DEMENTIA

This study tests a drug called DAOIB in 123 people with early-stage Alzheimer's or mild cognitive impairment. Participants take the drug for 24 weeks, and researchers check their thinking skills and blood markers every 8 weeks. The goal is to see if DAOIB can slow down memory los…

This study tests an oral medication called deferiprone in people who have had a brain bleed from a ruptured aneurysm. The drug aims to safely remove excess iron from the brain, which can cause memory loss and dementia. About 66 adults will be randomly assigned to receive either d…

This study tests whether taking B-vitamins and omega-3 fatty acids together can slow brain aging in older adults at risk for dementia. Researchers will measure a blood marker of brain health and track thinking skills over 3 months. The goal is to see if this simple nutritional ap…

This study compares a multicomponent exercise program (combining strength, balance, and walking exercises) with a simple stretching and relaxation program in 60 nursing home residents who have frailty or dementia. The goal is to see if the exercise program improves physical funct…

This study tests a nasal spray called Foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The goal is to see if it safely reduces brain inflammation and improves thinking. Participants use the spray three times a week for 8 weeks, with breaks, and are foll…

This study looks at whether specific brain-training exercises can help older adults with mild memory problems keep their daily living skills and delay dementia. About 1,300 participants aged 55–89 will try different combinations of cognitive training or general mental stimulation…

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This study tests whether a smartphone app can record and analyze speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

This study looks at whether a newer type of brain scan (Tau-PET) helps doctors diagnose Alzheimer's disease more accurately than the standard scan (Amyloid-PET). Researchers will enroll 120 adults aged 50-85 with mild memory problems or early dementia. Participants will receive b…

This study tests a simple 5-minute cognitive assessment called 5-Cog to help primary care doctors detect dementia and mild cognitive impairment earlier. It involves 6,600 older adults in 22 clinics in the Bronx and Indiana, focusing on communities that often face health dispariti…

This study aims to improve early detection of Alzheimer's disease in adults aged 50 and older who live in the community and have no known memory problems. Participants will first complete a quick digital screening that includes a questionnaire, a thinking test, and a risk predict…

This study tests LUMEN, an AI-powered conversation tool that helps caregivers describe their loved one's memory and thinking changes in a structured way. About 60 caregivers and doctors in UK memory clinics will use the tool and give feedback on its ease of use and usefulness. Th…

This study tests a new, ultra-low radiation PET scan to detect Alzheimer's disease and other dementias. Researchers aim to reduce radiation exposure by 10 to 100 times compared to current scans. About 200 adults, including healthy volunteers and those with memory problems, will r…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This large study in Denmark will give the shingles vaccine (Shingrix) to about 162,000 adults aged 65 and older to see if it lowers their risk of heart attacks, strokes, and dementia. Half will get the vaccine, half will not. Researchers will track health records for several year…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults who are at risk for dementia and diabetes. One program focuses on aerobic exercise, the other on a healthy diet called the MIND diet. The goal is to see if these programs can impro…

This study looks at whether regular aerobic exercise can help prevent Alzheimer's and related dementias in older adults who are at higher risk. Researchers will enroll 264 inactive men and women aged 50-80 with memory concerns but no dementia. Participants will either do aerobic …

This study tests a drug called remternetug to see if it can prevent or slow Alzheimer's disease in people who have a gene mutation that causes the disease. About 280 adults with this high genetic risk will receive either the drug or a placebo. The goal is to stop harmful protein …

This study tests a digital program called Exercogs® that combines brain games, physical exercise, and social activities using augmented reality. The goal is to see if it can prevent or slow cognitive decline in adults aged 55 and older who have at least one risk factor for dement…

This study tests whether investigational drugs can prevent or slow the buildup of harmful proteins in the brain of people who carry a gene mutation that causes early-onset Alzheimer's. About 280 participants will receive either the study drug or a placebo. The goal is to see if e…

This study is testing whether taking atorvastatin (a statin) can prevent dementia, disability, and death in healthy adults aged 75 and older who do not have heart disease or dementia. About 20,000 participants will receive either the drug or a placebo. The goal is to see if this …

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with cognitive training can improve memory, thinking, and mood in people with mild cognitive impairment or early-stage dementia. Fifty participants will receive both real and placebo stimulation in …

This study tests a culturally adapted program called ACES for Black immigrant caregivers of people with dementia. The goal is to see if it helps reduce depression and caregiver burden while improving quality of life. About 150 care partners and their loved ones will take part ove…

This study tests a transitional care program for people with Alzheimer's or dementia who are leaving a skilled nursing facility to go home, to assisted living, or to long-term care. The program also supports their caregivers. The goal is to see if the program can reduce caregiver…

This study tests whether a month of personalized calming music at bedtime can improve sleep for people with dementia and reduce stress for their caregivers. About 144 participants (72 pairs of a person with dementia and their caregiver) will use a mobile app or receive sleep educ…

