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Could tiny doses of radiation slow Alzheimer's? a new trial investigates

NCT ID NCT07693140

Recruiting now Disease control Sponsor: Evan Thomas Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether very low doses of radiation delivered to the whole brain are safe and can help preserve thinking and memory in people with Alzheimer's disease or certain dementias with inflammation. Participants receive an initial course of 10 radiation sessions, followed by monthly maintenance treatments for a year. The trial aims to see if this approach can calm brain inflammation and slow cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Low-dose whole-brain radiotherapy
What this could lead to
If successful, this could offer a new way to slow memory loss and cognitive decline in Alzheimer's disease by calming brain inflammation.
What could go wrong
This is an early-phase trial with only 50 participants, so results may not apply widely. Radiation to the brain carries risks of side effects like headache or fatigue, and the treatment may not improve cognition.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia frontotemporal dementia Lewy body dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER ALZHEIMER DEMENTIA ALZHEIMER DEMENTIA (AD) ALZHEIMER'S DISEASE DEMENTIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Renaissance Institute of Precision Oncology & Radiosurgery

    RECRUITING

    Winter Park, Florida, 32789, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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