PREGNANCY RELATED

This study tests whether community-based patient navigators can improve maternal health for Black women in a safety-net health system. 540 pregnant women with unmet social needs will be randomly assigned to receive either standard care or extra support from a navigator from mid-p…

This study tests a short counseling program (about 4 sessions) designed to help pregnant and postpartum women in Cape Town, South Africa, keep taking their daily HIV-prevention pill (PrEP). Many women stop PrEP due to depression or trauma from violence. The program uses cognitive…

This study looks at whether a special form of folic acid (5-MTHF) can improve blood vessel health in pregnant women with high blood pressure or pre-eclampsia. Researchers will measure key molecules in the blood, placenta, and umbilical cord to see if the supplement helps. The tri…

This study tests whether delivering medically tailored groceries to the homes of pregnant women on Medicaid can reduce food insecurity and improve birth outcomes like preterm birth and low birth weight. About 360 pregnant women in Cuyahoga County, Ohio, will receive home-delivere…

This large study in North Carolina tests whether giving clinics data tools and racial equity training, plus offering doula support to high-risk Black patients, can reduce low birthweight and discrimination in prenatal care. About 60,000 patients from 39 clinics will take part. Th…

This study tests whether a simple procedure called membrane stripping (where a doctor sweeps a finger around the cervix to separate the amniotic sac) works as well as a balloon catheter to ripen the cervix before inducing labor. About 400 full-term pregnant women will be randomly…

This study compares two methods of removing the fallopian tubes during a C-section for permanent sterilization: using a hand-held bipolar energy tool versus traditional stitches. Researchers will look at blood loss, completion rates, and costs in 900 women who had the procedure b…

This study tests whether giving regular blood transfusions during pregnancy can reduce sickle cell complications and pregnancy-related problems in women with sickle cell disease. About 50 pregnant women will be randomly assigned to receive transfusions or standard care. The goal …

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This study tests whether giving iron through a vein (IV) early in the second trimester works better than iron pills for treating anemia in pregnancy. About 80 pregnant women with mild iron deficiency will be randomly assigned to one of the two treatments. The goal is to see which…

This study is testing whether two questionnaires (SCOFF-F and EDE-Q) can accurately detect eating disorders in pregnant women, separating them from normal pregnancy-related eating concerns. Researchers will compare answers from 50 pregnant women with and without diagnosed eating …

This study tests a fully online program called Yes and Know for teens aged 14-19. The program includes group sessions and digital tools to teach about sexual health, relationships, and life skills. About 1,200 teens will take part, with half receiving the program and half receivi…

This study looks at the safety of two HIV prevention methods (a long-acting shot and daily pills) in pregnant and breastfeeding women in Malawi. About 621 women who are already using or start these drugs during pregnancy will be followed along with their infants. The goal is to s…

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This study tests a program called Care4mommies that teaches self-compassion skills to pregnant women. The goal is to see if it helps mothers feel better emotionally and bond more strongly with their babies after birth. About 96 pregnant women will take part, and researchers will …

This pilot study tests whether participating in the Lullaby Project—where pregnant women with epilepsy work with musicians to create a personal lullaby—can improve their quality of life and reduce anxiety, depression, and stress. Thirty first-time pregnant women with epilepsy wil…

This study tests whether sexual counseling during pregnancy can improve sexual function, marital adjustment, and emotional health. About 70 pregnant women will receive either counseling or standard care. Researchers will measure changes before delivery and three months after birt…

This study tests whether 8 weeks of diaphragmatic breathing or pelvic stabilization exercises, done at home via video calls, can reduce pain and disability in 60 postpartum women with pregnancy-related pelvic girdle pain. Participants will also receive pelvic anatomy education. T…

This pilot study tests whether using a pelvic wand for perineal massage in late pregnancy and during labor can help women feel more in control and reduce pelvic injuries. Researchers will enroll 140 pregnant women at Beth Israel Deaconess Medical Center. Participants will either …

This study tests a mobile app called BumptUp to see if it helps pregnant and postpartum women in rural areas become more physically active. About 176 women will either use the app or receive an educational brochure. Researchers will track activity levels, weight, diet, blood pres…

This study tests whether giving progesterone (a hormone) after intrauterine insemination (IUI) with mild ovarian stimulation increases the chance of a live birth. About 1,000 couples with unexplained infertility will take part. The goal is to see if this simple support can improv…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study looks at whether giving moms extra education about breastfeeding before they give birth helps them breastfeed exclusively for the first 6 weeks. About 196 first-time or less-experienced mothers will take part. Researchers will compare breastfeeding rates between those …

This study looks at whether simulation training for doctors, nurses, and midwives can reduce the number of cervical exams women receive during labor and make exam results more consistent. Over 1,100 healthcare providers and patients will take part. The goal is to improve care wit…

This study tracks pregnant women with narcolepsy who take pitolisant (Wakix) or other narcolepsy medications, as well as pregnant women without narcolepsy who take pitolisant. Researchers compare pregnancy outcomes, including birth defects, to see if the drug poses risks. The goa…

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) for Black women and birthing persons. Researchers will work with community organizations and advisory boards to identify barriers and facilitators to implementation. The goal is to make the program …

This study follows up to 20 people of any age who took the drug odevixibat while pregnant or breastfeeding. Researchers will collect routine medical data to see if the drug is linked to birth defects, pregnancy complications, or harm to the baby. No extra tests or visits are requ…