This study tests an online course called CAN-DO designed to help family members caring for someone with dementia. 270 caregivers will take the course either right away or after a wait, and complete surveys over 6 months. The goal is to see if the course reduces stress and improve…

This study tests a program called BrainLive Connect, where trained volunteers lead fun brain exercises for people with mild to moderate dementia. The goal is to see if this helps their thinking skills and quality of life more than usual care. 520 people will take part in Hong Kon…

This early-stage study tests whether a program using an AI robot can help people with mild-to-moderate dementia and their caregivers become more physically active. About 60 pairs (dyads) will take part. The goal is to see if the program is practical and improves activity levels a…

This study tests whether a mobile app called DemensiaKITA can help family caregivers of people with dementia. About 451 caregivers in Malaysia will either use the app or continue with usual support. The goal is to see if the app improves caregivers' knowledge, attitudes, and dail…

This study tests whether walking on a treadmill while doing a thinking task (like counting or naming) improves movement and memory more than just walking alone. It involves 46 people with early-to-mid Alzheimer's who can already walk. The goal is to see if this combined training …

This study tests a computer-based program (CAST) to reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and to ease the burden on their care partners. About 388 pairs (patient and care partner) will take part. The program involves two sessi…

This study tests a personalized home activity program for people with mild-to-moderate dementia who have just left the hospital. The program is designed to reduce behavioral and psychological symptoms, like agitation or mood changes. Participants will follow a tailored activity p…

This study tests whether a low-dose, slow-release form of levetiracetam (AGB101) can reduce overactivity in a key memory region of the brain in healthy older adults. Overactivity in this area is linked to higher dementia risk. Sixty participants aged 50-80 will receive both the d…

This study is testing whether personalized music playlists can help improve behavioral and psychological symptoms in people with dementia. Researchers will create custom playlists for 1080 participants living in care homes or at home, based on their musical history. The goal is t…

This study is testing a mobile app called Care Buddy that helps family caregivers of people with dementia find community services, healthcare advice, and peer support. About 210 caregivers in Singapore will use the app to see if it improves their well-being, reduces stress, and i…

This study tests a live video program called Resilient Together for Dementia (RT-D) for couples where one partner was recently diagnosed with dementia. The goal is to see if the program is practical and helps prevent long-term emotional distress. About 50 couples will participate…

This study tests whether Jing Si Herbal Tea can improve quality of life and sleep for people with dementia and their caregivers. Over three years, 400 participants will take the tea or a placebo twice daily for six months. Researchers will measure changes in well-being and daily …

This study tests a web-based program called NiteCAPP to improve sleep in 100 rural dementia caregivers who have insomnia. Participants will use the program and report on their sleep, mood, and stress over 12 months. The goal is to see if the program helps caregivers sleep better …

This study tests whether virtual cycling—pedaling a stationary bike while watching an interactive film—can boost quality of life for older adults with cognitive impairment living in nursing homes. Researchers will compare changes in mood and behavior between a group that cycles a…

This pilot study tests whether a door-through-door rideshare service with a trained companion driver helps older adults (60+) with Alzheimer's or related dementias attend more medical appointments compared to standard curb-to-curb rideshare. About 120 participants in the San Fran…

This study tests a 6-week video program that teaches sleep-improving skills to older adults with memory loss or dementia and their care partners. Researchers want to see if the program is practical and helpful for improving sleep, mood, and daily life. About 80 pairs (person with…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—a lack of interest or motivation—is common and disabling in these conditions. The study includes 10 participa…

This study tests whether different types of gentle electrical brain stimulation, combined with computer-based thinking exercises, can improve memory and thinking in people with dementia. About 100 older adults with mild to moderate dementia will receive either real or fake stimul…

This study tests whether a sport stacking (cup stacking) program can improve health and quality of life for people with mild dementia and their family caregivers. About 144 pairs (person with dementia and their caregiver) will take part in online group sessions and home practice …

This study is testing a mobile app called CarePair that helps family caregivers of people with dementia find support services. The goal is to see if using the app for six weeks can reduce stress, depression, and feelings of being overwhelmed. About 80 caregivers will participate,…

This study tests a short online program for people who have recently become caregivers for a friend or family member with dementia. The program teaches skills to manage symptoms, find support, and handle medications. Researchers want to see if it helps caregivers feel more in con…

This study tests a remote education program called Tele-Savvy, designed specifically for Latino caregivers of people with Alzheimer's or related dementias. The program includes weekly group sessions and videos to help caregivers build skills and feel more confident. Researchers w…

This study tests a hearing care program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and distress, and also ease the burden on caregivers. 300 people a…

