ALZHEIMER S DISEASE

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild Alzheimer's disease or related memory problems. The drug is given via a spinal injection to see if it is safe and can lower a harmful protein called tau in the brain. The goal is to slow disease progre…

This study tests an experimental treatment called ACI-24.060 in people with early Alzheimer's disease and in adults with Down syndrome who do not have dementia. The treatment is designed to train the immune system to attack and remove harmful amyloid plaques in the brain. The mai…

This study tests if a neck surgery (connecting lymph vessels to veins) can help people with Alzheimer's disease by improving fluid drainage from the brain. About 114 adults with early-to-moderate Alzheimer's will either get surgery plus medication or medication alone. Researchers…

This early-stage study is testing whether a fecal microbiota transplant (FMT) is safe and doable for people with mild-to-moderate Alzheimer's disease. Ten participants will receive the transplant via colonoscopy, and researchers will track side effects, recruitment rates, and cha…

This early-stage study tests a new drug called RO7812653 in about 50 people with early Alzheimer's disease. The main goal is to check if the drug is safe and how the body handles it. Participants receive a single dose injected into the spine and are closely monitored for side eff…

This study looks at the long-term safety and effects of the experimental drug GSK4527226 in people with early Alzheimer's disease. All 220 participants will receive the drug and must have completed a previous related study. The main focus is on side effects, including brain swell…

This study will follow 3,000 South Korean Alzheimer's patients taking LEQEMBI for up to 6 years to monitor safety, especially brain swelling, small bleeds, and larger hemorrhages. Researchers will use real-world data from a national registry. The goal is to understand how often t…

This early-stage study tests a gene therapy that delivers a protein called BDNF directly into the brain. The goal is to see if it is safe and can slow or prevent brain cell loss in people with early Alzheimer's disease or mild cognitive impairment. The study involves 12 participa…

This study tests whether using a special device that flashes light and plays sound at 40 times per second can help people with mild Alzheimer's. Sixty participants will use the device at home for one hour each day for six months. Researchers will check brain activity, memory, and…

This study tests an experimental drug called VHB937 in people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. About 407 participants will receive either the drug or a placebo for 72 weeks, and researchers will track changes in …

This is the first study in humans to test the safety and tolerability of a new oral drug called Leucettinib-21. It will involve healthy volunteers and a small group of people with Down syndrome or Alzheimer's disease. The main goal is to see how the body handles the drug and to c…

This study is testing a new blood test that looks for tiny protein clumps linked to Alzheimer's disease. Researchers want to see if this test can accurately tell Alzheimer's apart from other types of dementia and normal aging. The study will involve 1,500 adults aged 55-75, inclu…

This study is testing whether a blood test measuring a protein called p-Tau217 can diagnose Alzheimer's disease as accurately as the current method, which requires a spinal tap. Researchers will compare results from blood and spinal fluid samples from 40 adults with suspected Alz…

This study tests a new radioactive tracer called [18F]NIDF for PET brain scans. The tracer binds to tau tangles, which are linked to Alzheimer's and other brain diseases. Researchers want to see if it is safe and can accurately show where tau builds up in the brain. About 20 heal…

This early study is testing whether a natural supplement called fisetin is safe for older adults with mild Alzheimer's disease or mild cognitive impairment. Only 5 participants will take the supplement, and researchers will closely watch for any side effects. This is a very small…

This study tests whether eating only between 10 a.m. and 8 p.m. (14 hours of nightly fasting) can reduce sleep problems, memory loss, and disease markers in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try this eating sch…

This study tests whether a combination of two drugs (KarXT and KarX-EC) can improve memory, thinking, and daily function in people with mild to moderate Alzheimer's disease. About 586 volunteers will receive either the drug combo or a placebo pill. The goal is to see if the treat…

This study tests whether giving insulin in short weekly sessions can improve how the body uses sugar and how well people with Alzheimer's think and remember. Eight adults will receive the treatment for six months and take memory tests. The goal is to see if this approach is safe …

This study tests whether a non-invasive magnetic brain stimulation technique (rTMS) can improve thinking and daily function in people with mild-to-moderate Alzheimer's disease. Researchers will enroll 66 adults and also use brain scans to understand how the treatment might help c…

This study tests a near-infrared light therapy device used at home to see if it can ease symptoms of mild to moderate Alzheimer's disease. About 320 people aged 50-85 will use either the real device or a sham device for 26 weeks. The main goal is to measure changes in memory and …

