ALZHEIMER'S DISEASE

This study is testing whether a new type of microsurgery in the neck can help slow down Alzheimer's disease. The surgery aims to improve the brain's natural waste drainage system, which is thought to be faulty in Alzheimer's. Researchers will compare the surgery plus standard med…

This study continues testing an experimental Alzheimer's drug called GSK4527226 (AL101) to see how safe and effective it is over two years. It includes 220 people with early Alzheimer's disease who already participated in a previous trial. All participants receive the same drug w…

This study is testing whether an investigational drug called VHB937 can help slow the progression of early Alzheimer's disease. About 407 participants with mild memory problems or early Alzheimer's will receive either VHB937 or a placebo for 72 weeks, followed by an extension per…

This study is testing whether a two-drug combination called KarXT + KarX-EC can help improve thinking and memory problems in people with mild to moderate Alzheimer's disease. Researchers will compare the drug combination against a placebo in 586 participants over several months t…

This study is testing whether a special light treatment, applied to the forehead, can help people with early memory loss due to Alzheimer's disease. Researchers want to see if the light can improve thinking skills and reduce signs of brain inflammation. Participants will receive …

This study is monitoring the safety of lecanemab, a drug for early Alzheimer's disease, in real-world medical practice. It will follow 5,000 patients to track specific brain imaging side effects, including swelling and small bleeds, known as ARIA. The main goal is to see how ofte…

This study is testing an investigational vaccine called ACI-24.060 to see if it is safe and can help the body's immune system fight the harmful amyloid proteins linked to Alzheimer's disease. It is enrolling 176 adults who either have very early-stage Alzheimer's (prodromal) or a…

This study is testing whether restricting eating to a 10-hour window each day (fasting for 14 hours overnight) can help slow cognitive decline in people with mild cognitive impairment or early Alzheimer's disease. Researchers will enroll 60 older adults to follow this eating patt…

This is the first human study of an experimental drug called RO7812653 for early Alzheimer's disease. The main goal is to check if the drug is safe and well-tolerated when given as a single injection into the spinal fluid. The study will enroll about 50 participants with early me…

This large, late-stage study is testing whether a device that shines near-infrared light on the head can help slow the progression of Alzheimer's disease. About 320 people with mild to moderate Alzheimer's will use the device or a look-alike 'sham' device at home for 26 weeks. Re…

This study is testing a device that combines gentle magnetic brain stimulation with memory and thinking exercises. It aims to see if this non-invasive treatment can help slow or improve thinking problems in people with mild Alzheimer's disease. About 158 participants will receive…

This study aims to find out if a new drug combination called KarXT + KarX-EC can help control the memory and thinking problems caused by mild to moderate Alzheimer's disease. It will involve about 586 people who have been diagnosed with Alzheimer's and will compare the effects of…

This study is testing whether a non-invasive magnetic brain stimulation treatment is safe and effective for people with mild to moderate Alzheimer's disease. Researchers will measure changes in memory, thinking, and behavior in 66 participants. They will also use brain scans to e…

This is a first-in-human safety study testing a new gene therapy approach for early Alzheimer's disease and mild cognitive impairment. Researchers will use a harmless virus to deliver a protective protein called BDNF directly into the brain of 12 participants. The goal is to see …

This study is testing whether giving insulin in short weekly sessions can improve how the body uses sugar and help with thinking and memory problems in people with Alzheimer's disease. Eight adults with Alzheimer's will receive the insulin treatment once a week for six months whi…

This is a first-in-human study to check if a new drug called ALN-5288 is safe for people with Alzheimer's disease. The drug is injected into the spinal fluid. Researchers will enroll 50 adults with mild to moderate Alzheimer's to monitor for side effects and see how the drug beha…

This is the first study in people to test the safety of an experimental oral drug called Leucettinib-21. It will first be given to healthy volunteers to check for side effects and how the body processes it. Later, a single dose will be given to a small group of men with Down synd…

