Can an antibody slow Alzheimer's? a new trial seeks answers

NCT ID NCT04867616

Completed Disease control Sponsor: UCB Biopharma SRL Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This phase 2 trial is testing whether an experimental antibody called bepranemab can slow the progression of Alzheimer's disease in people with early-stage symptoms. Participants receive either bepranemab or a placebo by intravenous infusion over 80 weeks. The study measures changes in memory, thinking, and daily function to see if the drug can preserve cognitive abilities.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental antibody called bepranemab
What this could lead to: If it works, this could point toward a treatment that slows memory loss and cognitive decline in early Alzheimer's disease.
What could go wrong: This is a mid-stage trial, so the drug may not prove effective or could cause side effects. Alzheimer's is complex, and many experimental treatments have failed before.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Show contact details

Locations

Ah0003 40002

Leuven, Belgium
Ah0003 40028

Berlin, Germany
Ah0003 40049

Seville, Spain
Ah0003 40105

Córdoba, Spain
Ah0003 40123

Brussels, Belgium
Ah0003 40129

Bordeaux, France
Ah0003 40159

Barcelona, Spain
Ah0003 40160

Barcelona, Spain
Ah0003 40201

Rennes, France
Ah0003 40230

Valencia, Spain
Ah0003 40267

Barcelona, Spain
Ah0003 40280

Sant Cugat del Vallès, Spain
Ah0003 40352

Pamplona, Spain
Ah0003 40371

Monza, Italy
Ah0003 40430

Munich, Germany
Ah0003 40438

Roma, Italy
Ah0003 40449

's-Hertogenbosch, Netherlands
Ah0003 40450

Amsterdam, Netherlands
Ah0003 40453

Terrassa, Spain
Ah0003 40493

Marseille, France
Ah0003 40540

Madrid, Spain
Ah0003 40575

Brussels, Belgium
Ah0003 40576

Kortrijk, Belgium
Ah0003 40578

Paris, France
Ah0003 40579

Villeurbanne, France
Ah0003 40580

Bron, France
Ah0003 40581

Toulouse, France
Ah0003 40596

Rome, Italy
Ah0003 40597

Pavia, Italy
Ah0003 40598

Rome, Italy
Ah0003 40600

Parma, Italy
Ah0003 40601

Zwolle, Netherlands
Ah0003 40602

Warsaw, Poland
Ah0003 40603

Bialystok, Poland
Ah0003 40604

Warsaw, Poland
Ah0003 40605

Katowice, Poland
Ah0003 40606

Bydgoszcz, Poland
Ah0003 40607

Warsaw, Poland
Ah0003 40608

Szczecin, Poland
Ah0003 40609

Katowice, Poland
Ah0003 40611

Wroclaw, Poland
Ah0003 40612

Barcelona, Spain
Ah0003 40613

Valencia, Spain
Ah0003 40614

Donostia / San Sebastian, Spain
Ah0003 40615

Madrid, Spain
Ah0003 40616

Zaragoza, Spain
Ah0003 40618

London, United Kingdom
Ah0003 40619

Bristol, United Kingdom
Ah0003 40621

London, United Kingdom
Ah0003 40622

Guildford, United Kingdom
Ah0003 40623

Plymouth, United Kingdom
Ah0003 40635

Nantes, France
Ah0003 40638

Ścinawa, Poland
Ah0003 40662

Birmingham, United Kingdom
Ah0003 40691

Winchester, United Kingdom
Ah0003 40774

Katowice, Poland
Ah0003 50045

Toronto, Canada
Ah0003 50291

Toronto, Canada
Ah0003 50380

Houston, Texas, 77054, United States
Ah0003 50420

Neptune City, New Jersey, 07753, United States
Ah0003 50421

Stamford, Connecticut, 06905, United States
Ah0003 50422

New Haven, Connecticut, 06510, United States
Ah0003 50423

East Providence, Rhode Island, 02914, United States
Ah0003 50424

Fairfax, Virginia, 22031, United States
Ah0003 50426

Maitland, Florida, 32751, United States
Ah0003 50427

Miami, Florida, 33125, United States
Ah0003 50428

Fresno, California, 93710, United States
Ah0003 50429

Fort Myers, Florida, 33912, United States
Ah0003 50430

Delray Beach, Florida, 33445, United States
Ah0003 50431

Fullerton, California, 92835, United States
Ah0003 50432

Norfolk, Virginia, 23507, United States
Ah0003 50434

Santa Ana, California, 92705, United States
Ah0003 50435

Boca Raton, Florida, 33487, United States
Ah0003 50436

Hialeah, Florida, 33016, United States
Ah0003 50438

Pensacola, Florida, 32502, United States
Ah0003 50440

Bellevue, Washington, 98007, United States
Ah0003 50442

Irvine, California, 92614, United States
Ah0003 50444

West Palm Beach, Florida, 33407, United States
Ah0003 50445

Braintree, Massachusetts, 02184, United States
Ah0003 50446

Westchester, Florida, 33155, United States
Ah0003 50447

San Diego, California, 92123, United States
Ah0003 50448

Saint Paul, Minnesota, 55130, United States
Ah0003 50449

Aventura, Florida, 33180, United States
Ah0003 50450

Palo Alto, California, 94303, United States
Ah0003 50451

Cincinnati, Ohio, 45219, United States
Ah0003 50452

Pasadena, California, 91106, United States
Ah0003 50453

Newton, Massachusetts, 02459, United States
Ah0003 50454

Tampa, Florida, 33613, United States
Ah0003 50455

Cordova, Tennessee, 38018, United States
Ah0003 50457

Port Orange, Florida, 32127, United States
Ah0003 50458

Long Beach, California, 90807, United States
Ah0003 50461

Ottawa, Canada
Ah0003 50462

Toronto, Canada
Ah0003 50463

Kelowna, Canada
Ah0003 50464

Ocoee, Florida, 34761, United States
Ah0003 50465

Atlantis, Florida, 33462, United States
Ah0003 50467

New Haven, Connecticut, 06510, United States
Ah0003 50476

West Palm Beach, Florida, 33409, United States
Ah0003 50478

Naples, Florida, 34105, United States
Ah0003 50479

Decatur, Georgia, 30033, United States
Ah0003 50520

Québec, Canada
Ah0003 50522

West Vancouver, Canada
Ah0003 50623

Pensacola, Florida, 32503, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.