This study tests whether a new drug combination, KarXT + KarX-EC, can improve memory and thinking in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug or a placebo, and researchers will measure changes in thinking skills and dai…

This study tests whether combining a medication (methylphenidate) with a non-invasive brain stimulation technique (iTBS) can reduce apathy in people with Alzheimer's or mixed dementia. Apathy, or lack of motivation, is common in these conditions. The trial involves 12 participant…

This study tests a device called ATNC MDD-V1 that uses gentle magnetic pulses and brain exercises to improve thinking and memory in people with mild Alzheimer's. About 180 adults aged 60 to 85 who are already on stable Alzheimer's medication will receive either the real treatment…

This study tests whether shining a special light on the forehead (photobiomodulation) can improve thinking skills in people with mild memory problems or early Alzheimer's disease. About 45 adults aged 55 to 89 will receive the light treatment weekly and take cognitive tests. Rese…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…

This study looks for early warning signs of Alzheimer's disease in people who carry a gene mutation that causes it. Researchers will use blood tests, brain scans, and memory tests to find biomarkers that predict who will develop the disease. The goal is to better understand and e…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood. These particles help cells talk to each other and may influence heart and brain health. Researchers will compare blood samples from 8 healthy adults before …

This study is looking for 500 adults with Parkinson's disease, Alzheimer's disease, or type 2 diabetes to help researchers find new ways to detect and track these conditions earlier. Participants will provide blood samples, undergo brain scans, and complete thinking and movement …

This study looks at how the help provided by family and friends to people with Alzheimer's disease changes as the disease gets worse. Researchers will track 312 patients and their caregivers to understand what factors—like memory loss, behavior changes, and other health issues—af…

This study uses special brain scans (Tau PET/CT) to look at tau protein buildup in older adults with mild cognitive impairment or Alzheimer's disease. Researchers aim to understand why Alzheimer's affects people differently by linking scan patterns with memory, thinking, and othe…

This study aims to find early signs that predict memory loss and dementia in 850 older adults, including those with mild memory issues or prediabetes. Researchers will track thinking skills, brain scans, and spinal fluid markers over time. The goal is to better understand how pro…

This study follows 1,000 adults with early memory worries (but no dementia) for up to 5 years. Researchers will use blood tests and thinking assessments to see who has Alzheimer's-related changes and how learning those results affects well-being. The goal is to better understand …

This study is gathering data from 1,200 older adults (ages 60-90) who are either cognitively normal, have mild memory problems, or have mild-to-moderate Alzheimer's. Researchers will compare digital tests (like smartphone tasks) and blood markers with brain scans to see if these …

This study looks at whether simple blood tests and brain scans can help predict which older adults with memory loss or frailty will need to visit the emergency room within six months. Researchers will follow 110 people over age 64 who have trouble with daily activities. The goal …

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other similar diseases. Researchers want to see if inflammation levels are higher in these patients compared to healthy volunteers. Participants will have MRI…

This study looks at how people with Alzheimer's or frontotemporal degeneration process social information and how that relates to their behavior. Researchers will test 120 adults aged 40-85 using cognitive tasks and brain scans. The goal is to understand why some patients act dif…

This study tests a new imaging tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. About 90 volunteers aged 50 and older, including healthy individuals, will get PET and MRI scans. The goal is to understand how infla…

This study uses a special PET scan to look at brain inflammation in people with multiple sclerosis or Alzheimer's disease, compared to healthy volunteers. Researchers want to see if the pattern of inflammation differs between these diseases and relates to symptoms. Up to 250 adul…

This study looks at proteins in spinal fluid and blood to help diagnose Alzheimer's disease more accurately. Researchers will test 3,200 people, including those with Alzheimer's, mild memory problems, other dementias, and healthy volunteers. The goal is to find the best cutoff va…

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study tracks 5000 people with early Alzheimer's who are taking lecanemab in regular medical care. Researchers want to see how often brain imaging abnormalities (ARIA) occur and how doctors manage treatment when they do. The goal is to better understand the real-world safety …

This registry collects contact and basic information from people who want to stay informed about Alzheimer's prevention research. Enrollees receive news and study opportunities by email, with no obligation to join any study. The goal is to connect volunteers with research that ma…

This study looks at how Alzheimer's patients naturally speak and compares it to fictional portrayals of dementia in novels. Researchers want to find similarities and differences in memory loss patterns. The goal is to create a tool that helps doctors diagnose dementia earlier and…