understand the underlying mechanisms, not to treat or cure the condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eplerenone
What this could lead to: If successful, this study could point toward new ways to reduce cardiovascular disease risk in women who had preeclampsia.
What could go wrong: This is a very early, small study (40 participants) testing a drug locally on skin blood vessels, not a treatment. It may not lead to any clinical changes.

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Conditions

The condition(s) this trial relates to.

preeclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREECLAMPSIA PREECLAMPSIA POSTPARTUM

Contacts and locations

Locations

University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States

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