New Alzheimer's drug ABBV-1758 enters early human trials

NCT ID NCT07599670

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzheimer's.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-1758
What this could lead to: If it works, this could point toward a treatment that slows Alzheimer's by reducing amyloid buildup in the brain.
What could go wrong: This is an early Phase 1/2 trial with only 210 participants, so results may not confirm effectiveness. There are also known risks like brain swelling or bleeding (ARIA).

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

Adams Clinical /ID# 277754
RECRUITING

Watertown, Massachusetts, 02472, United States
Alpine Clinical Research Center - Boulder - 47th Street /ID# 277856
RECRUITING

Boulder, Colorado, 80301, United States
Alzheimer'S Research And Treatment Center - Stuart /ID# 278206
RECRUITING

Stuart, Florida, 34997, United States
Alzheimer's Research And Treatment Center - Wellington /ID# 277749
RECRUITING

Wellington, Florida, 33414, United States
Conquest Research - Winter Park /ID# 277760
RECRUITING

Winter Park, Florida, 32789, United States
Irvine Center for Clinical Research /ID# 277752
RECRUITING

Irvine, California, 92614, United States
K2 Medical Research - Clermont /ID# 277859
RECRUITING

Clermont, Florida, 34711, United States
K2 Medical Research - The Villages /ID# 278290
RECRUITING

Lady Lake, Florida, 32159, United States
Kerwin Medical Center /ID# 277788
RECRUITING

Dallas, Texas, 75231, United States
Key Clinical Research LLC /ID# 277800
RECRUITING

Bradenton, Florida, 34207, United States
Neurology Clinic - Cordova /ID# 277790
RECRUITING

Cordova, Tennessee, 38018, United States

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