DEMENTIA

This Phase 2 study tested whether XPro1595 could help people with early Alzheimer's disease who show signs of brain inflammation. The trial involved 208 participants aged 50-85 who received either the drug or a placebo for 24 weeks. Researchers measured changes in memory, thinkin…

This study tested whether simple electronic reminders could help doctors and caregivers safely reduce unnecessary or risky medications for people with dementia. Researchers sent automated messages to both doctors and patients' caregivers before appointments, suggesting they discu…

This study tested a one-year virtual support program for older adults with dementia and their caregivers. Nurses and social workers provided regular check-ins to address patient and caregiver needs, using standard plans for managing symptoms, stress, and medications. The main goa…

This study tested whether a non-invasive brain stimulation technique could improve thinking skills in veterans with mild cognitive impairment or early dementia. Researchers used magnetic pulses on the forehead to stimulate brain areas involved in memory and decision-making. They …

This study tested a training program and toolkit to help home care workers and family members provide better nutritional support for people with dementia living at home. Researchers worked with caregivers and people with dementia to adapt the program, then trained home care worke…

This study aimed to find the best and safest dose of a supplement called nicotinamide riboside (NR), a form of vitamin B3, for people with Alzheimer's disease. Researchers tested three different daily doses (1000mg, 2000mg, and 3000mg) against a placebo in 80 participants over 12…

This study tested a remote care program for people with dementia and their family caregivers. Over 1,200 patient-caregiver pairs across six U.S. health systems received 12 months of support via phone and web from trained navigators supervised by dementia specialists. The research…

This large study tested a program to help nursing home residents with Alzheimer's and their families plan for future medical care. The goal was to reduce stressful and unwanted hospital visits by making sure a patient's treatment preferences are clearly known and respected by the…

This study tested whether a computer program that analyzes speech patterns can help detect early signs of memory problems and dementia. Researchers compared the AI's analysis of how people talk with results from standard paper-and-pencil memory tests. The goal was to see if speec…

This study tested a computer program designed to help primary care doctors identify older adults at risk for dementia or memory loss. The tool, integrated into the clinic's electronic health record, flagged at-risk patients and gave doctors resources for next steps like assessmen…

This study tested a new program designed to check for memory and thinking problems in older adults after they leave the intensive care unit (ICU). It involved 109 people aged 60 and older who had a long ICU stay. The program screened patients at 6 weeks and 6 months after dischar…

This study tested whether specific proteins in the blood can accurately diagnose Alzheimer's disease. Researchers compared blood test results from 342 patients with results from the current standard spinal fluid test and clinical assessments. The goal was to see if a less invasiv…

This study tested a new digital tool that scans patients' electronic health records to find older adults who might have undetected memory problems or be at risk for Alzheimer's disease. Researchers wanted to see if the tool was practical to use in primary care clinics and if send…

This study tested a new type of blood test designed to help diagnose Alzheimer's disease. Researchers collected blood and urine samples from 150 people, including those with Alzheimer's, other brain diseases, and healthy individuals. The goal was to see if a special chip that pre…

This study tested whether a new blood test could accurately diagnose Alzheimer's disease. Researchers compared blood samples from 200 people—some with Alzheimer's and some healthy—over two years. They measured two specific protein changes in the blood to see if they could reliabl…

This study tested a new computer tool called eRADAR that scans patients' existing electronic health records for clues that might signal a high risk of dementia. The goal was to see if using this tool could help primary care doctors identify more cases of dementia earlier. Over 1,…

This study aimed to see if a combined lifestyle program could help prevent memory decline in older adults at risk for dementia. Researchers in Kerala, India, first measured how common mild memory problems were in 481 adults aged 50-65. They then tested a one-month program with 20…

This small pilot study tested an online educational program designed to teach people about dementia and lifestyle changes that may help prevent it. The study involved 20 adults who were at increased risk for dementia but did not have it yet. Researchers wanted to see if the onlin…

This study tested a new website tool designed to help caregivers of people with dementia who also have trouble swallowing. Researchers wanted to see if using the website reduced feelings of stress and burden for caregivers. They compared two groups: one that had access to the web…

This study tested whether an online tool called WeCareAdvisor could help caregivers of people with dementia. 262 caregivers used the web-based tool for 3-6 months to get advice on managing challenging behaviors like agitation or anxiety. Researchers measured if the tool reduced c…

