New program aims to boost HIV prevention in pregnant women

NCT ID NCT06226155

Recruiting now Prevention Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant women with psychological distress to see if the program is feasible and acceptable. If it works, it could be tested on a larger scale to reduce HIV infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: problem-solving behavioral intervention
What this could lead to: If successful, this program could help pregnant women in Zimbabwe better use PrEP to prevent HIV, reducing new infections in a high-risk population.
What could go wrong: This is a small, early-stage study focused on feasibility and acceptability, not yet testing effectiveness. The results may not apply to other settings or populations.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression pregnancy disorder HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION, ANXIETY HIV INFECTIONS PREGNANCY RELATED

Contacts and locations

Locations

University of Zimbabwe
RECRUITING

Harare, Zimbabwe

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