ALZHEIMER DEMENTIA (AD)

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Researchers think these drugs might slow memory decline by blocking a process linked to Alzheimer's. Abo…

This early-stage study tests a procedure called deep brain stimulation (DBS) for people with early Alzheimer's. A device sends mild electrical pulses to a brain area involved in memory. Half of the 12 participants will receive DBS, while the other half will receive standard care.…

This study tests if levetiracetam, a seizure medication, can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and poss…

This study tests a new, non-invasive treatment called transcranial pulse stimulation (TPS) for people with early Alzheimer's disease. TPS uses gentle, focused sound waves to stimulate the brain, aiming to improve memory and thinking. The study will involve 40 adults aged 60-90 an…

This early study is testing whether a natural supplement called fisetin is safe for older adults with mild Alzheimer's disease or mild cognitive impairment. Only 5 participants will take the supplement, and researchers will closely watch for any side effects. This is a very small…

This study tests whether a 24-week online positive psychology program can improve memory, thinking, and well-being in older adults with very early signs of dementia. About 128 people with subjective cognitive decline or mild cognitive impairment will join. Half take the program (…

This study tests whether combining a medication (methylphenidate) with a non-invasive brain stimulation technique (iTBS) can reduce apathy in people with Alzheimer's or mixed dementia. Apathy, or lack of motivation, is common in these conditions. The trial involves 12 participant…

This study looks at how blood flow and sugar use in the brain change in Alzheimer's disease, especially in people who also have type 2 diabetes. Researchers will use special PET scans to measure these changes in 60 older adults, including those with Alzheimer's, those with both A…

This study looks at whether a combination of genetic tests, blood markers, and data from wearable devices can predict early memory problems in people aged 55 and older who carry the ApoE4 gene, which raises Alzheimer's risk. Researchers will follow 100 participants for two years …

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 people with memory concerns or early-onset dementia, plus their family members. The goal is to better understand how genes influence the di…

This study uses a new, ultra-detailed PET scanner to see very small brain structures in healthy aging and in conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. Researchers will scan 300 volunteers and patients to find early signs of disease and create detaile…