This study looks at whether pregnant women who eat 10-14 eggs per week have babies with better brain development compared to those who just follow a healthy prenatal diet. Researchers will measure fetal heart rate and later do brain scans on the infants. The goal is to see if boo…

This study is testing whether a new wireless skin sensor system can safely and accurately monitor the heart rate, breathing, oxygen levels, and temperature of healthy newborns right after birth. 600 babies will wear both the wireless sensors and standard wired monitors for the fi…

This study looks at how anti-seizure medications are processed in the bodies of pregnant women with epilepsy. Researchers will measure drug levels in the blood and urine to understand how much reaches the unborn baby and nursing infant. The goal is to help doctors choose safer do…

This study is developing a smart computer program that can separate a baby's heartbeat from the mother's using sensors placed on the belly. Researchers will collect recordings from 350 pregnant women in their second or third trimester. The goal is to make fetal heart monitoring f…

This study aims to map gene activity in the placenta at two key points in pregnancy: the first trimester and at childbirth. Researchers will analyze small tissue samples from 100 pregnant women to understand how placental cells change over time. The goal is to learn more about no…

This study looks at how women with HIV in the United States decide to feed their babies, whether by breastfeeding or formula. Researchers will interview mothers and track their choices and health outcomes. The goal is to fill gaps in knowledge and create a national registry to be…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track health outcomes for both mothers and babies, such as relapse and withdrawal symptoms. The goal is to find better ways to predict and prevent complic…

This study is collecting information on pregnancy and malaria in 9,500 women aged 15-49 in Kalifabougou, Mali. Researchers will track pregnancies, malaria cases, and pregnancy outcomes like preterm birth and anemia. The goal is to better understand these health issues in the comm…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study tracks 242 pregnant women to measure how their heart rate and blood pressure change from the third month of pregnancy through the postpartum period. Researchers use non-invasive tests like ECG and blood pressure cuffs to understand the body's natural adjustments. The g…

This study tests whether a wrist-worn device can help monitor pregnant women with congenital heart disease. Researchers will track heart rhythms and other data from 50 participants to see if the wearable can detect early signs of trouble. The goal is to improve care and reduce th…

This study follows 60 women with neuromyelitis optica spectrum disorder (NMOSD) who received UPLIZNA during pregnancy or within 6 months before conception. Researchers will collect data on pregnancy outcomes, including birth defects, preterm birth, and infant development over 10 …

This study tests whether small wearable sensors can accurately track movement and walking patterns in 30 pregnant women during early labor, both with and without a low-dose epidural. The goal is to see if these sensors can help monitor pain relief effectiveness, predict fall risk…

This study is testing a special camera (Mueller polarimetric colposcopy) to see if it can measure changes in the cervix during pregnancy. The goal is to find patterns that could help predict if a baby will be born early (preterm). Researchers will study 683 pregnant women, both w…

This study follows 200 pregnant women who take tildrakizumab for conditions like psoriasis, along with a similar group who don't take the drug. Researchers track pregnancy outcomes and infant health up to one year after birth to check for birth defects or other problems. The goal…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study will analyze health records of over 5,600 pregnant women with atopic dermatitis (eczema) to compare infant outcomes between those who used ruxolitinib cream (Opzelura) and those who used topical corticosteroid creams. Researchers will look at rates of major birth defec…

This study follows about 958 pregnant women with mild to moderate eczema (atopic dermatitis) who use ruxolitinib cream (Opzelura) and compares them to similar women who do not use the cream. Researchers track birth defects and other pregnancy outcomes to see if the cream is linke…

This study interviews women who gave birth in French-speaking Belgium within the last year to understand why they chose a particular place of birth and how their childbirth experience was. Researchers also talk to birth companions like doulas and healthcare professionals. The goa…

This study follows 825 pregnant women who need blood thinners for blood clots, observing how these medications are managed around labor and delivery. Researchers aim to see how different strategies affect bleeding risks. The goal is to find safer ways to handle blood thinners dur…

This observational study is looking at the safety of the heart medication mavacamten when taken during pregnancy or while breastfeeding. Researchers will follow about 20 people who have taken at least one dose of mavacamten during pregnancy or breastfeeding, tracking outcomes for…

This study uses MRI to measure pancreas size in pregnant women and their babies, since smaller pancreases are linked to diabetes. Researchers will follow 87 women from early pregnancy to one year after birth. The goal is to see how pancreas changes relate to diabetes, which could…

This study is testing whether a program originally designed for clinics can work in community settings to help pregnant women with a BMI over 30 stay active and healthy. Researchers will enroll 60 expecting mothers to see if the program is easy to use and follow. The goal is to l…

This study tests whether pregnant women with complications like pre-eclampsia or fetal growth restriction can use a remote device at home to monitor their baby's heart rate. Sixty participants between 32 and 37 weeks of pregnancy will try the device daily. Researchers will check …

This study looks at how pregnant and non-pregnant people recover after being in the intensive care unit (ICU) for severe COVID-19. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after leaving the ICU. The goal is to understand the lon…

This study aims to develop a non-invasive blood test that analyzes fetal DNA found in the mother's blood to determine paternity. It is designed for sexual assault victims who become pregnant and need to know the father's identity for legal reasons. The test uses a technique calle…

This study tests whether adjusting room light during labor can improve uterine contractions and reduce the need for C-sections. Researchers will monitor 100 pregnant women, using different light settings (bright, dim, or red light) to see how it affects contractions and melatonin…