DEMENTIA

This study is testing the safety of an experimental nasal spray called Foralumab in people with early Alzheimer's disease. The spray aims to reduce harmful inflammation in the brain by targeting the immune system. Sixteen participants will use the spray three times a week for eig…

This early-stage trial is testing if a drug called deferiprone, which removes excess iron, can help people recover thinking skills after a life-threatening brain bleed from a burst aneurysm. Researchers believe iron released by the blood is toxic to the brain and causes memory pr…

This study is testing whether a combination of gentle electrical brain stimulation and daily memory exercises can help improve thinking skills in people with dementia. Researchers will compare different types of stimulation to find the most effective approach for boosting memory …

This study is testing whether an experimental drug called DAOIB can help slow cognitive decline in people with early Alzheimer's disease or mild memory problems. Researchers will give DAOIB to 123 participants for 24 weeks and track their memory, thinking skills, and daily functi…

This study is testing whether the drug donanemab is safe and effective at slowing the progression of early Alzheimer's disease. It will involve about 1,500 people who have mild memory problems and confirmed Alzheimer's-related brain changes. Participants will receive either the d…

This study is testing a year-long training program to help nursing home staff better assess and manage pain in residents with dementia. The program involves monthly team meetings, staff education, mentoring, and tracking pain outcomes. Researchers will compare this intensive appr…

This study is testing a device that combines gentle magnetic brain stimulation with memory and thinking exercises. It aims to see if this non-invasive treatment can help slow or improve thinking problems in people with mild Alzheimer's disease. About 158 participants will receive…

This study is testing a new program in nursing homes to improve how suspected infections are managed in residents with dementia. It aims to see if the program can safely reduce the use of antibiotics and avoid stressful hospital trips and tests. The study will involve about 750 r…

This study is testing whether a caregiver can safely use a home-based, non-invasive brain stimulation device to help improve memory, thinking, and walking in older adults with mild dementia or memory loss. Participants and their caregivers will be trained to use the device at hom…

This study is testing whether specific computer-based brain training exercises can help older adults with mild memory problems maintain their ability to perform daily tasks and delay the onset of dementia. Researchers will compare four different combinations of training exercises…

This study aims to determine whether a newer type of brain scan (tau-PET) is more helpful for doctors than the current standard scan (amyloid-PET) when diagnosing Alzheimer's disease. It will involve 120 people aged 50-85 who have mild memory problems or early-stage dementia. Res…

This study is testing a new, brief iPad-based tool called MyCog to help primary care doctors detect early signs of memory loss and dementia more effectively. It focuses on helping older adults from Black, Hispanic/Latino, and low-income communities who often face delays in diagno…

This study is testing if small, in-home cameras and sensors can spot early changes in mood and daily behavior that might signal memory problems or dementia. Researchers at Stanford University are working with 25 older adults to see if this technology can provide clearer, more fre…

This study is testing if a smartphone app can help detect and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by analyzing changes in a person's speech. Researchers will compare speech recordings from 150 people with these condition…

This study is testing whether a simple, non-invasive eye-tracking test using a VR headset can help detect early signs of cognitive decline. It will compare the eye responses of 140 adults, including people with Alzheimer's disease, mild memory problems, depression-related impairm…

This study is testing whether a tablet-based memory test helps primary care doctors identify early signs of dementia more effectively than usual care. It will involve about 180,000 patients across 26 clinics, where some clinics will use the tablet tool and others will continue th…

This study aims to create a better way to spot early signs of Alzheimer's disease. It will test 6,000 adults aged 50+ using a two-step approach: first, a quick digital app to check memory and thinking, and second, a blood test to look for Alzheimer's-related proteins. The goal is…

This study is testing whether taking a combination of B-vitamins and omega-3 fatty acid supplements for three months can help slow brain aging in older adults. Researchers will measure a specific blood marker linked to brain health and also check for changes in memory, thinking s…

This study is testing whether two different lifestyle programs can help prevent dementia and diabetes in older adults who are at risk. It will enroll 400 African American and non-Hispanic white adults over 60 in the San Francisco Bay Area. One program focuses on aerobic exercise,…

This study is testing investigational drugs to prevent Alzheimer's disease in people who carry a rare genetic mutation that almost guarantees they will develop the disease. It enrolls 280 participants who are currently healthy and have no symptoms, but are within a specific age w…

This large study aims to see if taking a daily cholesterol-lowering statin pill (atorvastatin) can help prevent dementia, disability, and death in healthy adults aged 75 and older. About 20,000 participants will be randomly assigned to take either the statin or a placebo (inactiv…

This study is testing an investigational drug, remternetug, to see if it can prevent or slow the progression of Alzheimer's disease in people who carry a genetic mutation that causes the disease but do not yet have any symptoms. The trial will involve 280 participants who are 18 …

This study is testing an online toolkit designed to help people caring for a spouse with dementia prepare for their own unexpected health problems. The goal is to give caregivers a clear plan to arrange backup care, so they can focus on their own health without worrying about the…

