Higher aspirin dose may better protect pregnant women from dangerous hypertension

NCT ID NCT06468202

Recruiting now Prevention Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) in pregnant women at risk. Over 10,000 participants will be assigned to one of the two doses early in pregnancy. The goal is to find the most effective dose to reduce serious complications for both mother and baby.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin (81 mg or 162 mg daily)
What this could lead to: If it works, this could show that a higher aspirin dose is better at preventing dangerous pregnancy complications like preeclampsia, potentially saving lives.
What could go wrong: This is a large trial, but results may not apply to all populations. Aspirin can cause side effects like bleeding, and the higher dose may not be more effective or could increase risks.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder preeclampsia hypertension, pregnancy-induced prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GESTATIONAL HYPERTENSION HYPERTENSIVE DISORDERS OF PREGNANCY PREECLAMPSIA

Contacts and locations

Locations

Brown University
RECRUITING

Providence, Rhode Island, 02905, United States
Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Eastern Virginia Medical School - Old Dominion University
RECRUITING

Norfolk, Virginia, 23501, United States
Inova HealthSystem
RECRUITING

Falls Church, Virginia, 22042, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine
RECRUITING

Columbus, Ohio, 43210, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Mississippi
RECRUITING

Jackson, Mississippi, 39216, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 27710, United States
University of North Carolina, Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Pittsburg Magee
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Texas, Houston
RECRUITING

Houston, Texas, 77030, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States

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