This study aims to find the best measurement levels for proteins in blood and spinal fluid to accurately diagnose Alzheimer's disease. It will involve 3,200 people, including those with Alzheimer's, other memory problems, and healthy individuals. Researchers will compare test res…

This study is testing whether a simple, non-invasive eye-tracking test using a VR headset can help detect early signs of cognitive decline. It will compare the eye responses of 140 adults, including people with Alzheimer's disease, mild memory problems, depression-related impairm…

This study is testing a new blood test designed to improve the diagnosis of Alzheimer's disease. Researchers will check if the test can accurately tell Alzheimer's apart from normal aging and other types of dementia by looking for tiny, harmful protein clumps in the blood. They w…

This study is testing a new blood marker called p-Tau217 to see if it can accurately diagnose Alzheimer's disease. Researchers will compare results from this blood test to the current standard method, which requires a spinal tap to collect fluid. The goal is to find a simpler, le…

This study is testing a new type of brain scan designed to better see and measure a harmful protein called tau, which builds up in diseases like Alzheimer's. Researchers will give a small, safe amount of a radioactive tracer to about 20 participants, including healthy people and …

This study is testing whether a two-part treatment can help reduce apathy, a common loss of motivation, in people with Alzheimer's disease. Researchers are combining a stimulant medication (methylphenidate) with a gentle, non-invasive brain stimulation technique. The goal is to s…

This study aims to better understand brain inflammation in neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will use PET scans to measure specific inflammation markers in the brains of 184 participants, including both patients and healthy volunteers.…

This study aims to understand how drinking a single glass of red or white wine might affect tiny particles in the blood called extracellular vesicles, which carry signals between cells. Researchers will enroll 8 healthy adults to drink wine and have their blood tested before and …

This study aims to find new, less invasive ways to detect and monitor Parkinson's and Alzheimer's disease earlier. Researchers will collect and analyze blood samples, genetic data, and brain scans from 500 people with these conditions, some of whom also have type 2 diabetes. The …

This study aims to measure the amount and cost of unpaid care provided by family members to people with Alzheimer's disease. Researchers will follow 312 patients and their caregivers to understand how care needs change as the disease progresses. The goal is to gather data to help…

This long-term study aims to identify biological markers that can predict the future development of Alzheimer's disease in people who carry a specific genetic mutation for it. It observes 700 adult children of parents with inherited Alzheimer's, tracking changes in their brain sc…

This study aims to better understand early memory concerns by following 1,000 adults in Lombardy, Italy, for seven years. Researchers will analyze blood tests for Alzheimer's-related proteins and track how people feel after learning their results. The goal is to learn how early w…

This study aims to understand dementia better by comparing how it's described in novels with the real-life stories of people who have it. Researchers will analyze language from 40 participants, including people with early Alzheimer's and healthy individuals, alongside famous book…

This study aims to create a large database to understand how simple blood tests and digital measurements relate to the buildup of harmful proteins in the brain, as seen on specialized scans. It will enroll 1,200 older adults who are cognitively normal, have mild memory issues, or…

This project is creating a large registry of people interested in Alzheimer's prevention research. The goal is to connect willing individuals with upcoming studies in their area, which could range from surveys and healthy lifestyle programs to memory tests and new drug trials. By…

This study aims to understand brain inflammation in people with Multiple Sclerosis (MS) and Alzheimer's Disease by using special PET scans. Researchers will compare brain images from 250 people, including those with active MS, progressive MS, mild Alzheimer's, and healthy volunte…

This study aims to understand if a specific enzyme linked to brain inflammation is higher in people with Alzheimer's disease or mild cognitive impairment. Researchers will use special brain imaging scans (PET and MRI) on 90 participants aged 50 and older, including those with the…

This study aims to see if a simple blood test and brain scan results can predict which frail, elderly patients who need help with daily activities will visit the emergency room within six months. Researchers will measure a protein linked to Alzheimer's disease in the blood and as…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This study uses special brain scans to measure tau protein buildup in people with mild memory problems or Alzheimer's disease. Researchers want to understand how tau relates to other brain changes and memory test scores. The study involves 100 participants who will get one brain …