ALZHEIMER S DISEASE

This study tests whether changing the dose schedule of donanemab can lower the risk of a brain swelling side effect called ARIA-E while still clearing amyloid plaques. About 1,175 adults with early symptomatic Alzheimer's will receive different dosing regimens over 91 weeks. The …

This study tests whether adding an experimental drug called E2814 to the approved Alzheimer's drug lecanemab can better slow the disease in people with early Alzheimer's. The trial includes 105 participants with mild cognitive impairment or mild dementia due to Alzheimer's. Resea…

This study tests the drug lecanemab in 40 people who have a genetic form of Alzheimer's disease. The goal is to see if removing amyloid plaques from the brain can delay the start of symptoms or slow the disease. Participants previously received another anti-amyloid drug and will …

This study tests a structured care plan for treating agitation and aggression in people with Alzheimer's disease. The plan combines medications and non-drug approaches based on regular assessments. Researchers will compare this approach to usual care in 187 participants living in…

This study tests an experimental daily pill (RO7269162) in 256 people who are at risk for or have very early Alzheimer's disease. Participants either have brain plaques but no symptoms, or mild cognitive impairment. The trial checks safety and whether the drug reduces amyloid pla…

This study tests an experimental drug called GSK4527226 in 367 people with early Alzheimer's (mild memory or thinking problems). Participants receive either a low dose, a high dose, or a placebo as an IV infusion. The goal is to see if the drug can slow down worsening of memory a…

This study tests a drug called remternetug against a placebo in 1400 people with early Alzheimer's who are at risk for worsening memory and thinking problems. The goal is to see if the drug can delay or prevent further decline. Participants may be in the study for up to 5 years, …

This study tests whether a drug called XBD173 can improve blood flow in the brains of people with mild-to-moderate Alzheimer's disease. About 51 participants will take the drug or a placebo twice daily for 28 days. Researchers will use MRI scans and blood tests to measure changes…

This study is testing whether consuming olive pomace oil can reduce harmful brain inflammation in people with early-stage Alzheimer's disease. Researchers will compare the effects of this oil to sunflower oil in 80 participants (40 with Alzheimer's and 40 healthy). The main goal …

This study is testing whether a blood test can identify people who have Alzheimer's-related brain changes, even before memory problems start. Researchers will enroll 2000 adults aged 50-80, some with risk factors like a family history of early dementia. The goal is to see if the …

This study tests whether a special therapy using lights, sounds, textures, and smells can help people with moderate Alzheimer's disease. 24 older adults and their caregivers will take part in 8 sessions over 4 weeks. Researchers will measure changes in thinking, behavior, and how…

This study tests a website tool called WeCareToFeedDysphagia designed to reduce stress and burden for people caring for older adults with Alzheimer's or related dementias who also have trouble swallowing. About 800 caregivers will either get access to the tool or not, and all wil…

This study tests two personalized treatments for older adults with memory problems due to Alzheimer's disease. One uses computer algorithms to create custom cognitive training exercises, and the other uses brain imaging and AI to deliver targeted electrical stimulation. About 460…

This study tests whether memory techniques (like mnemonics) can improve cognitive performance in 80 adults over 50 who have subjective cognitive decline (mild memory concerns). Participants are randomly assigned to either a memory training group (group sessions, online practice) …

This study looks at brain tissue and lab-grown nerve cells from 150 people who had schizophrenia, depression, bipolar disorder, Alzheimer's, or frontotemporal dementia. Researchers want to find out how the connections between brain cells (synapses) stop working properly in these …

This study is testing whether smartphones and wearable devices can catch early signs of Alzheimer's disease better than standard questionnaires. About 3,500 adults, including healthy volunteers and those with different stages of memory loss, will use these digital tools to track …