Yearly Alzheimer's shot could keep symptoms at bay

NCT ID NCT07602582

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tests whether people with Alzheimer's who already took the drug donanemab benefit from getting it just once a year. About 550 volunteers who finished a previous donanemab study will receive either the drug or a placebo for up to 2.5 years. Researchers will track changes in memory, daily function, and brain plaque levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: donanemab
What this could lead to: If it works, this could show that annual infusions of donanemab help keep Alzheimer's symptoms from getting worse over time.
What could go wrong: This is an extension study, so participants already responded to donanemab. It's unclear if annual dosing alone is enough, and the trial is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE DEMENTIA PLAQUE, AMYLOID

Contacts and locations

Locations

Adult Medicine of Lake County, Inc.
RECRUITING

Mt. Dora, Florida, 32757, United States
Artemis Institute for Clinical Research
RECRUITING

Riverside, California, 92503, United States
Artemis Institute for Clinical Research
NOT_YET_RECRUITING

San Diego, California, 92123, United States
Banner Alzheimer's Institute
NOT_YET_RECRUITING

Phoenix, Arizona, 85006, United States
Boston Center for Memory
RECRUITING

Newton, Massachusetts, 02459, United States
Bradenton Research Center, Inc.
RECRUITING

Bradenton, Florida, 34205, United States
Care Access - Huntington Beach
RECRUITING

Huntington Beach, California, 92648, United States
Care Access - Lake Charles (Bayou Pines)
RECRUITING

Lake Charles, Louisiana, 70601, United States
Care Access - Lima
RECRUITING

Lima, Ohio, 45805, United States
Care Access - South Indianapolis
RECRUITING

Indianapolis, Indiana, 46254, United States
Care Access - Tampa
RECRUITING

Tampa, Florida, 33625, United States
Center for Advanced Research & Education
RECRUITING

Gainesville, Georgia, 30501, United States
Charter Research - Orlando
RECRUITING

Orlando, Florida, 32803, United States
Charter Research - The Villages
RECRUITING

The Villages, Florida, 32162, United States
Citizens Memorial Hospital District
RECRUITING

Bolivar, Missouri, 65613, United States
Clinical Trials Research
RECRUITING

Sacramento, California, 95821, United States
Conquest Research
RECRUITING

Winter Park, Florida, 32789, United States
Consano Clinical Research, LLC
NOT_YET_RECRUITING

Shavano Park, Texas, 78231, United States
Covenant Medical Center
NOT_YET_RECRUITING

Waterloo, Iowa, 50702, United States
Emerald Coast Neurology - Airport Boulevard
RECRUITING

Pensacola, Florida, 32504, United States
Finlay Medical Research
RECRUITING

Greenacres City, Florida, 33467, United States
Finlay Medical Research
RECRUITING

Miami, Florida, 33126, United States
Gadolin Research
RECRUITING

Beaumont, Texas, 77702, United States
Great Lakes Clinical Trials - Andersonville
RECRUITING

Chicago, Illinois, 60640, United States
Headlands Research Orlando
RECRUITING

Orlando, Florida, 32803, United States
Healthy Brain Clinic
RECRUITING

Long Beach, California, 90804, United States
Indago Research & Health Center, Inc
RECRUITING

Miami Lakes, Florida, 33016, United States
Infectious Disease Doctors Medical Group, APC
RECRUITING

Walnut Creek, California, 94598, United States
Irvine Clinical Research
RECRUITING

Irvine, California, 92614, United States
Jacksonville Center for Clinical Research
RECRUITING

Jacksonville, Florida, 32216, United States
Josephson Wallack Munshower Neurology, PC
RECRUITING

Indianapolis, Indiana, 46256, United States
K2 Medical Research - Tampa
NOT_YET_RECRUITING

Tampa, Florida, 33634, United States
K2 Medical Research ORLANDO
RECRUITING

Maitland, Florida, 32751, United States
MedVadis Research Corporation
NOT_YET_RECRUITING

Waltham, Massachusetts, 02451, United States
Merritt Island Medical Research, LLC
RECRUITING

Merritt Island, Florida, 32952, United States
Monroe Biomedical Research
NOT_YET_RECRUITING

Monroe, North Carolina, 28112, United States
NDx Clinical Research, Inc.
NOT_YET_RECRUITING

Dayton, Ohio, 45459, United States
National Center for Geriatrics and Gerontology
NOT_YET_RECRUITING

Ōbu, 474-8511, Japan
North Georgia Clinical Research
RECRUITING

Woodstock, Georgia, 30189, United States
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States
Northwest Clinical Trials
RECRUITING

Boise, Idaho, 83704, United States
P-One Clinic
NOT_YET_RECRUITING

Hachiōji, 192-0071, Japan
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Providence Medical Foundation
RECRUITING

Santa Rosa, California, 95403, United States
Revival Research Institute, LLC
NOT_YET_RECRUITING

Southfield, Michigan, 48075, United States
SCB Research Center
NOT_YET_RECRUITING

Bayamón, 00961, Puerto Rico
Samoncho Clinic
NOT_YET_RECRUITING

Shinjuku, 160-0017, Japan
Senior Adults Specialty Research
NOT_YET_RECRUITING

Austin, Texas, 78757, United States
Suncoast Clinical Research, Inc.
RECRUITING

New Port Richey, Florida, 34652, United States
Syrentis Clinical Research
RECRUITING

Santa Ana, California, 92705, United States
The Cognitive and Research Center of New Jersey
RECRUITING

Springfield, New Jersey, 07081, United States
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77054, United States
Tokyo Metropolitan Institute for Geriatrics and Gerontology
NOT_YET_RECRUITING

tabashi City, 173-0015, Japan
Tokyo-Eki Center-building Clinic
NOT_YET_RECRUITING

Chūōku, 103-0027, Japan
Universal Research Group
RECRUITING

Tacoma, Washington, 98405, United States
VIN - Aventura
RECRUITING

Aventura, Florida, 33180, United States
VIN-Andrew Lerman
RECRUITING

Miami, Florida, 33133, United States
Vector Clinical Trials
RECRUITING

Las Vegas, Nevada, 89128, United States
Yotsuya Internal Medicine Clinic
NOT_YET_RECRUITING

Shinjyuku, 160-0017, Japan

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