Brain scans may unlock secrets of Alzheimer's differences
NCT ID NCT05658913
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study uses a special PET scan with a radioactive tracer called AV-1451 to look at tau protein buildup in the brains of 100 older adults with mild cognitive impairment or Alzheimer's disease. The goal is to see how tau patterns relate to other brain changes and thinking abilities. No treatment is given—this is purely to gather knowledge about why Alzheimer's varies so much from person to person.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AV-1451 (a radioactive tracer for PET scans)
What this could lead to
If successful, this could help explain why Alzheimer's affects people differently, potentially guiding future personalized treatments.
What could go wrong
This is an observational imaging study, not a treatment trial. It will not directly improve health, and results may not lead to immediate clinical changes.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ALZHEIMER S DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114-2696, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact