Brain scans may unlock secrets of Alzheimer's differences

NCT ID NCT05658913

Recruiting now Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study uses a special PET scan with a radioactive tracer called AV-1451 to look at tau protein buildup in the brains of 100 older adults with mild cognitive impairment or Alzheimer's disease. The goal is to see how tau patterns relate to other brain changes and thinking abilities. No treatment is given—this is purely to gather knowledge about why Alzheimer's varies so much from person to person.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AV-1451 (a radioactive tracer for PET scans)
What this could lead to: If successful, this could help explain why Alzheimer's affects people differently, potentially guiding future personalized treatments.
What could go wrong: This is an observational imaging study, not a treatment trial. It will not directly improve health, and results may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114-2696, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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