This study is testing whether a 6-week online skills program can help improve sleep for older adults living with memory loss or dementia and their care partners. Researchers want to see if teaching sleep techniques via video calls is practical and helpful for both people in the c…

This study is testing a communication coaching program called COACH-Cog. It's designed to help older adults who have both dementia and cancer, along with their family caregivers, talk more effectively with their doctors about treatment choices. The goal is to make sure the patien…

This study is testing a new support program for people with Alzheimer's or dementia and their caregivers during the transition from a nursing facility to home or another care setting. The program provides extra help and education to nursing facility staff and assigns a specialist…

This study is testing whether creating and playing personalized music playlists can help ease behavioral and psychological symptoms like agitation, anxiety, and apathy in people with dementia. Researchers are working with up to 1,080 participants in care homes and at home to find…

This study is testing an online training program designed to help people who have recently become caregivers for a loved one with dementia. The program uses weekly group video sessions and online materials to teach practical skills and build confidence. Researchers want to see if…

This study is testing a phone-based training program called PICT for family caregivers of people with Alzheimer's or related dementias. The program teaches caregivers how to spot signs of pain in their loved ones and how to talk about it effectively with healthcare providers. Res…

This study is testing whether providing hearing aids and communication support to older adults with both Alzheimer's disease and hearing loss can reduce distressing symptoms like agitation and improve their relationship with their caregiver. Researchers will enroll 300 participan…

This study is creating and testing a short, personalized counseling program for women going through menopause who have a higher risk of dementia. The goal is to help them manage their fears and learn better ways to cope. Researchers will first talk to women in focus groups, then …

This study is testing if a special rideshare service can help older adults and people with memory problems get to their doctor's appointments. It compares a full-service ride where a trained driver helps from door-to-door against a standard curb-to-curb ride. The main goal is to …

This study is testing if a virtual cycling activity can improve the quality of life for older adults with dementia living in nursing homes. About 60 participants will either use a stationary bike with interactive films or continue their usual care. Researchers will measure change…

This study is testing a mobile phone app called DemensiaKITA, which is designed to help people caring for family members with dementia. It will see if using the app improves caregivers' knowledge and skills while reducing their stress and burden. The trial involves 451 caregivers…

This study is testing a special exercise program called 'sport stacking' (quickly stacking and unstacking cups) for people with mild dementia and the family members who care for them. The goal is to see if doing these activities together can help improve the person's thinking ski…

This study is testing whether a special 12-week exercise program can help older adults living in nursing homes. The program aims to improve their strength, balance, walking, and thinking skills, while also trying to reduce their risk of falling. Researchers will compare this exer…

This study is testing a new program called DECLARE that aims to better support family members caring for loved ones with dementia at home. The program involves caregivers completing a short assessment about their needs and experiences, which is then shared with their home health …

This study is testing a new mobile app called CarePair, designed to help family members caring for loved ones with dementia. The app helps caregivers identify their own needs and connects them to local support services. Researchers will see if using the app for six weeks helps re…

This study is testing an online course designed to help family and friends caring for someone with dementia. The course teaches practical skills for navigating complex healthcare, legal, financial, and social service systems. Researchers want to see if the course improves caregiv…

This study is testing whether a 12-week activity program guided by an AI robot can help people with dementia and their family caregivers become more physically active. The program provides personalized activities and is compared to standard community care. Researchers will measur…

This study is testing a new way to teach family caregivers of people with dementia. It compares a special learning method that uses practice quizzes to a traditional reading approach. The goal is to see if the new method helps caregivers remember information better, feel more con…

This study is testing if a special computer-based program can help reduce anxiety and stress in older adults with early-stage memory loss or mild Alzheimer's disease. It also looks at whether the program helps reduce the strain on their family caregivers. Researchers will compare…

This study is testing a 6-week online skills training program for family members caring for someone with Alzheimer's or another dementia. The program, called Learning Skills Together, teaches practical care tasks and coping strategies. Researchers want to see if it helps caregive…

This study is testing whether a new home-based palliative care program can improve comfort and quality of life for people with advanced dementia and reduce stress for their family caregivers. Researchers will compare the program to usual care for 300 patient-caregiver pairs in Ne…

This study is testing whether a new drug called MK-1167, when added to standard Alzheimer's medication, can help improve memory, thinking, and daily function for people with mild to moderate Alzheimer's dementia. Researchers will compare the effects of MK-1167 against a placebo i…

This study aims to understand how a person's daily sleep-wake cycle (circadian rhythm) and other lifestyle factors might be linked to different types and stages of dementia. Researchers will observe 1,200 patients from memory clinics in Paris, collecting data on sleep, activity, …

This study aims to better understand brain inflammation in neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will use PET scans to measure specific inflammation markers in the brains of 184 participants, including both patients and healthy volunteers.…

This study aims to understand if speech therapy tailored for bilingual people can help those with primary progressive aphasia, a condition that causes worsening language problems. Researchers will test 60 bilingual participants to see if practicing in both their languages improve…

