Yearly Alzheimer's shot could keep symptoms at bay
NCT ID NCT07602582
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether people with Alzheimer's who already took the drug donanemab benefit from getting it just once a year. About 550 volunteers who finished a previous donanemab study will receive either the drug or a placebo for up to 2.5 years. Researchers will track changes in memory, daily function, and brain plaque levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
donanemab
What this could lead to
If it works, this could show that annual infusions of donanemab help keep Alzheimer's symptoms from getting worse over time.
What could go wrong
This is an extension study, so participants already responded to donanemab. It's unclear if annual dosing alone is enough, and the trial is still recruiting.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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Adult Medicine of Lake County, Inc.
NOT_YET_RECRUITINGMt. Dora, Florida, 32757, United States
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Artemis Institute for Clinical Research
NOT_YET_RECRUITINGRiverside, California, 92503, United States
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Artemis Institute for Clinical Research
NOT_YET_RECRUITINGSan Diego, California, 92123, United States
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Banner Alzheimer's Institute
NOT_YET_RECRUITINGPhoenix, Arizona, 85006, United States
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Boston Center for Memory
NOT_YET_RECRUITINGNewton, Massachusetts, 02459, United States
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Bradenton Research Center, Inc.
RECRUITINGBradenton, Florida, 34205, United States
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Care Access - Huntington Beach
NOT_YET_RECRUITINGHuntington Beach, California, 92648, United States
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Care Access - Lake Charles (Bayou Pines)
NOT_YET_RECRUITINGLake Charles, Louisiana, 70601, United States
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Care Access - Lima
NOT_YET_RECRUITINGLima, Ohio, 45805, United States
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Care Access - South Indianapolis
NOT_YET_RECRUITINGIndianapolis, Indiana, 46254, United States
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Care Access - Tampa
NOT_YET_RECRUITINGTampa, Florida, 33625, United States
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Center for Advanced Research & Education
NOT_YET_RECRUITINGGainesville, Georgia, 30501, United States
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Charter Research - Orlando
RECRUITINGOrlando, Florida, 32803, United States
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Charter Research - The Villages
RECRUITINGThe Villages, Florida, 32162, United States
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Citizens Memorial Hospital District
NOT_YET_RECRUITINGBolivar, Missouri, 65613, United States
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Clinical Trials Research
NOT_YET_RECRUITINGSacramento, California, 95821, United States
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Conquest Research
NOT_YET_RECRUITINGWinter Park, Florida, 32789, United States
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Consano Clinical Research, LLC
NOT_YET_RECRUITINGShavano Park, Texas, 78231, United States
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Covenant Medical Center
NOT_YET_RECRUITINGWaterloo, Iowa, 50702, United States
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Emerald Coast Neurology - Airport Boulevard
RECRUITINGPensacola, Florida, 32504, United States
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Finlay Medical Research
NOT_YET_RECRUITINGGreenacres City, Florida, 33467, United States
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Finlay Medical Research
NOT_YET_RECRUITINGMiami, Florida, 33126, United States
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Gadolin Research
RECRUITINGBeaumont, Texas, 77702, United States
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Great Lakes Clinical Trials - Andersonville
NOT_YET_RECRUITINGChicago, Illinois, 60640, United States
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Headlands Research Orlando
NOT_YET_RECRUITINGOrlando, Florida, 32803, United States
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Healthy Brain Clinic
RECRUITINGLong Beach, California, 90804, United States
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Indago Research & Health Center, Inc
NOT_YET_RECRUITINGMiami Lakes, Florida, 33016, United States
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Infectious Disease Doctors Medical Group, APC
NOT_YET_RECRUITINGWalnut Creek, California, 94598, United States
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Irvine Clinical Research
RECRUITINGIrvine, California, 92614, United States
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Jacksonville Center for Clinical Research
NOT_YET_RECRUITINGJacksonville, Florida, 32216, United States
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Josephson Wallack Munshower Neurology, PC
RECRUITINGIndianapolis, Indiana, 46256, United States
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K2 Medical Research - Tampa
NOT_YET_RECRUITINGTampa, Florida, 33634, United States
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K2 Medical Research ORLANDO
RECRUITINGMaitland, Florida, 32751, United States
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MedVadis Research Corporation
NOT_YET_RECRUITINGWaltham, Massachusetts, 02451, United States
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Merritt Island Medical Research, LLC
NOT_YET_RECRUITINGMerritt Island, Florida, 32952, United States
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Monroe Biomedical Research
NOT_YET_RECRUITINGMonroe, North Carolina, 28112, United States
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NDx Clinical Research, Inc.
NOT_YET_RECRUITINGDayton, Ohio, 45459, United States
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National Center for Geriatrics and Gerontology
NOT_YET_RECRUITINGŌbu, 474-8511, Japan
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North Georgia Clinical Research
NOT_YET_RECRUITINGWoodstock, Georgia, 30189, United States
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Northwest Clinical Research Center
RECRUITINGBellevue, Washington, 98007, United States
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Northwest Clinical Trials
RECRUITINGBoise, Idaho, 83704, United States
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P-One Clinic
NOT_YET_RECRUITINGHachiōji, 192-0071, Japan
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Progressive Medical Research
NOT_YET_RECRUITINGPort Orange, Florida, 32127, United States
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Providence Medical Foundation
RECRUITINGSanta Rosa, California, 95403, United States
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Revival Research Institute, LLC
NOT_YET_RECRUITINGSouthfield, Michigan, 48075, United States
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SCB Research Center
NOT_YET_RECRUITINGBayamón, 00961, Puerto Rico
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Samoncho Clinic
NOT_YET_RECRUITINGShinjuku, 160-0017, Japan
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Senior Adults Specialty Research
NOT_YET_RECRUITINGAustin, Texas, 78757, United States
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Suncoast Clinical Research, Inc.
NOT_YET_RECRUITINGNew Port Richey, Florida, 34652, United States
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Syrentis Clinical Research
RECRUITINGSanta Ana, California, 92705, United States
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The Cognitive and Research Center of New Jersey
NOT_YET_RECRUITINGSpringfield, New Jersey, 07081, United States
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The University of Texas Health Science Center at Houston
NOT_YET_RECRUITINGHouston, Texas, 77054, United States
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Tokyo Metropolitan Institute for Geriatrics and Gerontology
NOT_YET_RECRUITINGtabashi City, 173-0015, Japan
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Tokyo-Eki Center-building Clinic
NOT_YET_RECRUITINGChūōku, 103-0027, Japan
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Universal Research Group
RECRUITINGTacoma, Washington, 98405, United States
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VIN - Aventura
RECRUITINGAventura, Florida, 33180, United States
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VIN-Andrew Lerman
NOT_YET_RECRUITINGMiami, Florida, 33133, United States
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Vector Clinical Trials
RECRUITINGLas Vegas, Nevada, 89128, United States
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