This study tested a new in-home technology system designed to help family members caring for loved ones with dementia or memory loss. The system uses sensors, smart devices, and apps to monitor safety and provide support, aiming to reduce the caregiver's stress, anxiety, and feel…

This study tested whether a specially designed mobile app could help family members caring for someone with dementia. Researchers enrolled 75 caregivers and asked half to use the app daily for two months. The goal was to see if the app could reduce the caregivers' stress, improve…

This study tested an 8-week online course designed specifically for Black Americans caring for a family member with dementia. The course aimed to help caregivers feel more confident, reduce their stress and anxiety, and improve their ability to find information and work with doct…

This study tested whether a dissolving film medication called BXCL501 can safely reduce agitation episodes in people with dementia. About 150 participants aged 65+ living in care facilities received either a low dose, high dose, or placebo film when agitation occurred over 12 wee…

This study tested a new way to help doctors and caregivers decide which medications might be safely reduced or stopped for people living with dementia. It compared a patient-centered planning method against usual care. The goal was to lower treatment burden, improve shared decisi…

This small pilot study explored whether adding horse interaction to standard memory workshops could help people with mild to moderate dementia. Researchers compared three groups: one doing memory activities with horses, one doing traditional memory workshops, and one with no spec…

This small pilot study tested a program to help safely reduce the number of unnecessary or potentially harmful medications taken by people with dementia living in assisted living. A clinician reviewed each participant's medications and made recommendations to stop or lower doses,…

This small pilot study tested whether a telehealth program combining music therapy and social work support could improve the well-being of older adults living at home. Twenty participants, some with and some without dementia, received sessions over video calls. Researchers measur…

This study tested whether adding game-like features to a memory-assist app could help people with mild to moderate dementia stay more engaged with the technology. Researchers compared the app with and without these features over six months to see if the gamified version improved …

This study tested whether having a special conversation about personal care priorities could help people with mild memory loss or dementia. 178 patients received information before a clinic visit and could talk with a trained helper about what matters most to them. Researchers th…

This study tested whether a simple program could be used in nursing homes to help residents with dementia. The program involved care staff doing two short, personalized activities each week with residents for six months. Researchers wanted to see if this was practical to do and i…

This study tested a new support program for people caring for a family member with dementia at home. The program provided educational materials and resources through home-based primary care practices. Researchers wanted to see if the program was practical to use and acceptable to…

This study tested whether an online group therapy program could help slow thinking and memory problems in people with mild to moderate dementia. Researchers compared people who were offered the virtual therapy sessions to those who received standard care. The goal was to see if t…

This study tested whether a long-term exercise program could help people with moderate to severe dementia living in nursing homes maintain their ability to perform daily tasks like bathing and dressing. It compared a group doing regular exercise to a control group participating i…

This study tested a new approach to help people in the early stages of dementia. Researchers worked directly with 61 participants to co-design a personalized plan of meaningful activities, aiming to improve their well-being and sense of control. The goal was to see if this tailor…

This study tested a new home-based coaching program designed to help older adults with memory loss who live alone. The program involved weekly meetings with a coach to help participants stay active, safe, and socially connected at home. Researchers wanted to see if the program wa…

This study developed and tested a mobile app designed to help people caring for family members with dementia. The app aimed to reduce feelings of depression, anxiety, and burden while improving caregivers' knowledge and coping skills. Researchers worked with 59 caregivers in Sing…

This study tested a distance-learning program to train family caregivers of people with Alzheimer's dementia or traumatic brain injury (TBI). The goal was to teach strategies to reduce care-resistant behaviors—like agitation or aggression during bathing or taking medicine—to impr…

This study tested whether a gentle, at-home brain stimulation treatment could help people with mild to moderate Alzheimer's. One hundred participants used a device at home for 30 minutes, five days a week, for six months. The goal was to see if this non-invasive stimulation could…

This study tested whether a simple checklist could help emergency room staff better recognize and treat pain in people with dementia. Researchers enrolled 714 older adults with dementia who came to the ER with hip pain. They checked if prompting doctors to use a special pain obse…

This study tested a smart home system designed to help Spanish-speaking caregivers of people with dementia or memory problems. The system uses sensors and internet-connected devices to monitor the person being cared for and provide support to reduce caregiver stress, anxiety, and…

This small pilot study from Mayo Clinic tested whether weighted blankets could help reduce agitation and distressing symptoms in people with dementia. Researchers gave specially weighted blankets to 30 hospitalized patients with dementia and measured changes in their agitation, a…

