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Pregnancy complication linked to midlife brain changes?

NCT ID NCT06640842

Knowledge-focused Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitoring. The goal is to understand if these pregnancy complications are linked to later risks for dementia, heart disease, and cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If it works, this could help identify early risk factors for dementia and heart disease in women with a history of hypertensive pregnancy.
What could go wrong
This is a small observational study with only 24 participants, so findings may not apply to all women. It looks for links, not causes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

24 people

The number who actually took part.

Started

Sep 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Women who previously participated in the ADORE, received a hypertensive disorder diagnosis or had a healthy pregnancy during their participation.

Ages

18 to 54 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participated in the ADORE trial ( R01 HD083292) Exclusion Criteria: * History of seizures or Epilepsy * Pregnant at screening * Ineligible to complete MRI due to metal in the body

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Conditions

The condition(s) this trial relates to.

Alzheimer disease cardiovascular disorder dementia hypertension, pregnancy-induced preeclampsia pregnancy disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Brain health Cardiovascular diseases Dementia Gestational hypertension Pre-eclampsia Pregnancy related

Contacts and locations

Locations

  • The University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

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