This study tests a device called ATNC MDD-V1 that uses gentle magnetic pulses and brain exercises to improve thinking and memory in people with mild Alzheimer's. About 180 adults aged 60 to 85 who are already on stable Alzheimer's medication will receive either the real treatment…

This study tests a new AI-powered talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild dementia or memory problems. The therapy uses a virtual coach to help people share memories and improve their mood and thinking. Researchers want to see if it can red…

This study tests a Zoom-based education and skill-training program for people aged 60+ with early-stage dementia or mild cognitive impairment who live alone. The goal is to reduce stress, improve well-being, and help plan for the future. Researchers will gather feedback from 70 p…

This study tests a 16-week partner exercise program for people with mild dementia and their family caregivers. The goal is to improve thinking, mood, and the relationship between the pair. About 236 dyads will be recruited from community centers in Hong Kong.

This study tests whether a gentle, non-invasive brain stimulation technique (called tES) can improve memory, thinking, and walking in older adults with mild cognitive impairment or mild dementia. Caregivers are trained to deliver the stimulation remotely under guidance. The goal …

This study is testing a new way to teach family members caring for someone with dementia. It compares a special learning method that uses practice quizzes and feedback to traditional reading materials. The goal is to see if this method helps caregivers remember information better…

This study is following 2950 people, including healthy individuals and those with memory or movement problems, to learn more about brain diseases like Alzheimer's and Parkinson's. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve di…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…

This study aims to create and test new tools for diagnosing cognitive issues like dementia and psychiatric disorders. Researchers will work with 300 healthy volunteers and patients to develop tests that can be done in person, over the phone, or at the bedside. The goal is to make…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…

This study explores better methods for running clinical trials in dementia and cognitive decline. Researchers will use a new measurement called 'δ' that combines thinking ability and daily function, along with blood protein levels, to see if they can predict who will respond to t…

This study looks at brain activity while people perform thinking tasks like memory and attention exercises. Researchers hope to learn how the brain works in conditions like dementia, ADD, and depression. About 30 adults with epilepsy who are already scheduled for brain monitoring…

This study looks for genetic causes of movement disorders (like tremors or stiffness) and dementia (memory loss). Researchers will collect blood or saliva from up to 12,000 people, including patients and their family members, as well as healthy volunteers. The goal is to better u…

This study tests whether music therapy can alter brain-related molecules found in saliva. Researchers will compare 60 older adults—some healthy, some with mild memory issues, and some with Alzheimer's—before and after music sessions. The goal is to find scientific proof that musi…

This study tests a special toolkit designed to help primary care doctors have better conversations about future care with people living with Alzheimer's or other dementias. About 120 patients and their doctors will take part over 18 months. The goal is to see if the toolkit leads…

This study aims to create and test a personalized program for women going through menopause who have a higher risk of dementia. The program will help them manage their fears and learn healthy coping strategies. Researchers will first talk to small groups of women to understand th…

This study will collect genetic information and health records from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will analyze this data to find better ways to diagnose and treat these conditions. Par…

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia and their caregivers learn about and reduce potentially harmful medications. A pharmacist will work with them to align medicines with their personal goals. The st…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study looks at the experiences of extended family members—like grandchildren, siblings, and nieces/nephews—who care for a loved one with dementia. Researchers will interview 240 caregivers about their daily tasks, stress, and the support they use. The goal is to find ways to…

This study follows 1,200 people from two memory clinics in Paris to see if sleep-wake cycles and other personal factors are linked to different types and stages of dementia. Researchers will track participants for up to 15 years using routine clinic visits. The goal is to find si…

This study compares two online training programs for staff who care for people with dementia in assisted living facilities. About 1,764 staff and family members will take part to see if the training improves staff knowledge, attitudes, and care practices. The goal is to find the …

This study watches sleep and body rhythms in 150 older adults (70+) before major orthopedic surgery. Researchers collect blood samples and use a wrist monitor to see if sleep problems link to postoperative delirium. No treatment is given—the goal is to find early warning signs.

This study follows 10,000 adults aged 18 and older for life to see if simple health measurements can predict how long and how well people age. Researchers will track deaths, diseases, and disabilities to find early warning signs. No treatments or drugs are tested—just observation…

This study collects blood or brain tissue from families where at least two members have Alzheimer's or dementia. The goal is to build a large DNA bank so scientists can find the genes that raise the risk of late-onset Alzheimer's. Participants do not receive treatment or test res…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other similar diseases. Researchers want to see if inflammation levels are higher in these patients compared to healthy volunteers. Participants will have MRI…

This study is building a large group of 1,000 older adults (age 60+) in Tennessee to help researchers better understand Alzheimer's disease. Participants include people with normal memory, mild memory problems, or Alzheimer's. They will have yearly check-ups, brain scans, and blo…