This study tested if a smart electric vehicle could help people with Parkinson's disease or dementia walk better. 120 participants aged 60-85 used the vehicle, which provided real-time feedback during a 45-minute walking training session. Researchers measured if this training imp…

This study tested whether giving robotic companion pets to hospitalized patients with dementia could improve their hospital stay. Researchers gave 106 patients aged 65+ a robotic pet to keep during their stay and compared them to patients receiving standard care. They measured if…

This study tested a new online tool designed to make it easier for caregivers to help people with dementia share their life stories. The tool uses speech-to-text and artificial intelligence to create personal storybooks from conversations. Researchers wanted to see if using these…

This study tested a specialized palliative care program for people hospitalized with late-stage Alzheimer's or related dementias and their family caregivers. The program aimed to provide better symptom management, support decision-making, and coordinate care after leaving the hos…

This study tested whether a friendly robot could help people with dementia or memory problems feel more socially connected and engaged. For three weeks, residents, their families, and staff in an assisted living community tried using a robot that led activities like trivia and ga…

This study tested whether combining two traditional Chinese medicine techniques—acupuncture and acupressure—could help elderly people with mild to moderate dementia. Researchers enrolled 236 participants from care homes and assigned them to receive either standard care, acupunctu…

This small, completed study tested whether special 'transitional-state' snacks—foods that change texture—could be a safe and acceptable way to improve nutrition for people with dementia living at home. Researchers worked with 10 participants to see if these ready-made, nutrient-d…

This study tested if a gentle, non-invasive electrical stimulation applied to the ear could help older adults with frailty. Over two weeks, 80 participants either received the real stimulation or a fake version, while all continued their usual rehab therapies. Researchers measure…

This study tested whether an online sleep improvement program is practical and acceptable for people with mild memory problems or early-stage dementia who also have trouble sleeping. Researchers enrolled 30 older adults to try the digital program, which teaches techniques to impr…

This study tested a new home care system for people with dementia. It involved smart clothing that monitors the wearer's safety and an app that alerts family caregivers. The goal was to see if this technology helps caregivers feel more prepared and less stressed, and if it improv…

This study tested a program called Tele-STELLA, which uses video calls to support family members caring for a loved one with moderate to severe dementia. Over 375 caregivers worked with trained guides from their own homes to learn strategies for managing difficult behaviors like …

This study tested whether a nurse-led support program could help people with dementia living at home continue making their own daily decisions for as long as possible. The program trained nurses to focus on what people with dementia can still do, rather than taking over tasks too…

This study tested a new way to provide hearing care to people living with dementia at home. A speech-language pathologist delivered affordable hearing help instead of an audiologist. Researchers wanted to see if this improved patients' behavioral symptoms and overall quality of l…

This study tested whether starting brain training exercises early during a hospital stay could help older adults (65+) recover their thinking skills after experiencing sudden, severe confusion (delirium). 283 patients were randomly assigned to receive either the special cognitive…

This study tested an online workshop designed to help family caregivers of people with dementia. The 6-week program taught caregiving skills and stress management. Researchers enrolled 109 caregivers to see if the workshop was practical to run and acceptable to participants, with…

This study tested a 4-week oral health program for older adults with dementia at a day care center. The program aimed to improve mouth cleanliness and functions like swallowing. Researchers measured changes in oral hygiene and function to see if the structured care routine was he…

This small study tested a tablet app called 'Gotcha!' designed to help people with mild to moderate dementia who struggle to remember names. Participants used the app at home for daily practice over six weeks, trying to relearn the names of 6-10 important people in their lives. R…

This small study explored whether listening to personally meaningful music could improve alertness and brain function in people with moderate to severe Alzheimer's disease. Ten participants listened to short, emotionally significant songs and nature sounds while researchers measu…

This study tested a virtual companion program called MEMORI Corps. It matched trained senior volunteers with people living with dementia at home to provide regular companionship and personalized activities. The goal was to reduce social isolation for the person with dementia, eas…

This study tested a home device called Care4AD, designed to help people caring for a loved one with Alzheimer's or dementia. The device helps coordinate daily care tasks and provides reminders and activities. Researchers wanted to see if using the device for three months could re…

