Can a shot every 12 weeks stop Alzheimer's before it starts?

NCT ID NCT06647498

Recruiting now Prevention Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This study tests a drug called remternetug in people who have a strong genetic risk for Alzheimer's but do not yet have symptoms. The goal is to see if the drug can prevent or slow the buildup of harmful proteins in the brain. About 280 participants will receive either the drug or a placebo every 12 weeks for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: remternetug (a drug given as a shot every 12 weeks)
What this could lead to: If it works, this could point toward a way to prevent or delay Alzheimer's disease in people who are genetically destined to get it.
What could go wrong: This is an early-to-mid-stage trial with only 280 participants. The drug may not slow the disease, and side effects from anti-amyloid treatments can include brain swelling or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

dementia familial Alzheimer disease Alzheimer disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMERS DISEASE ALZHEIMERS DISEASE, FAMILIAL DEMENTIA

Contacts and locations

Locations

Advocate Lutheran General Hospital
RECRUITING

Park Ridge, Illinois, 60068, United States
Alzheimer's Research Australia
RECRUITING

Melbourne, Victoria, 3010, Australia
Asan Medical Center
NOT_YET_RECRUITING

Seoul, South Korea
Azienda Ospedaliera Universitaria Careggi
NOT_YET_RECRUITING

Florence, 50134, Italy
Brain Research Center
NOT_YET_RECRUITING

Amsterdam, 1081 GM, Netherlands
Butler Hospital
RECRUITING

Providence, Rhode Island, 02096, United States
CHU de Quebec - Hôpital de l' Enfant Jésus
RECRUITING

Québec, G1J 1Z4, Canada
CHU de Rouen - Hôpital Charles Nicolle
NOT_YET_RECRUITING

Rouen, Seine Maritime, 76031, France
CHU de Toulouse - Hôpital Purpan
NOT_YET_RECRUITING

Toulouse, Haute Garonne, 31059, France
Emory University
RECRUITING

Atlanta, Georgia, 30329, United States
Groupe Hospitalier Pitie-Salpetriere
NOT_YET_RECRUITING

Paris, Paris, 69677, France
Grupo de Neurociencias Sede de la Universidad de Antioquia
RECRUITING

Medellín, Colombia
Hopital Neurologique Pierre Wertheimer
NOT_YET_RECRUITING

Bron, Rhone, 69677, France
Hopital Roger Salengro - CHU Lille
NOT_YET_RECRUITING

Lille, Nord, 59037, France
Hospital Clínic I Provincial de Barcelona
RECRUITING

Barcelona, 8036, Spain
IRCCS Centro San Giovanni di Dio Fatebenefratelli
NOT_YET_RECRUITING

Brescia, 25125, Italy
Indiana University School of Medicine
RECRUITING

Indianapolis, Indiana, 46202, United States
Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
NOT_YET_RECRUITING

Mexico City, Mexico City, 14269, Mexico
Instituto de Investigaciones Neurologicas Raul Carrea, FLENI
RECRUITING

Ciudad Autonoma de Buenos Aire, C1428AQK, Argentina
Kerwin Research and Memory Center
RECRUITING

Dallas, Texas, 75231, United States
LMU-Campus Grosshadern
NOT_YET_RECRUITING

Munich, Bavaria, 81377, Germany
McGill Center for Studies in Aging
RECRUITING

Verdun, Quebec, H4H 1R3, Canada
Neuroscience Research Australia
RECRUITING

Randwick, New South Wales, 2031, Australia
New York University Medical Center
RECRUITING

New York, New York, 10016, United States
New Zealand Brain Research Institute
NOT_YET_RECRUITING

Christchurch, 8011, New Zealand
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
The National Hospital for Neurology and Neurosurgery
RECRUITING

London, Greater London, WC1B 3BG, United Kingdom
UBC Hospital
RECRUITING

Vancouver, British Columbia, V6T 2B5, Canada
Universitaetsklinikum Tubingen
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
University of Alabama in Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California San Diego Medical Center
RECRUITING

La Jolla, California, 92037, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Puerto Rico, School of Medicine
RECRUITING

San Juan, 00936, Puerto Rico
University of Southern Califonria
NOT_YET_RECRUITING

Los Angeles, California, 90089, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.