A scan that sees Alzheimer's tangles? trial puts tau tracer to the test

NCT ID NCT07752784

First seen Aug 07, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This trial tests whether a single injection of [18F]-APN-1607, a radioactive tracer that binds to tau protein, can produce PET images that match the actual tau buildup found in the brain after death. It includes healthy volunteers and people with mild cognitive impairment or Alzheimer's dementia, all aged 50 or older. The goal is to see if this imaging method can reliably detect Alzheimer's-related brain changes, which could lead to better diagnosis without needing an autopsy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
[18F]-APN-1607, a radioactive tracer for PET imaging that binds to tau protein in the brain
What this could lead to
If successful, this could validate a PET scan as a reliable way to detect Alzheimer's-related brain changes in living people, potentially improving diagnosis and monitoring.
What could go wrong
The trial is small (12 participants) and early, so results may not be conclusive. The tracer's accuracy could be limited, and it involves radiation exposure from the PET scan.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Beijing Tiantan Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100070, China

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