New Alzheimer's drug enters early human testing

NCT ID NCT07214727

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and how the drug moves through the body.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Clinical Trial Site

    RECRUITING

    Montreal, H3G 1H9, Canada

  • Clinical Trial Site

    RECRUITING

    Ottawa, K1Z 1G3, Canada

  • Clinical Trial Site

    RECRUITING

    Toronto, M3B 2S7, Canada

  • Clinical Trial Site

    NOT_YET_RECRUITING

    Toronto, M5T 2S8, Canada

  • Clinical Trial Site

    NOT_YET_RECRUITING

    's-Hertogenbosch, 5223, Netherlands

  • Clinical Trial Site

    NOT_YET_RECRUITING

    Amsterdam, 1081 GN, Netherlands

  • Clinical Trial Site

    NOT_YET_RECRUITING

    Barcelona, 08036, Spain

  • Clinical Trial Site

    RECRUITING

    Madrid, 28040, Spain

  • Clinical Trial Site

    NOT_YET_RECRUITING

    Sant Cugat del Vallès, 08190, Spain

  • Clinical Trial Site

    RECRUITING

    Glasgow, G51 4TF, United Kingdom

  • Clinical Trial Site

    RECRUITING

    London, WC1N 3BG, United Kingdom

  • Clinical Trial Site

    NOT_YET_RECRUITING

    Sheffield, S10 2JF, United Kingdom

  • Clinical Trial Site

    RECRUITING

    Southampton, SO16 6YD, United Kingdom