This study tested two simple treatments to help people with Alzheimer's or other dementias swallow more safely. Researchers wanted to see if tongue-strengthening exercises or a saliva-moistening gel could reduce choking risk and prevent pneumonia. The study involved 76 patient-ca…

This study looked at whether using adult day services helps reduce stress for Black family members caring for loved ones with dementia. Researchers measured stress through questionnaires and saliva tests in 42 caregivers. The goal was to understand if regular breaks through day s…

This study tested a 6-week program to help caregivers of people with dementia. Participants wore an Apple Watch to track their sleep and activity patterns and received weekly coaching calls. The goal was to help caregivers establish healthier daily routines to reduce symptoms of …

This study tested whether a single 90-minute educational class could improve healthcare students' attitudes toward people living with dementia. 400 nursing and public health students in Indonesia participated in a class that included lectures, a game, and short dramas. Researcher…

This study tested a new program where emergency room pharmacists review the medications of patients with dementia or mild memory problems. The goal was to see if pharmacists could identify and recommend stopping unnecessary or potentially harmful brain-affecting drugs, and then c…

This study looked at whether people who develop long-lasting nerve pain after a shingles outbreak are more likely to be diagnosed with dementia later on. Researchers analyzed the health records of nearly 69,000 adults who had shingles, comparing those who got this chronic pain to…

This study tested if a simple wrist sensor could detect early signs of agitation in people with dementia. Researchers monitored the skin's electrical activity in 21 patients to see if it changed before disruptive outbursts occurred. The goal was to find a warning signal that coul…

This study tested whether a fun, interactive program using hip-hop music and dance could improve knowledge about Alzheimer's disease and dementia. It involved over 2,200 parents and their elementary school children from New York City communities. Researchers wanted to see if this…

This study tested an online educational program designed to help family caregivers of people with dementia better understand symptoms and treatments. Researchers enrolled 65 informal caregivers in the U.S. to see if a specific learning technique called 'retrieval practice' could …

This study developed and tested a communication program called KNOW to help people with early-stage Alzheimer's or dementia and their family caregivers talk about and plan for future medical care. The program taught communication and relaxation techniques to make these difficult …

This research surveyed 219 family caregivers in the U.S. to understand how managing swallowing problems (dysphagia) in a loved one with dementia adds to their stress and burden. The goal is to gather information to help design better future support programs for caregivers. The st…

This study tested whether using virtual reality (VR) headsets to teach about dementia is more effective than standard education for older adults with mild memory concerns. Researchers in Taiwan randomly assigned 139 participants to either try a VR education program or receive reg…

This study tested a simple way to help people with dementia living in assisted living centers plan for their future medical care. Researchers sent some residents an informational video about advance care planning, while others had the usual care discussions with their doctors. Th…

This study aimed to see if following a vegetarian diet is linked to developing fewer chronic diseases over time. Researchers followed over 18,000 Taiwanese Buddhists, comparing health outcomes between vegetarians and non-vegetarians. They tracked participants' health records for …

This study looked at whether a special brain scan (amyloid PET) helps doctors make better care decisions for people with memory problems or dementia. It followed over 6,000 Medicare patients from diverse backgrounds to see if the scan results changed their treatment plans and hea…

This study tested whether a virtual reality (VR) experience could help people caring for someone with dementia. 227 caregivers were randomly assigned to either try a VR simulation of what dementia feels like or attend a traditional lecture. Researchers measured if the VR experien…

This study followed 404 patients for 10 years after their hip fracture surgery. Researchers wanted to see if signs of early Alzheimer's disease, measured in spinal fluid at the time of surgery, were linked to how long patients lived. The goal is to better understand long-term ris…

This study looked back at the medical records of 683 older adults with dementia to see how often they were prescribed blood-thinning medications like aspirin. Researchers wanted to check if these prescriptions followed current medical guidelines for patients with different types …

This study aimed to identify what factors make someone more or less likely to develop dementia after having a stroke. Researchers followed 229 stroke patients for five years, regularly checking their memory, thinking skills, and brain health with scans and tests. By comparing pat…

This study tested a new way to help caregivers of people with dementia learn and remember important health information. Researchers compared two learning methods—restudying material versus taking practice tests with feedback—to see which helped 73 caregivers remember details abou…

This study looked back at the health records of nearly 1 million Canadian adults to understand how the COVID-19 pandemic affected their regular care for long-term conditions like diabetes, heart failure, and depression. Researchers compared the number of doctor visits, tests, and…