This study aims to create and test new tools to assess brain function, especially for conditions like dementia and psychiatric disorders. Researchers will develop phone-based and in-person tests to measure memory, reasoning, and social skills. The goal is to provide doctors with …

This study aims to understand how dementia develops by tracking the memory, thinking, health, and lifestyle of 10,000 people in Scotland over many years. It will gather detailed information to identify risk factors and different patterns of disease progression. The goal is to bui…

This study is testing a new toolkit designed to help primary care doctors and nurses have better conversations with people living with dementia about their future care wishes. It will compare the toolkit to usual care across 20 clinics to see if it leads to more and higher-qualit…

This study aims to understand if a person's sleep and daily rhythm patterns before surgery can help predict who might experience confusion (delirium) after a major joint operation. Researchers will observe 150 adults aged 70+ having orthopedic surgery, tracking their sleep with a…

This study aims to follow 5000 adults over many years to understand what factors lead to brain diseases like stroke and dementia. It will track people who already have a diagnosis, are at high risk, or are currently healthy, using questionnaires and medical records. The goal is t…

This study aims to see if a special, non-invasive eye scan can detect changes in the retina linked to dementia. Researchers will compare scans from 20 people with mild dementia to scans from people without dementia. The goal is to find new ways to identify the disease by looking …

This study aims to find scientific proof for how music therapy helps people with Alzheimer's disease. Researchers will measure brain-related chemicals in the saliva of 60 participants before and after music sessions. The goal is to understand the biological reasons behind music's…

This study aims to understand dementia better by comparing how it's described in novels with the real-life stories of people who have it. Researchers will analyze language from 40 participants, including people with early Alzheimer's and healthy individuals, alongside famous book…

This study aims to find the genetic causes of dementia and movement disorders by analyzing DNA from thousands of people. Researchers are enrolling patients with these conditions, their family members, and healthy volunteers to provide blood or saliva samples. The goal is to ident…

This study aims to understand if COVID-19 vaccines affect brain health, specifically looking for signs of stroke or dementia. Researchers in Hong Kong will follow 500 healthy adults, comparing brain scans and memory tests from before and after vaccination to those from unvaccinat…

This study aims to better understand how dementia and mild cognitive impairment (MCI) affect a person's ability to think, perform daily tasks, and manage their mood. Researchers will look back at the medical records of 151 patients to see how these conditions progress over time. …

This research study aims to collect health information and DNA samples from 50,000 people with serious mental illnesses like depression, bipolar disorder, schizophrenia, or dementia. Researchers will link this data with participants' medical records to look for patterns in geneti…

This project is creating a large registry of people interested in Alzheimer's prevention research. The goal is to connect willing individuals with upcoming studies in their area, which could range from surveys and healthy lifestyle programs to memory tests and new drug trials. By…

This study aims to see if measuring certain proteins in a person's blood can accurately predict who will develop Alzheimer's disease or experience cognitive decline. Researchers will follow 1,800 adults aged 60 and older, some with memory concerns and some without, for several ye…

This study aims to build a detailed research database to help scientists develop better ways to detect, prevent, and treat Alzheimer's disease. It will enroll 1,000 adults aged 60 and older, including those with and without memory problems. Participants will be followed annually …

This study aims to understand how different types of dementia develop and progress over time. Researchers are following over 1,500 people aged 50-90, including those with various dementia types and healthy individuals, across Canada. Participants undergo regular brain scans, memo…

This study aims to see if a small, contactless device placed in the bedroom can detect subtle changes in sleep patterns, walking speed, and daily activity in people with mild memory problems or early Alzheimer's disease. About 40 participants will have the device monitor them at …

This study aims to find genes linked to Alzheimer's disease by collecting genetic samples from families with multiple affected members. It is enrolling up to 10,000 participants from families with at least two living relatives diagnosed with Alzheimer's or dementia. The collected…

This study is testing a specific teaching method to help family caregivers of people with dementia better learn and remember how to manage difficult behaviors and psychological symptoms. Researchers want to see if a practice-based learning approach helps caregivers apply their kn…

This study aims to understand the experiences of extended family members—like grandchildren, siblings, and nieces/nephews—who help care for a loved one with dementia. Researchers will interview 240 caregivers to learn about the challenges they face, the services they use, and the…

This study aims to understand how often certain immune system antibodies are found in people with new memory problems and whether these antibodies play a role in causing or worsening dementia. Researchers will follow 300 adults aged 40-90 with recent cognitive decline to measure …

This study aims to create a better prediction model for how memory and thinking problems worsen over time in people with early dementia or mild cognitive impairment. Researchers will collect blood samples, perform brain scans, conduct memory tests, and gather information from clo…

This study is testing whether a new wearable device and computer software can safely and effectively monitor brain blood flow in people at home. It will involve 140 people, including healthy older adults and those who have had a stroke, dementia, depression, or delirium. The main…

This study aims to understand if people with a hormone disorder called primary aldosteronism are more likely to develop memory problems or dementia. Researchers will follow 1,000 patients for up to 5 years, giving them regular memory tests and health check-ups. The goal is to lea…