This study tests a program called DECLARE that helps caregivers of people with dementia who receive home health care. Caregivers answer a short questionnaire, and their responses are shared with the care team to connect them with a social worker. The goal is to see if this approa…

This study tests a communication program called COACH-Cog for older adults who have both Alzheimer's or related dementia and cancer. The goal is to help patients, their care partners, and doctors talk together more clearly about cancer treatment choices. About 300 people will tak…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to notice signs of pain and talk about it with doctors. The study …

This study aims to enroll up to 550 adults with Down syndrome, ages 25-55, into a 'trial-ready' group. Researchers will track memory, thinking, genetics, and brain changes over time to better understand Alzheimer's disease in this population. The goal is to prepare a group of vol…

This study looks at whether special eye scans can find early signs of Alzheimer's disease and other dementias. Researchers will check for changes in blood flow and protein buildup in the retinas of 20 older adults with mild dementia, compared to healthy volunteers. The goal is to…

This study looks at whether a simple tablet-based test can help primary care doctors detect cognitive impairment, including dementia, in older adults during regular visits. The test is designed to be easy to use and automatically scores results. Researchers will compare detection…

This study is looking at whether certain substances in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 adults aged 60 and older, including those with and without memory issues, to see how well these blood ma…

This study tests a new method to help primary care doctors detect early signs of dementia or memory loss in underserved communities. Over 45,000 adults aged 65 and older without prior diagnosis will participate across 24 clinics. The goal is to see if using a quick cognitive test…

This study tests whether a special way of practicing information helps dementia caregivers remember and apply what they learn about managing difficult behaviors. About 60 informal caregivers (like family members) will take part. The goal is to see if this learning method improves…

This study looks at how dementia and mild cognitive impairment (MCI) impact thinking, daily activities, and mood. Researchers will assess 151 adults aged 50-86 to better understand these conditions. The goal is to improve care by tailoring treatments to each person's needs.

This study tests whether a new wearable device that uses ultrasound and light can safely and easily monitor blood flow in the brains of people who have had a stroke. Researchers will also include healthy older adults and people with dementia, depression, or delirium to compare re…

This study is looking for signs that the immune system might be attacking the brain in people with new or worsening memory problems. Researchers will test blood from 300 adults aged 40-90 to see if certain immune markers are linked to cognitive decline. The goal is to better unde…

This study looks at how sleep and exercise habits influence the risk of Alzheimer's and dementia. Researchers will track 30 adults who have mild memory or thinking problems. Participants will wear a headband and a Fitbit to measure sleep and heart health, and provide blood and ur…

This registry collects contact and basic information from people who want to stay informed about Alzheimer's prevention research. Enrollees receive news and study opportunities by email, with no obligation to join any study. The goal is to connect volunteers with research that ma…

This study tests a tool called CGM ASSIST that uses a continuous glucose monitor and easy-to-read displays to help people with both dementia and diabetes, along with their caregivers and doctors, better understand blood sugar levels and make care decisions together. About 62 pati…

This study is following 10,000 people aged 50 and older living in Scotland over many years. Researchers are collecting information on memory, thinking, lifestyle, and health risks to learn how dementia develops. The goal is to build a detailed picture of the Scottish population t…

This study is following 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk. Researchers will collect medical records and survey data over time to identify what factors lead to brain diseases. The goal is to find ways to keep br…

This study aims to better predict how dementia will progress in individuals with mild cognitive impairment or early dementia. Researchers will collect blood samples and use computer models to track changes in thinking and memory over time. The goal is to improve prognostic confid…

This study compares a new infection management approach to usual care in nursing homes for people with dementia. The goal is to see if the new method reduces antibiotic use and unnecessary hospital visits. About 750 residents aged 60 and older with dementia will take part.

This study looks at whether being bilingual helps people with primary progressive aphasia (PPA) respond better to speech therapy. Researchers will give tailored language treatment in both languages to 60 bilingual Spanish speakers and track their progress for a year. Another 30 p…

This study follows 1000 adults with primary aldosteronism (a hormone condition that raises blood pressure) for up to 5 years to see how often thinking and memory problems develop. Participants take regular cognitive tests and medical check-ups. The goal is to understand how commo…

This study looks at how Alzheimer's patients naturally speak and compares it to fictional portrayals of dementia in novels. Researchers want to find similarities and differences in memory loss patterns. The goal is to create a tool that helps doctors diagnose dementia earlier and…

This study tests a program called PAIN-CPG-EIT, which helps nursing home staff better assess and manage pain in residents with dementia. About 300 residents from 12 nursing homes will take part. Half of the homes will get the full program with coaching and support, while the othe…

This study aims to find digital markers of brain energy changes in people with mild cognitive impairment or early Alzheimer's. Researchers will use passive home sensors to measure sleep, movement, and walking speed over 12 weeks. Participants take a daily supplement called nicoti…